公开(公告)号：EP2579844A1

公开(公告)日：2013-04-17

申请号：EP11726032.3

申请日：2011-06-10

申请人： Schobel, Alexander M. ,  Myers, Garry L. ,  Kendall, Keith Joseph ,  Rademacher, Thomas ,  Mous, Jan ,  Barry, Justin N.W. ,  Williams, Phillip ,  Barrientos, Africa Garcia

发明人： Schobel, Alexander M. ,  Myers, Garry L. ,  Kendall, Keith Joseph ,  Rademacher, Thomas ,  Mous, Jan ,  Barry, Justin N.W. ,  Williams, Phillip ,  Barrientos, Africa Garcia

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K38/28 ,  A61K47/48 ,  A61K9/70

CPC分类号： A61K38/28 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/2031 ,  A61K9/7007 ,  A61K38/00 ,  A61K38/26 ,  A61K47/48092 ,  A61K47/48861 ,  A61K47/4893 ,  A61K47/549 ,  A61K47/6923 ,  A61K47/6941 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/906

摘要： A therapeutic or bioeffecting film delivery system which includes nanoparticles having actives bound to or associated with the nanoparticles and which when administered allow the active to perform a therapeutic or bioeffecting function.

摘要翻译： 包括纳米颗粒的治疗性或生物效应薄膜递送系统，所述纳米颗粒具有与纳米颗粒结合或缔合的活性物质，并且当施用时允许活性物质执行治疗或生物功能作用。

公开(公告)号：EP2579844B1

公开(公告)日：2016-02-24

申请号：EP11726032.3

申请日：2011-06-10

申请人： Midatech Ltd. ,  MonoSol Rx, LLC

发明人： Rademacher Thomas ,  Mous Jan ,  Barry Justin ,  Williams Phillip ,  Barrientos Africa Garcia ,  Schobel Alexander M. ,  Myers Garry L. ,  Kendall Keith, J

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K38/28 ,  A61K47/48 ,  A61K9/70

CPC分类号： A61K38/28 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/2031 ,  A61K9/7007 ,  A61K38/00 ,  A61K38/26 ,  A61K47/48092 ,  A61K47/48861 ,  A61K47/4893 ,  A61K47/549 ,  A61K47/6923 ,  A61K47/6941 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/906

公开(公告)号：EP3154593A4

公开(公告)日：2018-02-14

申请号：EP15806704

申请日：2015-06-15

申请人： UNIV CALIFORNIA

发明人： LAL RATNESHWAR ,  LANDON PRESTON B ,  MO ALEXANDER

IPC分类号： A61K47/50 ,  A61K9/00 ,  A61K9/51 ,  A61K38/05 ,  A61K41/00 ,  A61K47/69

CPC分类号： A61K47/48015 ,  A61K9/0009 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5192 ,  A61K38/05 ,  A61K41/00 ,  A61K41/0028 ,  A61K47/48092 ,  A61K47/48884 ,  A61K47/4893 ,  A61K47/6923 ,  A61K47/6925 ,  A61K47/6941

摘要： Methods, systems, and devices are disclosed for fabricating and implementing nanoscale and microscale structured carriers to provide guided, targeted, and on-demand delivery of molecules and biochemical substances for a variety of applications including diagnosis and/or treatment (theranostics) of diseases in humans and animals. In some aspects, a nanostructure carrier can be synthesized in the form of a nanobowl, which may include an actuatable capping particle that can be opened (and in some implementations, closed) on demand. In some aspects, a nanostructure carrier can be synthesized in the form of a hollow porous nanoparticle with a functionalized interior and/or exterior to attach payload substances and substances for magnetically guided delivery and controlled release of substance payloads.

公开(公告)号：EP2913065A4

公开(公告)日：2016-07-27

申请号：EP13849310

申请日：2013-09-27

申请人： IMGT CO LTD

发明人： KIM HYUNCHEOL ,  MOON HYUNGWON ,  SONG TAI-KYONG ,  CHANG JIN HO ,  YOO YANG MO

IPC分类号： A61K49/22 ,  A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  A61K31/337 ,  A61K31/704 ,  A61K47/48 ,  A61K49/04 ,  A61K49/08 ,  A61P35/00

CPC分类号： A61K47/4893 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/704 ,  A61K47/6925 ,  A61K47/6929 ,  A61K47/6941 ,  A61K49/223 ,  A61K49/227

摘要： The present invention relates to an ultrasound contrast agent with drug-encapsulating nanoparticles and a method for preparing the same that increase drug delivery capabilities and drug penetration effects. According to the present investion, exposure to the foucused ultrasound triggers the cavitation of an ultrasound contrast agent, resulting in the local release of drug-encapsulating nanoparticles, which are conjugated onto the surface of the ultrasound contrast agent, and enhaced penetration of nanoparticles and drug delivery capbilities. Moreover, the present invention simultaneously and selectively diagnoses and treats cancers by conjugation cancer-targeting ligands on the surface of nanoparticles.

公开(公告)号：EP2913065A1

公开(公告)日：2015-09-02

申请号：EP13849310.1

申请日：2013-09-27

申请人： Sogang University Research Foundation

发明人： KIM, Hyuncheol ,  MOON, Hyungwon ,  SONG, Tai-Kyong ,  CHANG, jin Ho ,  YOO, Yang Mo

IPC分类号： A61K49/04 ,  A61K49/08 ,  A61K9/16 ,  A61P35/00

CPC分类号： A61K47/4893 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/704 ,  A61K47/6925 ,  A61K47/6929 ,  A61K47/6941 ,  A61K49/223 ,  A61K49/227

摘要： The present invention relates to an ultrasound contrast agent with drug-encapsulating nanoparticles and a method for preparing the same that increase drug delivery capabilities and drug penetration effects. According to the present investion, exposure to the foucused ultrasound triggers the cavitation of an ultrasound contrast agent, resulting in the local release of drug-encapsulating nanoparticles, which are conjugated onto the surface of the ultrasound contrast agent, and enhaced penetration of nanoparticles and drug delivery capbilities. Moreover, the present invention simultaneously and selectively diagnoses and treats cancers by conjugation cancer-targeting ligands on the surface of nanoparticles.

摘要翻译： 本发明涉及具有药物包封纳米颗粒的超声造影剂及其制备方法，其增加药物递送能力和药物渗透效应。 根据目前的投资，接触超声造影剂的超声引发超声造影剂的气蚀，导致药物包封的纳米颗粒的局部释放，其结合到超声造影剂的表面上，并且覆盖纳米颗粒和药物的渗透 交付能力。 此外，本发明通过纳米颗粒表面上缀合癌靶向配体同时并选择性地诊断和治疗癌症。