公开(公告)号：EP4397755A2

公开(公告)日：2024-07-10

申请号：EP24153256.3

申请日：2012-12-14

申请人： The Board of Trustees of the University of Arkansas ,  The Kitasato Institute ,  Montefiore Medical Center ,  National University Corporation Kagawa University

发明人： SAKON, Joshua ,  PHILOMINATHAN SAGAYA, Theresa, Leena ,  KATIKANENI, Ranjitha ,  MATSUSHITA, Osama ,  PONNAPAKKAM, Tulasi ,  KOIDE, Takaki ,  GENSURE, Robert, C. ,  NISHI, Nozomu

IPC分类号： C12N9/52

CPC分类号： A61K38/29 ,  A61K8/4913 ,  A61K8/65 ,  A61Q7/00 ,  A61K47/64 ,  A61K38/179 ,  A61K38/18 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/193 ,  A61K38/30 ,  A61K38/00 ,  A61K38/1808 ,  A61K38/1875 ,  A61K38/27 ,  C12N9/52 ,  C12Y304/24003 ,  A61P17/00 ,  A61P17/14 ,  A61P19/00 ,  A61P19/04 ,  A61P19/10 ,  A61P5/18 ,  A61P5/20 ,  Y02A50/30

摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

公开(公告)号：EP3318664B1

公开(公告)日：2024-06-12

申请号：EP15897201.8

申请日：2015-10-06

IPC分类号： D02G3/36 ,  G01N27/02 ,  A61M1/36

CPC分类号： D02G3/36 ,  A61M2205/1520130101 ,  A61M2205/331720130101 ,  D10B2509/0220130101 ,  A61M1/3656 ,  G01N27/02 ,  D02G3/441 ,  G01N33/48785

公开(公告)号：EP3167919B1

公开(公告)日：2021-03-31

申请号：EP14897191.4

申请日：2014-07-08

发明人： MATSUDA, Kenichi ,  KOKUBO, Kenichi ,  KOBAYASHI, Hirosuke ,  SUNOHARA, Takashi ,  NOTAZAWA, Shunsuke ,  FUKUSHIMA, Hiroshi

IPC分类号： A61M1/16 ,  A61M1/18 ,  B01D63/02 ,  B01D69/02

公开(公告)号：EP3597647A1

公开(公告)日：2020-01-22

申请号：EP18768432.9

申请日：2018-03-16

申请人： The Kitasato Institute ,  BF Agro Co., Ltd.

发明人： OMURA, Satoshi ,  TAKAHASHI, Yoko ,  NAKASHIMA, Takuji ,  MATSUO, Hirotaka ,  NONAKA, Kenichi ,  SAKATO, Hisako

IPC分类号： C07D407/04 ,  A61K31/352 ,  A61P1/02 ,  A61P1/04 ,  A61P7/00 ,  A61P9/00 ,  A61P11/00 ,  A61P11/04 ,  A61P11/08 ,  A61P13/02 ,  A61P13/08 ,  A61P13/10 ,  A61P13/12 ,  A61P15/08 ,  A61P17/00 ,  A61P17/02 ,  A61P17/18 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P39/06

摘要： It is known that foods containing a carbohydrate, e.g., starch, in a large amount produce acrylamide upon heating at high temperatures. Some documents state that acrylamide is formed by the Maillard reaction of an amino acid, e.g., asparagine, with a reducing sugar. The purpose of the present invention is to provide a novel compound which is effective in inhibiting such foods from yielding acrylamide when treated at a high temperature. Specifically, the present invention provides a compound represented by General Formula (I).

公开(公告)号：EP3533795A1

公开(公告)日：2019-09-04

申请号：EP17865551.0

申请日：2017-10-25

申请人： Carna Biosciences, Inc. ,  The Kitasato Institute

发明人： SAWA, Masaaki ,  ASAMITSU, Yuko ,  UNO, Yuko ,  OMURA, Satoshi ,  OTOGURO, Kazuhiko ,  IWATSUKI, Masato ,  ISHIYAMA, Aki ,  HOKARI, Rei

IPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/5377 ,  A61P33/06 ,  C07D491/056 ,  C07D491/107

摘要： The present invention provides a novel 2,4,6-substituted pyrimidine derivative, which is a compound represented by formula (I) (in the formula, ring A is a 6-membered heteroaryl group having at least one N atom optionally substituted with R1, R2, and R3; Z is an optionally substituted alkoxy group, an optionally substituted amino group, an optionally substituted heterocycloalkyl group, or an optionally substituted heteroaryl group; and R1, R2, and R3 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted alkoxy group, an optionally substituted cycloalkyloxy group, an optionally substituted heterocycloalkyloxy group, an optionally substituted phenoxy group, an optionally substituted amino group, a nitro group, and a hydroxy group) or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3530674A1

公开(公告)日：2019-08-28

申请号：EP17861867.4

申请日：2017-10-19

申请人： Denka Company Limited ,  Tokyo Institute of Technology ,  The Kitasato Institute ,  JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES

发明人： UENO Takafumi ,  YOSHIKAWA Kengo ,  MANO Megumi ,  KATAYAMA, Kazuhiko ,  MIKI, Motohiro ,  TODAKA, Reiko ,  TAKAHASHI, Yoshimasa ,  ONODERA, Taishi

IPC分类号： C07K19/00 ,  A61K39/125 ,  A61P31/12 ,  C07K7/08 ,  C07K14/00 ,  C07K14/005 ,  C07K14/08 ,  C12N15/09 ,  C12P21/02

摘要： The present invention addresses the issue of providing: a norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration, that is capable of easily immunizing target cells; a molecular needle aggregate being an effective component thereof; and a production method therefor. A norovirus component vaccine is provided that has as an effective component thereof an aggregate including a hexamer having two molecules of a trimer of a molecular needle indicated by formula (1) bound thereto. W-L 1 -X n -Y (1) [In the formula, W indicates a P domain amino acid sequence in a norovirus capsid protein that is the immunogen, L 1 indicates a first linker sequence having 0-100 amino acids, X indicates an amino acid sequence of SEQ ID No. 1, Y indicates an amino acid sequence in a cell introduction area, and n indicates an integer of 1-3.]

公开(公告)号：EP3480195A1

公开(公告)日：2019-05-08

申请号：EP17200415.2

申请日：2017-11-07

申请人： Bayer Animal Health GmbH ,  The Kitasato Institute

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07D413/14 ,  A01N43/72 ,  A61K38/15 ,  A61K45/06 ,  C07C269/06 ,  C07C271/22 ,  C07B51/00 ,  C07C231/12 ,  C07D273/00 ,  C07D273/08 ,  C07K11/02

摘要： The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, involving specific carboxylic acid group protecting tags:

TAG is preferably:

wherein m is ≥ 15 to ≤ 25, p is ≥ 8 to ≤ 18 and q is ≥ 15 to ≤ 25.

公开(公告)号：EP2111756B1

公开(公告)日：2017-08-02

申请号：EP09164961.6

申请日：2006-05-31

申请人： Meiji Seika Pharma Co., Ltd. ,  The Kitasato Institute

发明人： Goto, Kimihiko ,  Horikoshi, Ryo ,  Tsuchida, Mariko ,  Oyama, Kazuhiko ,  Omura, Satoshi ,  Tomoda, Hiroshi ,  Sunazuka, Toshiaki

IPC分类号： A01P7/04 ,  A01N43/90

CPC分类号： C07D493/04 ,  A01N43/90

摘要： Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I)or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carreir:

摘要翻译： 本发明公开了用作有害生物防除剂的组合物，其包含作为活性成分的由式（I）表示的化合物或其农业和园艺上可接受的盐以及农业和园艺上可接受的卡雷尔：

公开(公告)号：EP2752416B1

公开(公告)日：2016-03-09

申请号：EP12828060.9

申请日：2012-08-31

申请人： The Kitasato Institute

发明人： OMURA, Satoshi ,  TAKAHASHI, Yoko ,  NAKASHIMA, Takuji ,  OTOGURO, Kazuhiko ,  SHIOMI, Kazuro ,  IWATSUKI, Masato ,  MATSUMOTO, Atsuko

IPC分类号： C07D493/18 ,  A61K31/366 ,  A61P33/00 ,  C12N1/20 ,  C12P1/06 ,  C12P17/18 ,  C07D493/16 ,  C12R1/01

CPC分类号： C07D493/16 ,  C07D493/18 ,  C12P17/181 ,  C12R1/01

公开(公告)号：EP2019147B1

公开(公告)日：2011-05-04

申请号：EP06732665.2

申请日：2006-05-16

申请人： THE KITASATO INSTITUTE

发明人： TOMODA, Hiroshi ,  KIM, Yong-pil ,  HANAKI, Hideaki ,  MATSUMOTO, Atsuko ,  TAKAHASHI, Yoko ,  OMURA, Satoshi

IPC分类号： C12P19/26 ,  C07H11/04 ,  A61K31/7024 ,  A61P31/04

CPC分类号： C07H11/04 ,  C07C323/59 ,  C12P13/02 ,  C12P19/26 ,  C12P19/44 ,  C12R1/465

摘要： K04-0144 substances A, B and C which can be produced by culturing a microorganism exemplified by Streptomyces sp. strain K04-0144 (which is capable of producing K04-0144 substances) in a culture medium and then collecting the substances from the culture medium. The substances have a potent antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and are therefore useful as therapeutic agents for MRSA infection and infectious diseases caused by multidrug-resistant bacteria including β-lactam antibiotic-resistant bacteria. A novel K04-0144 substance D which is also collected from the culture medium can enhance the effect of a β-lactam antibiotic (which has been used as an antibacterial agent) by using it in combination with the β-lactam antibiotic, and is therefore useful as a therapeutic agent for methicillin-resistant Staphylococcus aureus (MRSA) infection and infectious diseases caused by multidrug-resistant bacteria including β-lactam antibiotic-resistant bacteria.