公开(公告)号：EP2557155A1

公开(公告)日：2013-02-13

申请号：EP11765233.9

申请日：2011-04-06

申请人： IHI Corporation ,  Ishikawa, Yoshihiro

发明人： ISHIKAWA, Yoshihiro ,  EGUCHI, Haruki ,  SATO, Hiroshi

IPC分类号： C12N9/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/43 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K47/48 ,  A61P35/00 ,  C07F15/02

CPC分类号： A61K47/48076 ,  A61K9/0009 ,  A61K41/00 ,  A61K47/547

摘要： A metal-salen complex derivative with an excellent yield and stability is provided and a method for producing such a metal-salen complex derivative is provided. The present invention provides: metal-salen complex derivative obtained by allowing a target component composed of at least one of an enzyme, an antibody, an antigen, a peptide, an amino acid, an oligonucleotide, a protein, a nucleic acid, and a medical molecule to bind to a metal-salen complex via an amide bond or a disulfide bond; a method for producing such a metal-salen complex derivative.

摘要翻译： 提供了具有优异的产率和稳定性的金属 - salen复合衍生物，并提供了这种金属 - salen络合物衍生物的制备方法。 本发明提供：通过使由下列组成的目标成分得到的金属 - salen复合体衍生物：由酶，抗体，抗原，肽，氨基酸，寡核苷酸，蛋白质，核酸和 医学分子通过酰胺键或二硫键与金属盐结合物结合; 这种金属 - 盐配合物衍生物的制造方法。

公开(公告)号：EP2557155A4

公开(公告)日：2016-03-09

申请号：EP11765233

申请日：2011-04-06

申请人： IHI CORP ,  ISHIKAWA YOSHIHIRO

发明人： ISHIKAWA YOSHIHIRO ,  EGUCHI HARUKI ,  SATO HIROSHI

IPC分类号： C12N9/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/43 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K47/48 ,  A61P35/00 ,  C07F15/02

CPC分类号： A61K47/48076 ,  A61K9/0009 ,  A61K41/00 ,  A61K47/547

摘要： A metal-salen complex derivative with an excellent yield and stability is provided and a method for producing such a metal-salen complex derivative is provided. The present invention provides: metal-salen complex derivative obtained by allowing a target component composed of at least one of an enzyme, an antibody, an antigen, a peptide, an amino acid, an oligonucleotide, a protein, a nucleic acid, and a medical molecule to bind to a metal-salen complex via an amide bond or a disulfide bond; a method for producing such a metal-salen complex derivative.

公开(公告)号：EP3223862A1

公开(公告)日：2017-10-04

申请号：EP15801442.3

申请日：2015-11-27

申请人： GE Healthcare AS

发明人： MEIJER, Andreas Richard ,  THANING, Mikkel Jacob

IPC分类号： A61K49/10 ,  A61K49/18

CPC分类号： C07D257/02 ,  A61K47/48076 ,  A61K49/0002 ,  A61K49/101 ,  A61K49/108 ,  A61K49/18

摘要： The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods.

摘要翻译： 本发明涉及制备进一步包含少量过量游离螯合剂的大环螯合剂的镧系元素金属配合物制剂的方法。 该方法使用固相结合清除剂螯合剂去除过量的镧系元素金属离子，然后加入限定的过量螯合剂。 还提供了一种制备MRI造影剂的方法，以及可用于该方法的固相结合螯合剂葡甲胺盐。

公开(公告)号：EP2542248A4

公开(公告)日：2013-04-17

申请号：EP11751292

申请日：2011-03-02

申请人： UNIV KANSAS

发明人： BERKLAND CORY ,  MOHAMMADI ZAHRA

IPC分类号： A61K31/785

CPC分类号： A61K47/48076 ,  A61K9/0019 ,  A61K9/0056 ,  A61K31/785 ,  A61K47/547 ,  A61K47/58 ,  A61K47/595 ,  C08F8/00 ,  C08F18/22 ,  C08F26/02 ,  C08F126/02 ,  C08F2810/20 ,  C08G69/10 ,  C08G69/48 ,  C08G2210/00

摘要： Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use.