公开(公告)号：EP3099789A4

公开(公告)日：2017-09-13

申请号：EP15743978

申请日：2015-01-29

申请人： UNIV GEORGIA

发明人： SELLERS HOLLY S

IPC分类号： C12N7/08 ,  A61K39/00 ,  A61K39/12 ,  A61K39/15 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  G01N33/569

CPC分类号： A61K39/15 ,  A61K39/12 ,  A61K2039/552 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  C12N2720/12221 ,  C12N2720/12222 ,  C12N2720/12234 ,  C12N2720/12264 ,  G01N33/56983 ,  G01N2333/14 ,  G01N2469/00

摘要： The present invention relates to novel strains of avian reovirus that were isolated from clinical cases of viral arthritis/tenosynovitis in chickens in the southeast United States. The invention is directed to these novel group 1 and group 2 avian reoviruses, diagnostic assays using antibodies and/or nucleotide- or amino acid-specific components of such viruses, such as the S1 gene encoding the sigma C protein, and to vaccines that protect chickens from disease caused by such viruses.

摘要翻译： 本发明涉及从美国东南部的鸡的病毒性关节炎/腱鞘炎的临床病例中分离的新型禽呼肠孤病毒株。 本发明涉及这些新的1族和2族禽呼肠孤病毒，使用这些病毒的抗体和/或核苷酸或氨基酸特异性组分的诊断测定，例如编码西格玛C蛋白的S1基因，以及保护 由这种病毒引起的疾病引起的鸡。

公开(公告)号：EP2952583A1

公开(公告)日：2015-12-09

申请号：EP15176066.7

申请日：2008-03-11

申请人： Oncolytics Biotech Inc.

发明人： COFFEY, Matthew C.

IPC分类号： C12N15/46 ,  A61K35/76 ,  A61P35/00 ,  C07K14/14 ,  C12N15/86 ,  C12N7/01

CPC分类号： C12N7/00 ,  A61K35/13 ,  A61K35/765 ,  A61K45/06 ,  C07K14/005 ,  C12N2720/12221 ,  C12N2720/12222

摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

摘要翻译： 本发明提供修饰的呼肠孤病毒核酸序列和修饰的呼肠孤病毒多肽序列以及含有这种修饰的核酸或多肽序列的呼肠病毒。 本发明还提供了药物组合物，其包括具有修饰序列的呼肠孤病毒以及制造和使用这些呼肠孤病毒的方法。

公开(公告)号：EP2132315A4

公开(公告)日：2011-10-05

申请号：EP08733587

申请日：2008-03-11

申请人： ONCOLYTICS BIOTECH INC

发明人： COFFEY MATTHEW C

IPC分类号： C12N15/46 ,  A61K35/76 ,  A61P35/00 ,  C07K14/14 ,  C12N7/01 ,  C12N15/86

CPC分类号： C12N7/00 ,  A61K35/13 ,  A61K35/765 ,  A61K45/06 ,  C07K14/005 ,  C12N2720/12221 ,  C12N2720/12222

摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

公开(公告)号：EP0687728A3

公开(公告)日：1996-12-18

申请号：EP95201282.1

申请日：1995-05-17

申请人： Akzo Nobel N.V. ,  UNIVERSITY OF DELAWARE

发明人： Rosenberger, John Knox ,  Roessler, Donald Eugene ,  Hein, Rudolf George

IPC分类号： C12N7/00 ,  A61K39/15 ,  A61K39/295 ,  A61K35/76

CPC分类号： C07K16/10 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/552 ,  A61K2039/70 ,  C07K2317/23 ,  C12N7/00 ,  C12N2720/12221 ,  C12N2720/12234

摘要： Disclosed herein is the isolation of a relatively non-pathogenic reovirus, designated strain 2177, and vaccines comprising this strain.

公开(公告)号：EP3220949A4

公开(公告)日：2018-07-11

申请号：EP15860630

申请日：2015-11-17

申请人： VIRGINIA TECH INTELLECTUAL PROPERTIES INC

发明人： MENG XIANG-JIN ,  CAO DIANJUN ,  NARAYANAPPA ATHMARAM ,  SUBBIAH ELANKUMARAN

IPC分类号： C12N7/00 ,  A61K39/15 ,  C07K14/14 ,  C12Q1/68 ,  G01N33/569

CPC分类号： G01N33/56983 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  C12N2720/12221 ,  C12N2720/12222 ,  C12N2720/12234 ,  C12N2720/12263 ,  C12N2720/12264 ,  C12Q1/701 ,  G01N2333/14 ,  G01N2469/20

摘要： Provided herein are diagnostics and vaccines to identify control and prevent novel porcine orthoreovirus type 3 (POV3) isolated from diarrheic feces of piglets from outbreaks in three states and ring-dried swine blood meal from multiple sources.

公开(公告)号：EP2132315B1

公开(公告)日：2015-07-15

申请号：EP08733587.3

申请日：2008-03-11

申请人： Oncolytics Biotech Inc.

发明人： COFFEY, Matthew C.

IPC分类号： C12N15/46 ,  A61K35/76 ,  A61P35/00 ,  C07K14/14 ,  C12N15/86 ,  C12N7/01

CPC分类号： C12N7/00 ,  A61K35/13 ,  A61K35/765 ,  A61K45/06 ,  C07K14/005 ,  C12N2720/12221 ,  C12N2720/12222

摘要： The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

公开(公告)号：EP0687728B1

公开(公告)日：2009-07-15

申请号：EP95201282.1

申请日：1995-05-17

申请人： Intervet International BV ,  UNIVERSITY OF DELAWARE

发明人： Rosenberger, John Knox ,  Roessler, Donald Eugene ,  Hein, Rudolf George

IPC分类号： C12N7/00 ,  A61K39/15 ,  A61K39/295 ,  A61K35/76

CPC分类号： C07K16/10 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/552 ,  A61K2039/70 ,  C07K2317/23 ,  C12N7/00 ,  C12N2720/12221 ,  C12N2720/12234

摘要： Disclosed herein is the isolation of a relatively non-pathogenic reovirus, designated strain 2177, and vaccines comprising this strain.

公开(公告)号：EP3220949A1

公开(公告)日：2017-09-27

申请号：EP15860630.1

申请日：2015-11-17

申请人： Virginia Tech Intellectual Properties, Inc.

发明人： MENG, Xiang-Jin ,  CAO, Dianjun ,  NARAYANAPPA, Athmaram ,  SUBBIAH, Elankumaran

IPC分类号： A61K39/15 ,  C12Q1/68 ,  G01N33/569

CPC分类号： G01N33/56983 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  C12N2720/12221 ,  C12N2720/12222 ,  C12N2720/12234 ,  C12N2720/12263 ,  C12N2720/12264 ,  C12Q1/701 ,  G01N2333/14 ,  G01N2469/20

摘要： Provided herein are diagnostics and vaccines to identify control and prevent novel porcine orthoreovirus type 3 (POV3) isolated from diarrheic feces of piglets from outbreaks in three states and ring-dried swine blood meal from multiple sources.

摘要翻译： 本文提供了诊断和疫苗，用于鉴定对照并预防从三种状态的爆发以及来自多个来源的环干猪血粉中分离出的小猪的腹泻粪便分离的新型猪正3型病毒（POV3）。

公开(公告)号：EP3099789A1

公开(公告)日：2016-12-07

申请号：EP15743978.7

申请日：2015-01-29

申请人： University Of Georgia Research Foundation, Inc.

发明人： SELLERS, Holly, S.

IPC分类号： C12N7/08 ,  C12N7/00 ,  A61K39/15

CPC分类号： A61K39/15 ,  A61K39/12 ,  A61K2039/552 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  C12N2720/12221 ,  C12N2720/12222 ,  C12N2720/12234 ,  C12N2720/12264 ,  G01N33/56983 ,  G01N2333/14 ,  G01N2469/00

摘要： The present invention relates to novel strains of avian reovirus that were isolated from clinical cases of viral arthritis/tenosynovitis in chickens in the southeast United States. The invention is directed to these novel group 1 and group 2 avian reoviruses, diagnostic assays using antibodies and/or nucleotide- or amino acid-specific components of such viruses, such as the S1 gene encoding the sigma C protein, and to vaccines that protect chickens from disease caused by such viruses.

摘要翻译： 本发明涉及从美国东南部的鸡的病毒性关节炎/腱鞘炎的临床病例中分离的新型禽呼肠孤病毒株。 本发明涉及这些新的第1组和第2组禽呼肠孤病毒，使用这些病毒的核苷酸或氨基酸特异性组分（如编码西格玛C蛋白的S1基因）的诊断测定法，以及保护鸡免受疾病引起的疫苗 通过这种病毒。

公开(公告)号：EP2304024A2

公开(公告)日：2011-04-06

申请号：EP09771149.3

申请日：2009-06-26

申请人： Biomune Company ,  Ceva Sante Animale

发明人： DORSEY, Kristi, Mae ,  ROSENBERGER, John, Knox ,  ROSENBERGER, Sandra, Cloud

IPC分类号： C12N7/00 ,  C12N15/46 ,  C07K14/14 ,  C07K16/10 ,  A61K39/15 ,  A61K39/295 ,  G01N33/569 ,  C12Q1/70 ,  C12N5/06

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C12N2720/12221 ,  C12N2720/12222 ,  C12N2720/12234 ,  C12N2770/12034 ,  G01N33/569 ,  G01N2333/14

摘要： This invention relates to novel unique strains avian reoviridae that were isolated from severe cases of Runting Stunting Syndrome. The present invention also relates to the isolation and uses of novel unique avian reoviridae, diagnostic assays using nucleotide or amino acid specific components of such viruses, such as the sequence encoding Sigma C capsid protein and to vaccines that protect birds from diseases caused by such viruses.