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    AUTOMATED OLIGOSACCHARIDE SYNTHESIZER
    3.
    发明公开
    AUTOMATED OLIGOSACCHARIDE SYNTHESIZER 审中-公开
    自动寡糖合成仪

    公开(公告)号：EP2321042A1

    公开(公告)日：2011-05-18

    申请号：EP09801001.0

    申请日：2009-07-23

    申请人： Ancora Pharmaceuticals Inc.

    发明人： CHRIST, William ,  KRÖCK, Lenz ,  PLANTE, Obadiah, J. ,  CASTAGNER, Bastien ,  SEEBERGER, Peter, H.

    IPC分类号： B01J19/18 ,  C13K13/00

    CPC分类号： B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00391 ,  B01J2219/00394 ,  B01J2219/00412 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00454 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00722 ,  B01J2219/00731

    摘要： The technical field of this invention is automated oligosaccharide synthesizers. There is a need in this field for more efficient oligosaccharide synthesizers. For example, the present invention is an apparatus for solid phase oligosaccharide synthesis, which includes a reaction vessel for holding a reaction mixture, such that the reaction vessel is equipped with a temperature control system, a donor vessel for holding a saccharide donor; an activation vessel for holding activator, a pump operably connected to a fluidic valve; an additional fluidic valve connected to the activation vessel, to the first fluidic valve via a first fluid line, and to the reaction vessel via a second fluid line, such that the activator or saccharide donor can be delivered via the second fluidic valve into the first fluid line and then through the second fluid line into the reaction vessel.

    摘要翻译： 本发明的技术领域是自动寡糖合成仪。 该领域需要更有效的寡糖合成仪。 例如，本发明是一种用于固相寡糖合成的设备，其包括用于保持反应混合物的反应容器，使得反应容器配备有温度控制系统，用于保持糖类供体的供体容器; 用于容纳活化剂的活化容器，可操作地连接到流体阀的泵; 连接到活化容器的附加流体阀，经由第一流体管线连接到第一流体阀，并且经由第二流体管线连接到反应容器，使得活化剂或糖供体可以经由第二流体阀输送到第一流体阀 流体管线，然后通过第二流体管线进入反应容器。

    Valve block assemblies
    8.
    发明公开
    Valve block assemblies 失效
    Ventilblockzusammenbau。

    公开(公告)号：EP0257797A2

    公开(公告)日：1988-03-02

    申请号：EP87306518.9

    申请日：1987-07-23

    申请人： PORTON INSTRUMENTS, INC.

    发明人： Farnsworth, Vincent Robert ,  Cartier, Paul Kelso III

    IPC分类号： B01J4/00 ,  B01J19/00

    CPC分类号： B01J19/0046 ,  B01J2219/00394 ,  B01J2219/00398 ,  B01J2219/0059 ,  B01J2219/00725 ,  C40B40/10 ,  C40B60/14 ,  Y10T137/3124 ,  Y10T137/314 ,  Y10T137/86332 ,  Y10T137/87684

    摘要： A valve block assembly having internal delivery channels and a common outlet channel is provided with two delivery valve surfaces with access to the common channel. The common channel comprises easily cleaned linear sections 26, 126 running alternately from one surface to the other, and connecting surface grooves 25, 125 at the valve sites. Diaphragm valves 19, 20, 21 are provided with relief grooves 4a to accommodate deformation of the diaphragm 5. The V-like cross-section of the connecting grooves 25, 125 of the common channel and the conical shape of the nearby outlet 24a of a delivery channel 24 assure that the valve may be opened by only a small actuating force. Reservoirs 10 feeding the delivery channels 24 have an inert atmosphere controlled by pressurizing and venting channels 22, 23 in the valve block 16, 116. Exposure of plastic tubing to oxygen is kept to a minimum. The assembly is particularly adapted for use in a protein sequencer to supply reactants without cross-contamination or oxidative decomposition.

    摘要翻译： 具有内部输送通道和公共出口通道的阀块组件设置有两个具有进入公共通道的输送阀表面。 公共通道包括从一个表面到另一个表面交替运行的容易清洁的线性段26,126以及在阀位处的连接表面槽25,125。 隔膜阀19,20,21设置有释放槽4a以适应隔膜5的变形。公共通道的连接槽25,125的V形横截面和附近出口24a的锥形形状 输送通道24确保阀只能通过小的致动力打开。 供给输送通道24的储存器10具有通过对阀块16,116中的通道22,23进行加压和排气来控制的惰性气体。将塑料管道暴露于氧气中保持最小。 该组合物特别适用于蛋白质测序仪，以提供反应物而不会发生交叉污染或氧化分解。