公开(公告)号：EP1668120B1

公开(公告)日：2012-01-18

申请号：EP04816108.7

申请日：2004-08-17

申请人： NEW YORK UNIVERSITY

发明人： MERUELO, Daniel ,  TSENG, Jen-Chieh

IPC分类号： C12N15/09

CPC分类号： A61K49/0047 ,  A61K47/6901 ,  A61K49/0013 ,  A61K49/0097 ,  C12N2770/32132 ,  C12N2770/36143

摘要： Disclosed herein are methods for identifying cancer cells and monitoring anticancer therapy in the body of a mammal by systemically delivering Sindbis viral vectors. The vector can specifically target and identify tumor cells in mice growing subcutaneously, intraperitoneally, intrapancreatically, or in the lungs. These findings demonstrate the remarkable specificity of the Sindbis vector system that is relatively safe and can specifically target tumor cells throughout the body via the bloodstream.

公开(公告)号：EP1668120A4

公开(公告)日：2007-01-10

申请号：EP04816108

申请日：2004-08-17

申请人： UNIV NEW YORK

发明人： MERUELO DANIEL ,  TSENG JEN-CHIEH

IPC分类号： C12N15/09 ,  A61K20060101 ,  A61K48/00 ,  A61K49/00 ,  A61K51/00 ,  A61M36/14 ,  C12N7/00 ,  C12N15/63 ,  C12Q1/70

CPC分类号： A61K49/0047 ,  A61K47/6901 ,  A61K49/0013 ,  A61K49/0097 ,  C12N2770/32132 ,  C12N2770/36143

公开(公告)号：EP1668120A2

公开(公告)日：2006-06-14

申请号：EP04816108.7

申请日：2004-08-17

申请人： NEW YORK UNIVERSITY

发明人： MERUELO, Daniel ,  TSENG, Jen-Chieh

IPC分类号： C12N7/00 ,  C12N15/63 ,  A61K48/00

CPC分类号： A61K49/0047 ,  A61K47/6901 ,  A61K49/0013 ,  A61K49/0097 ,  C12N2770/32132 ,  C12N2770/36143

摘要： Disclosed herein are methods for identifying cancer cells and monitoring anticancer therapy in the body of a mammal by systemically delivering Sindbis viral vectors. The vector can specifically target and identify tumor cells in mice growing subcutaneously, intraperitoneally, intrapancreatically, or in the lungs. These findings demonstrate the remarkable specificity of the Sindbis vector system that is relatively safe and can specifically target tumor cells throughout the body via the bloodstream.