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公开(公告)号：EP1501533A2
公开(公告)日：2005-02-02
申请号：EP03728495.7
申请日：2003-04-22
发明人： MOCHLY-ROSEN, Daria , SWEITZER, Sarah, M. , KENDIG, Joan, J. , YEOMANS, D.C.,c/oStanford University Medical Cntr
IPC分类号： A61K38/00
CPC分类号： C12N9/1205 , A61K38/45 , C07K7/06 , C07K7/08
摘要： Peptide sequences derived from the V5 domain of isozymes of protein kinase C for use in pain management are described. Also described are compositions comprising the peptides for treating pain and/or inducing analgesia. Methods of pain treatment and methods of identifying compounds that mimic the activity of the peptides are also described.
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公开(公告)号：EP1461084A2
公开(公告)日：2004-09-29
申请号：EP02794232.5
申请日：2002-12-11
发明人： ROTHBARD, Jonathan, B. , WENDER, Paul, A. , PATTABIRAMAN, Kanaka , PELKEY, Erin, T. , JESSOP, Theodore, C.
IPC分类号： A61K47/48
CPC分类号： A61K47/54
摘要： Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either contiguous or spaced along a backbone, but are sufficiently removed from the backbone via tethers, to allow their interaction with a cell or tissue surface, leading to uptake of the therapeutic agent.
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3.发明公开A HELPER DEPENDENT ADENOVIRAL VECTOR SYSTEM AND METHODS FOR USING THE SAME 审中-公开辅助依赖型腺病毒载体系统和方法供其使用
公开(公告)号：EP1379281A2
公开(公告)日：2004-01-14
申请号：EP02731155.4
申请日：2002-03-25
发明人： EHRHARDT, Anja , KAY, Mark
IPC分类号： A61K48/00 , C12N15/63 , C12N15/64 , C12N15/861 , C12N5/10
CPC分类号： C12N15/86 , A61K39/00 , C12N15/90 , C12N2710/10343 , C12N2800/108 , C12N2800/30 , C12N2800/80 , C12N2800/90 , C12N2830/002 , C12N2830/008 , C12N2830/38 , C12N2830/46
摘要： A helper dependent adenoviral vector system is provided. The subject helper dependent adenoviral vector system is made up of: (1) a 'gutless' adenoviral vector that includes cis-acting human stuffer DNA that provides for in vivo long term, high level expression of a coding sequence present on the vector; (2) an adenoviral helper vector that is characterized by having an adenoviral genome region flanked by recombinase recognition sites, where the helper vectors further include a non-mammalian endonuclease recognition site positioned outside of the adenoviral genome region; and (3) a mammalian cell that expresses the corresponding recombinase and endonuclease, as well as the adenoviral preterminal and polymerase proteins (See Figure 3). Also provided are methods of using the subject systems to produce virions having the subject helper dependent adenoviral vectors encapsulated in an adenoviral capsid. In addition, kits for use in practicing the subject methods are provided.
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4.发明公开(PSI)(EPSILON)RACK PEPTIDE COMPOSITION AND METHOD FOR PROTECTION AGAINST TISSUE DAMAGE DUE TO ISCHEMIA 审中-公开（PSI）（ε）RACK肽组合物和方法保护，禁止组织损伤缺血
公开(公告)号：EP1359883A2
公开(公告)日：2003-11-12
申请号：EP01273811.8
申请日：2001-11-09
发明人： MOCHLY-ROSEN, Daria
IPC分类号： A61K7/00 , A01N37/18 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： A61K38/177 , A61K47/64 , A61K47/645
摘要： A method of reducing damage to cells and tissue caused by an ischemic or hypoxic event is disclosed. The method includes administering to the cell or tissue, either in vivo or ex vivo , psi epsilon RACK peptide. The peptide can be administered before, during or after the ischemic or hypoxic event.
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公开(公告)号：EP1261487A2
公开(公告)日：2002-12-04
申请号：EP01914479.9
申请日：2001-02-23
IPC分类号： B41J2/045
CPC分类号： B41J2/04 , B41J2202/15
摘要： A droplet ejector (11) including a cylindrical reservoir (20) closed at one end with an elastic membrane (14) including at least one aperture (22). A bulk actuator (20) at the other end for actuating the fluid for ejection through the aperture (22). Also disclosed is a micromachined two-dimensional array droplet ejector (11). The ejector (11) includes a two-dimensional array of elastic membranes (14) having orifices (22) closing the ends of cylindrical fluid reservoirs (20). The fluid in the ejectors (11) is bulk actuated to set up pressure waves (28) in the fluid which cause fluid to form a meniscus at each orifice (22). Selective actuation of the membranes (14) ejects droplets. In an alternative mode of operation, the bulk pressure wave has sufficient amplitude to eject droplets while the individual membranes (14) are actuated to selectively prevent ejection of droplets.
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公开(公告)号：EP1261366A1
公开(公告)日：2002-12-04
申请号：EP01914490.6
申请日：2001-02-22
CPC分类号： A61K39/39 , A61K38/18 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2300/00
摘要： The immunogenicity of an antigen is enhanced by increasing the specific antigen presenting function of dendritic cell (DC) in a mammalian host. The host is treated with a DC mobilization agent to increase the number of circulating DC precursors. The host is then given a local, injection of antigen in combination with a DC activating agent. The activation step promotes recruitment and maturation of the DC, along with antigen-specific activation and migration from the tissues to lymphoid organs. These DC then effectively interact with, and present processed antigen to, T cells that are then able to respond to the antigen. In one aspect of the invention, the antigen is a tumor antigen, and is used to enhance the host immune response to tumor cells present in the body.
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7.发明公开BIFUNCTIONAL MOLECULES HAVING MODULATED PHARMACOKINETIC PROPERTIES AND THERAPIES BASED THEREON 审中-公开用调制的药代动力学特性和基于事实的治疗双功能分子
公开(公告)号：EP1229793A1
公开(公告)日：2002-08-14
申请号：EP00983722.0
申请日：2000-11-17
IPC分类号： A01N61/00 , A61K38/00 , A61K38/43 , C12N11/00 , C12N11/02 , C07K1/00 , C07K17/00 , C07K17/02 , C07K17/06
摘要： Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules are further characterized in that they exhibit at least one modulated pharmacokinetic property upon administration to a host as compared to a free drug control. The subject bifunctional molecules find use in a variety of therapeutic applications.
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公开(公告)号：EP1151505A1
公开(公告)日：2001-11-07
申请号：EP00909886.4
申请日：2000-01-05
IPC分类号： H01S3/067
CPC分类号： H04B10/296 , H01S3/094042 , H01S3/1302 , H01S3/131 , H01S3/1608 , H01S3/1691 , H01S2301/04
摘要： An optical amplifier has a gain profile which is substantially flat and independent, over a wide range, of the pump power, power of the input signals, and the number of input signals. The amplifier utilizes an optical resonator having a gain medium whose gain broadening behaves inhomogeneously by pumping the gain medium at at least one wavelength in at least one absorption tail of the gain medium. The resonator is a ring resonator that preferably includes an erbium-doped fiber. Codopants may be added to the fiber to enhance the inhomogeneous broadening effect. A method of gain flattening introduces a pump signal into a gain medium. The pump signal has a wavelength in the tail of the absorption profile of the gain medium. A plurality of optical signals at different wavelengths are introduced into the gain medium. Stimulated emission within the gain medium clamps the gain of the gain medium.
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9.发明公开
公开(公告)号：EP1131838A1
公开(公告)日：2001-09-12
申请号：EP99972363.8
申请日：1999-11-04
CPC分类号： H01J9/025 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/162 , C01B2202/06 , C01B2202/08 , H01J1/304 , H01J2201/30469 , Y10S977/939
摘要： A field emission device (20) having bundles (28) of aligned parallel carbon nanotubes on a substrate (22). The carbon nanotubes (28) are oriented perpendicular to the substrate (22). The carbon nanotube bundles (28) may be up to 300 microns tall, for example. The bundles (28) of carbon nanotubes extend only from regions of the substrate (22) patterned with a catalyst material (26). Preferably, the catalyst material (26) is iron oxide. The substrate (22) is preferably porous silicon, as this produces the highest quality, most well-aligned nanotubes. Smooth, nonporous silicon or quartz can also be used as the substrate. The method of the invention starts with forming a porous layer on a silicon substrate by electrochemical etching. Then, a thin layer of iron is deposited on the porous layer in patterned regions. The iron is then oxidized into iron oxide, and then the substrate is exposed to ethylene gas at elevated temperature. The iron oxide catalyzes the formation of bundles of temperature. The iron oxide catalyses the formation of bundles of aligned parallel carbon nanotubes which grow perpendicular to the substrate surface. The height of the nanotube bundles above the substrate is determined by the duration of the catalysis step. The nanotube bundles only grow from the patterned regions.
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公开(公告)号：EP1125346A2
公开(公告)日：2001-08-22
申请号：EP99971212.8
申请日：1999-10-29
IPC分类号： H01S3/067
CPC分类号： H01S3/06795 , H01S3/094042
摘要： The instability of the mean wavelength of a superfluorescent fiber source (SFS) is reduced by randomizing the polarization of light from a pump source or by using polarization maintaining components. In one embodiment, the polarization of a pump source is made more random, leading to greater stability of the mean wavelength of the SFS, with an output mean wavelength that is stable to better than 3 ppm for full rotation of the pump polarization state. In another embodiment, the polarization of optical radiation throughout the device is kept substantially constant by using polarization maintaining fiber and components, thereby leading to enhanced mean wavelength stability of the SFS.
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