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    SPRAY DRYING TECHNIQUES
    1.
    发明公开
    SPRAY DRYING TECHNIQUES 审中-公开
    喷雾干燥工艺

    公开(公告)号：EP2654939A2

    公开(公告)日：2013-10-30

    申请号：EP11813839.5

    申请日：2011-12-20

    Applicant: President and Fellows of Harvard College ,  BASF SE

    Inventor： ABATE, Adam, R. ,  THIELE, Julian, W.P. ,  WEITZ, David, A. ,  WINDBERGS, Maike ,  HOLTZE, Christian

    IPC: B01J2/04 ,  B05B7/04

    CPC classification number: B01D1/18 ,  A61K31/58 ,  F26B3/12

    Abstract: The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfiuidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.

    SYSTEMS AND METHODS FOR SPRAY DRYING IN MICROFLUIDIC AND OTHER SYSTEMS
    3.
    发明公开
    SYSTEMS AND METHODS FOR SPRAY DRYING IN MICROFLUIDIC AND OTHER SYSTEMS 审中-公开
    系统和方法在微流控等系统喷雾干燥

    公开(公告)号：EP2897719A2

    公开(公告)日：2015-07-29

    申请号：EP13774283.9

    申请日：2013-09-19

    Applicant: President and Fellows of Harvard College ,  BASF SE

    Inventor： AMSTAD, Esther ,  HOLTZE, Christian ,  WEITZ, David, A.

    IPC: B01J2/02

    CPC classification number: B01D1/20 ,  B01J2/02 ,  B01J2/04 ,  F26B3/12

    Abstract: The present invention generally relates to microfluidics, and to spray drying and other drying techniques. By at least partially drying fluids within a microfluidic channel, instead of or in addition to conventional spray drying techniques, better control of the drying process can be achieved in certain aspects of the invention. In addition, various embodiments of the invention are generally directed to systems and methods for drying fluids contained within a channel such as a microfluidic channel. For example, a fluid may be partially or completely dried within a microfluidic channel, prior to being sprayed into a collection region. In some embodiments, gases such as air may be directed into a channel containing a fluid, which may facilitate drying of the fluid. In some cases, the fluid may be accelerated due to the introduction of gases into the channel, and in certain embodiments, droplets of fluid may be disrupted to form smaller droplets as a result. In certain cases, the fluids may also be dried to form supersaturated droplets.

    SYSTEMS AND METHODS FOR SHELL ENCAPSULATION
    6.
    发明公开
    SYSTEMS AND METHODS FOR SHELL ENCAPSULATION 审中-公开
    用于壳体封装的系统和方法

    公开(公告)号：EP2750787A2

    公开(公告)日：2014-07-09

    申请号：EP12751233.3

    申请日：2012-08-15

    Applicant: President and Fellows of Harvard College ,  BASF SE

    Inventor： WEITZ, David, A. ,  SHUM, Ho, Cheung ,  ZHAO, Yuanjin ,  SUN, Bingjie ,  HOLTZE, Christian

    IPC: B01J13/20

    CPC classification number: B01J13/203 ,  A01N25/28 ,  A23L29/015 ,  A23P10/30 ,  A61K9/501 ,  A61K9/5036 ,  A61K9/5089 ,  C09B67/0097 ,  C11D17/0039 ,  A01N59/02 ,  A01N59/06 ,  A01N59/16

    Abstract: The present invention generally relates to particles, including particles for drug delivery and other applications. Certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to enhance the containment of the interior, for example to reduce transport of an agent into or out of the interior. Such particles may exhibit increased ability to encapsulate agents and/or increased storage life (e.g., due to reduced leakage). For instance, in certain embodiments, any defects, such as cracks, pores, etc. within the shell may be sealed or otherwise treated to reduce transport therethrough, for example, with a solid. In some embodiments, for instance, a first reactant in the interior of a particle may come into contact with a second reactant outside of the particle to form a solid, or other suitable product. The shell may also be treated, e.g., at a later point in time, to cause release of an agent contained within the interior, in certain aspects. For example, the shell may be heated to cause the release of the agent from the particle, or the shell may be exposed to chemical or enzymatic degradation, or a change in osmolarity, to cause release of an agent. Still other aspects of the present invention are generally directed to methods of making or using such particles, kits or devices including such particles, or the like.

    Abstract translation: 本发明一般涉及颗粒，包括用于药物递送和其他应用的颗粒。 本发明的某些方面通常涉及包含壳和至少部分由壳包含的内部的颗粒。 在一些实施方案中，可对颗粒进行处理以增强内部的容纳，例如以减少试剂进入或离开内部的运输。 这样的颗粒可以表现出增加的包封剂的能力和/或增加的存储寿命（例如，由于泄漏降低）。 例如，在某些实施例中，壳体内的任何缺陷（例如裂纹，孔隙等）可被密封或以其他方式处理以减少通过其中的运输，例如用固体。 在一些实施例中，例如，颗粒内部的第一反应物可以与颗粒外部的第二反应物接触以形成固体或其他合适的产物。 在某些方面，壳还可以例如在稍后的时间点被处理，以引起包含在内部内的试剂的释放。 例如，壳可以被加热以引起药剂从颗粒中释放，或壳可以暴露于化学或酶降解或渗透压变化，以引起药剂的释放。 本发明的其他方面通常涉及制造或使用这种颗粒，包括这种颗粒的试剂盒或装置等的方法。

    CONTROL OF EMULSIONS, INCLUDING MULTIPLE EMULSIONS
    7.
    发明公开
    CONTROL OF EMULSIONS, INCLUDING MULTIPLE EMULSIONS 有权
    芫荽粉，茉莉酸

    公开(公告)号：EP2714254A2

    公开(公告)日：2014-04-09

    申请号：EP12725967.9

    申请日：2012-05-22

    Applicant: President and Fellows of Harvard College ,  BASF SE

    Inventor： ROTEM, Assaf ,  WEITZ, David A. ,  ABATE, Adam R. ,  HOLTZE, Christian

    IPC: B01F13/00 ,  B01F3/08

    CPC classification number: B01F3/0811 ,  B01F3/0807 ,  B01F13/0062 ,  B01F13/0084 ,  Y10T137/87571

    Abstract: The present invention generally relates to emulsions, and more particularly, to double and other multiple emulsions. Certain aspects of the present invention are generally directed to the creation of double emulsions and other multiple emulsions at a common junction of microfluidic channels. In some cases, the microfluidic channels at the common junction may have substantially the same hydrophobicity. In one set of embodiments, a device may include a common junction of six or more channels, where a first fluid flows through one channel, a second fluid flows through two channels, and a third or carrying fluid flows through two more channels, such that a double emulsion of a first droplet of the first fluid, contained in a second droplet of the second fluid, contained by the carrying fluid, flows away from the common junction through a sixth channel. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.

    Abstract translation: 本发明一般涉及乳液，更具体地说涉及双重和其它多重乳液。 本发明的某些方面通常涉及在微流体通道的共同连接处产生双重乳液和其它多重乳液。 在一些情况下，共同连接处的微流体通道可具有基本上相同的疏水性。 在一组实施例中，装置可以包括六个或更多个通道的公共接头，其中第一流体流过一个通道，第二流体流过两个通道，并且第三或承载流体流过两个以上通道，使得 包含在第二流体的第二液滴中的第一流体的第一液滴的双重乳液由携带流体包含，通过第六通道从公共接头流出。

    MELT EMULSIFICATION
    8.
    发明公开
    MELT EMULSIFICATION 审中-公开
    融乳化

    公开(公告)号：EP2547436A2

    公开(公告)日：2013-01-23

    申请号：EP11716682.7

    申请日：2011-03-17

    Applicant: President and Fellows of Harvard College ,  BASF SE

    Inventor： SHUM, Ho, Cheung ,  SUN, Bingjie ,  WEITZ, David, A. ,  HOLTZE, Christian

    IPC: B01J13/00 ,  B01J13/04 ,  A01N25/28 ,  A61K9/50 ,  C09B67/00 ,  C11D3/50 ,  C11D17/00

    CPC classification number: B01J13/0086 ,  B01F3/0807 ,  B01F13/0062 ,  B01F2005/0034 ,  B01J13/04 ,  C09B67/0009 ,  C09B67/0097 ,  G01N2015/1413

    Abstract: The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.

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