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    ARTIFICIAL LUNG
    4.
    发明授权
    ARTIFICIAL LUNG 有权

    公开(公告)号：EP2692370B1

    公开(公告)日：2018-08-22

    申请号：EP12765191.7

    申请日：2012-03-27

    申请人： Terumo Kabushiki Kaisha

    发明人： TAKEUCHI Kazuhiko

    IPC分类号： A61M1/18 ,  B01D63/02 ,  B01D71/26 ,  A61M1/36 ,  B01D69/08 ,  A61M1/16

    CPC分类号： A61M1/1698 ,  B01D63/02 ,  B01D63/026 ,  B01D69/081 ,  B01D71/26

    摘要： An oxygenator includes: a housing; a hollow fiber membrane layer that is stored in the housing and has multiple integrated hollow fiber membranes 31 with a gas exchange function; a gas inlet portion and a gas outlet portion that are provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes 31, respectively; and a blood inlet portion and a blood outlet portion that are provided on the upstream and downstream of blood passages outsides of the hollow fiber membranes 31, respectively. The hollow fiber membranes 31 in the hollow fiber membrane layer are fixed to each other at one end portions and the other end portions thereof. Conditions 30 ‰¤ µ ‰¤ 60 and OD ‰¤ 4.5 × µ are met where µ [µm] is an average separation distance between the adjacent hollow fiber membranes 31 at a fixed portion of the hollow fiber membrane layer and OD [µm] is the outer diameter of the hollow fiber membranes 31,.

    HOLLOW FIBER MEMBRANE FOR USE IN AN ANESTHETIC CIRCUIT
    9.
    发明公开
    HOLLOW FIBER MEMBRANE FOR USE IN AN ANESTHETIC CIRCUIT 审中-公开
    空心纤维膜用于麻醉电路

    公开(公告)号：EP3235558A1

    公开(公告)日：2017-10-25

    申请号：EP16166434.7

    申请日：2016-04-21

    申请人： 3M Innovative Properties Company ,  DMF Medical Incorporated

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： B01D69/08 ,  B01D53/22 ,  B01D71/26

    CPC分类号： B01D69/08 ,  B01D53/22 ,  B01D53/228 ,  B01D69/087 ,  B01D71/26 ,  B01D2053/224 ,  B01D2256/10 ,  B01D2257/504 ,  B01D2259/4533 ,  B01D2325/022 ,  B01D2325/20 ,  Y02C10/10

    摘要： Hydrophobic poly(4-methyl-1-pentene) hollow fiber membrane for retention of anesthetic agents with an inner and an outer surface and between inner and outer surface an essentially isotropic support layer with a sponge-like, open-pored, microporous structure free of macrovoids and adjacent to this support layer on the outer surface a dense separation layer with a thickness between 1.0 and 3.5 µm. The membrane has a porosity in the range of greater than 35% to less than 50% by volume and a permeance for CO 2 of 20-60 mol/(h·m 2 ·bar), a gas separation factor α(CO 2 /N 2 ) of at least 5 and a selectivity CO 2 / anesthetic agents of at least 150.
    The process for producing this membrane is based on a thermally induced phase separation process in which process a homogeneous solution of a poly(4-methyl-1-pentene) in a solvent system containing compounds A and B is formed, wherein compound A is a strong solvent and compound B a weak non-solvent for the polymer component. After formation of a hollow fiber the hollow fiber is cooled in a liquid cooling medium to form a hollow fiber membrane. The concentration of the polymer component in the solution may be between 42.5- and 45.8 wt.-% and the hollow fiber leaving the die runs through a gap between die and cooling medium with a gap length in the range of 5-30 mm.

    摘要翻译： 疏水性聚（4-甲基-1-戊烯）中空纤维膜，用于保持具有内表面和外表面以及内外表面之间的麻醉剂，基本上是各向同性的支持层，其具有类似海绵状的开孔微孔结构 的大孔并且在该外表面上与该支撑层相邻处具有厚度在1.0和3.5μm之间的致密隔离层。 膜的孔隙率在35体积％以上且小于50体积％的范围内，CO 2的渗透性为20〜60摩尔/（h·m 2·巴），气体分离系数α（CO 2 / N 2）为 至少为5，选择性CO 2 /麻醉剂的选择性至少为150.生产该膜的方法基于热诱导相分离过程，在该过程中，聚（4-甲基-1-戊烯）在 形成含有化合物A和B的溶剂体系，其中化合物A是强溶剂，化合物B是聚合物组分弱的非溶剂。 在形成中空纤维之后，中空纤维在液体冷却介质中冷却以形成中空纤维膜。 溶液中聚合物组分的浓度可以在42.5重量％和45.8重量％之间，离开模头的中空纤维通过模头和冷却介质之间的间隙，间隙长度在5-30mm范围内。