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    MRI CONTRAST AGENT INCLUDING T1 CONTRAST MATERIAL COATED ON SURFACE OF NANOPARTICLE SUPPORT
    4.
    发明公开
    MRI CONTRAST AGENT INCLUDING T1 CONTRAST MATERIAL COATED ON SURFACE OF NANOPARTICLE SUPPORT 审中-公开
    MRI造影剂T1对比材料涂布在纳米粒子载体的表面

    公开(公告)号：EP2942064A4

    公开(公告)日：2016-01-20

    申请号：EP14735209

    申请日：2014-01-03

    申请人： UNIV YONSEI IACF

    发明人： CHEON JIN WOO ,  SHIN TAE HYUN

    IPC分类号： A61K49/18

    CPC分类号： A61K49/1878 ,  A61K49/08 ,  A61K49/126 ,  A61K49/14

    摘要： The present invention relates to a magnetic resonance imaging (MRI) T1 contrast agent composition including T1 contrast material coated on the surface of a nanoparticle support. The MRI T1 contrast agent composition of the present invention has excellent T1 spin magnetic relaxation effects by modifying the paramagnetic T1 contrast material on the nanoparticle support having a certain diameter such that the paramagnetic T1 contrast material has a certain thickness or less, and thereby remarkably increasing the surface-to-volume ratio of the T1 contrast material. The present invention provides more precise and clear T1 positive contrast images, and is thus useful for highly reliable image diagnosis.

    DRUG CARRIER PROVIDING MRI CONTRAST ENHANCEMENT
    8.
    发明公开
    DRUG CARRIER PROVIDING MRI CONTRAST ENHANCEMENT 有权
    WIRKSTOFFTRERGERFÜRVERBESSERTEN MRI-KONTRAST

    公开(公告)号：EP2340051A1

    公开(公告)日：2011-07-06

    申请号：EP09787082.8

    申请日：2009-09-03

    申请人： Koninklijke Philips Electronics N.V. ,  Philips Intellectual Property & Standards GmbH

    发明人： LANGEREIS, Sander ,  KEUPP, Jochen ,  GRUELL, Holger ,  BURDINSKI, Dirk ,  BEELEN, Danielle

    IPC分类号： A61K49/06 ,  A61K49/18 ,  A61K9/127

    CPC分类号： A61K49/08 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1273 ,  A61K41/0028 ,  A61K49/10 ,  A61K49/12 ,  A61K49/1812

    摘要： Described are drug carriers useful in magnetic resonance imaging (MRI)-guided drug release comprising a shell capable of releasing an enclosed biologically active agent as a result of a local stimulus, e.g. energy input, such as heat, wherein the shell encloses a 19F MR contrast agent. Preferably, the carrier also acts as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). To this end the shell encloses a cavity that comprises a paramagnetic chemical shift reagent, a pool of proton analytes, and the 19F contrast agent, and wherein the shell allows diffusion of the proton analytes.

    摘要翻译： 描述了可用于磁共振成像（MRI）指导的药物释放的药物载体，其包含能够释放作为局部刺激的结果的封闭的生物活性剂的壳，例如， 能量输入，例如热量，其中壳体包围19F MR造影剂。 优选地，基于化学交换依赖性饱和转移（CEST）的原理，载体也用作MRI的对比度增强剂。 为此，壳体包围包含顺磁性化学位移试剂，质子分析物池和19F造影剂的空腔，并且其中壳体允许质子分析物的扩散。