-
1.发明公开
公开(公告)号：EP3558394A1
公开(公告)日：2019-10-30
申请号：EP17822298.0
申请日：2017-12-21
申请人： GE Healthcare AS
发明人： MEIJER, Andreas Richard , THANING, Mikkel Jacob , BALES, Brian Christopher , RISHEL, Michael James
摘要： The invention provides compounds suitable for use as contrast agents in magnetic resonance imaging (MRI). The compounds of the present invention are manganese (II) complexes having advantageous properties as compared with similar known compounds.
-
公开(公告)号：EP3224250A1
公开(公告)日：2017-10-04
申请号：EP15804098.0
申请日：2015-11-27
申请人： GE Healthcare AS
IPC分类号： C07D257/00
CPC分类号： A61K49/108 , A61K9/0019 , A61K31/28 , A61K49/106 , C07D257/00
摘要： The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.
摘要翻译： 本发明涉及从大环螯合剂的镧系元素金属络合物中除去金属离子杂质如钙的方法。 该方法使用清除剂树脂除去过量的镧系元素离子从螯合剂中取代的金属离子。 还提供了通过加入确定的过量螯合剂由纯化的镧系金属配合物制备MRI造影剂的方法。
-
公开(公告)号：EP3223862A1
公开(公告)日：2017-10-04
申请号：EP15801442.3
申请日：2015-11-27
申请人： GE Healthcare AS
CPC分类号： C07D257/02 , A61K47/48076 , A61K49/0002 , A61K49/101 , A61K49/108 , A61K49/18
摘要： The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods.
摘要翻译： 本发明涉及制备进一步包含少量过量游离螯合剂的大环螯合剂的镧系元素金属配合物制剂的方法。 该方法使用固相结合清除剂螯合剂去除过量的镧系元素金属离子，然后加入限定的过量螯合剂。 还提供了一种制备MRI造影剂的方法，以及可用于该方法的固相结合螯合剂葡甲胺盐。
-
4.发明授权
公开(公告)号：EP3558394B1
公开(公告)日：2020-06-03
申请号：EP17822298.0
申请日：2017-12-21
申请人： GE Healthcare AS
-
-
6.发明公开
公开(公告)号：EP3223863A1
公开(公告)日：2017-10-04
申请号：EP15801443.1
申请日：2015-11-27
申请人： GE Healthcare AS
CPC分类号： A61K49/108 , A61K49/10 , A61K49/18
摘要： The present invention relates to a method of preparation of formulations of gadolinium metal complexes of the macrocyclic chelator DOTA, which further comprise a small excess of free DOTA. The method uses controlled conditions such that excess gadolinium is present as a precipitate of gadolinium oxide, with filtration to remove the excess, prior to the addition of a defined excess of DOTA chelator. Also provided is a method of preparation of MRI contrast agents based on Gd-DOTA.
摘要翻译： 本发明涉及制备大环螯合剂DOTA的钆金属配合物的制剂的方法，其进一步包含少量过量的游离DOTA。 该方法使用受控条件，使得过量的钆以氧化钆的沉淀物的形式存在，在添加限定过量的DOTA螯合剂之前通过过滤除去过量的钆。 还提供了基于Gd-DOTA制备MRI造影剂的方法。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.013 秒)
