公开(公告)号：EP3096742B1

公开(公告)日：2024-06-12

申请号：EP15737194.9

申请日：2015-01-20

IPC分类号： A61K9/127 ,  G01N33/53 ,  A61K49/00 ,  A61K35/28 ,  C12N5/00 ,  C12N5/0775 ,  A61K35/12 ,  A61K47/64 ,  A61K47/69

CPC分类号： C12N5/0006 ,  C12N5/0663 ,  A61K2035/12420130101 ,  A61K49/0041 ,  A61K49/0047 ,  A61K49/0084 ,  A61K47/64 ,  A61K47/6911 ,  A61K47/6425

公开(公告)号：EP3149025A4

公开(公告)日：2018-02-21

申请号：EP15796259

申请日：2015-05-21

申请人： CYCLOPORTERS INC

发明人： PEI DEHUA ,  QIAN ZIQING

IPC分类号： A61K38/05 ,  A61K38/12 ,  A61K38/46 ,  C07K7/00

CPC分类号： C07K7/64 ,  A61K38/00 ,  A61K38/05 ,  A61K38/12 ,  A61K38/465 ,  A61K47/48246 ,  A61K47/64 ,  A61K49/0039 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0047 ,  A61K49/0056 ,  C07K7/06 ,  C12Y301/03048

摘要： Disclosed herein are compounds having activity as cell penetrating peptides. In some examples, the compounds can comprise a cell penetrating peptide moiety and a cargo moiety. The cargo moiety can comprise one or more detectable moieties, one or more therapeutic moieties, one or more targeting moieties, or any combination thereof. In some examples, the cell penetrating peptide moiety is cyclic. In some examples, the cell penetrating peptide moiety and cargo moiety together are cyclic. In some examples, the cell penetrating peptide moiety is cyclic and the cargo moiety is appended to the cyclic cell penetrating peptide moiety structure. In some examples, the cargo moiety is cyclic and the cell penetrating peptide moiety is cyclic, and together they form a fused bicyclic system.

公开(公告)号：EP3281693A1

公开(公告)日：2018-02-14

申请号：EP16776609.6

申请日：2016-04-07

申请人： Sonocore Inc. ,  Fukuoka University

发明人： TACHIBANA, Katsuro

IPC分类号： B01F3/04 ,  A61B8/06 ,  A61K49/00 ,  B01F11/00 ,  A61K9/10 ,  A61K9/127 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/42

CPC分类号： A61K9/5089 ,  A61B8/06 ,  A61J1/14 ,  A61K9/10 ,  A61K9/127 ,  A61K9/5052 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/42 ,  A61K49/00 ,  A61K49/0047 ,  A61K49/223 ,  A61N7/00 ,  A61N2007/0039 ,  B01F3/04 ,  B01F11/00 ,  B65B3/003 ,  B65D51/002

摘要： A bubble manufacturing container 20 of the present invention includes: a container body 21 having an opening portion; and a rubber stopper 221 provided on the opening portion of the container body 21. The rubber stopper 221 is constituted so that the bubbles 1 of an inside of the container body 21 are able to be taken by piercing an injection needle. It is preferred that the bubble manufacturing container 20 has a fastening portion 222 provided on the rubber stopper 221, having an opening and sealing the container body 21 with the rubber stopper 221. Furthermore, it is preferred that the container body 21 mounts a weight portion.

摘要翻译： 本发明的气泡制造容器20包括：具有开口部分的容器主体21; 以及设置在容器主体21的开口部分上的橡胶止动件221.橡胶止动件221构成为能够通过刺入注射针来取出容器主体21内部的气泡1。 优选的是，气泡制造容器20具有设置在橡胶塞221上的紧固部222，其具有开口并用橡胶塞221密封容器主体21.此外，优选的是，容器主体21安装重量部 。

公开(公告)号：EP3281692A1

公开(公告)日：2018-02-14

申请号：EP16776605.4

申请日：2016-04-07

申请人： Sonocore Inc.

发明人： TACHIBANA, Katsuro

IPC分类号： B01F3/04 ,  A61B8/06 ,  A61K49/00 ,  B01F11/00 ,  A61K9/10 ,  A61K9/127 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/42

CPC分类号： A61K9/5089 ,  A61B8/06 ,  A61J1/14 ,  A61K9/10 ,  A61K9/127 ,  A61K9/5052 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/42 ,  A61K49/00 ,  A61K49/0047 ,  A61K49/223 ,  A61N7/00 ,  A61N2007/0039 ,  B01F3/04 ,  B01F11/00 ,  B65B3/003 ,  B65D51/002

摘要： A method for manufacturing bubbles of the present invention includes: injecting an aqueous liquid 10 into a container 20 to a predetermined height; and vibrating the container at the number of revolution of equal to or higher than 5,000 rpm such that the aqueous liquid 10 repeatedly collides with an inner surface of the container 20. According to the manufacturing method, simply by vibrating the container 20 at a predetermined number of revolution, a large amount of bubbles 1 having a uniform size can be stably generated in the aqueous liquid 10. Furthermore, the vibrating the container 20 is preferably performed in a state where an internal pressure of the container 20 is higher than 1.0 atm.

摘要翻译： 本发明的制造气泡的方法包括：将含水液体10注入容器20至预定高度; 并以5,000rpm以上的转速使容器振动，使得水性液体10反复碰撞容器20的内表面。根据该制造方法，仅通过使容器20振动预定数量 能够在水性液体10中稳定地生成大量均匀尺寸的气泡1.此外，容器20的振动优选在容器20的内压高于1.0atm的状态下进行。

公开(公告)号：EP3096742A4

公开(公告)日：2017-09-27

申请号：EP15737194

申请日：2015-01-20

申请人： UNIV UTAH RES FOUND

发明人： WON YOUNG-WOOK ,  BULL DAVID A ,  PATEL AMIT N

IPC分类号： A61K9/127 ,  A61K35/12 ,  A61K35/28 ,  A61K47/64 ,  A61K47/69 ,  A61K49/00 ,  C12N5/00 ,  C12N5/0775 ,  G01N33/53

CPC分类号： A61K47/48276 ,  A61K35/28 ,  A61K47/48246 ,  A61K47/64 ,  A61K47/6425 ,  A61K47/6911 ,  A61K49/0041 ,  A61K49/0047 ,  A61K49/0084 ,  A61K2035/124 ,  C12N5/0006 ,  C12N5/0662 ,  C12N5/0663

公开(公告)号：EP2415783B1

公开(公告)日：2016-12-14

申请号：EP11183721.7

申请日：2007-10-16

申请人： Genelux Corporation

发明人： Frentzen, Alexa ,  Chen, Nanhai ,  Zhang, Qian ,  Yu, Yong ,  Szalay, Aladar

IPC分类号： C07K14/54 ,  C12N7/04 ,  C12N15/863 ,  A61K35/76 ,  A61K39/39 ,  A61K48/00

CPC分类号： C12N7/00 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/7068 ,  A61K33/24 ,  A61K35/76 ,  A61K38/1709 ,  A61K38/1793 ,  A61K38/20 ,  A61K38/204 ,  A61K38/36 ,  A61K38/484 ,  A61K39/12 ,  A61K39/285 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K48/0058 ,  A61K49/0008 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0097 ,  A61K49/14 ,  A61K49/1896 ,  A61K2039/523 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K14/47 ,  C07K14/54 ,  C07K14/5412 ,  C07K14/7155 ,  C07K16/22 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/60 ,  C07K2319/61 ,  C07K2319/74 ,  C12N15/86 ,  C12N2710/14171 ,  C12N2710/24121 ,  C12N2710/24122 ,  C12N2710/24132 ,  C12N2710/24141 ,  C12N2710/24143 ,  C12N2710/24162 ,  C12Q1/04 ,  G01N33/574 ,  G01N33/585

摘要： Modified or attenuated viruses and methods for preparing the modified viruses and modulating attenuation are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The viruses also can be used in diagnostic methods.

公开(公告)号：EP2097517B1

公开(公告)日：2014-06-04

申请号：EP07872632.0

申请日：2007-10-16

申请人： Genelux Corporation

发明人： FRENTZEN, Alexa ,  CHEN, Nanhai ,  ZHANG, Qian ,  YU, Yong, A. ,  SZALAY, Aladar, A.

IPC分类号： C12N7/04 ,  C12N15/863 ,  C07K14/07 ,  A61K35/76 ,  A61K39/285 ,  A61K48/00

CPC分类号： C12N7/00 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/7068 ,  A61K33/24 ,  A61K35/76 ,  A61K38/1709 ,  A61K38/1793 ,  A61K38/20 ,  A61K38/204 ,  A61K38/36 ,  A61K38/484 ,  A61K39/12 ,  A61K39/285 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K48/0058 ,  A61K49/0008 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0097 ,  A61K49/14 ,  A61K49/1896 ,  A61K2039/523 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K14/47 ,  C07K14/54 ,  C07K14/5412 ,  C07K14/7155 ,  C07K16/22 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/60 ,  C07K2319/61 ,  C07K2319/74 ,  C12N15/86 ,  C12N2710/14171 ,  C12N2710/24121 ,  C12N2710/24122 ,  C12N2710/24132 ,  C12N2710/24141 ,  C12N2710/24143 ,  C12N2710/24162 ,  C12Q1/04 ,  G01N33/574 ,  G01N33/585

摘要： Modified or attenuated viruses and methods for preparing the modified viruses and modulating attenuation are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The viruses also can be used in diagnostic methods.

公开(公告)号：EP2130837B1

公开(公告)日：2013-11-27

申请号：EP08738644.7

申请日：2008-03-06

申请人： National Center for Global Health and Medicine

发明人： ISHIZAKA, Yukihito ,  HASEGAWA, Masakatsu ,  NOHARA, Satoshi

IPC分类号： C07K7/08 ,  A61K41/00 ,  A61K47/48 ,  C07K7/06 ,  C07K9/00 ,  C07K14/16

CPC分类号： C07K14/005 ,  A61K47/64 ,  A61K49/0047 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/14 ,  A61K49/1863 ,  A61K49/1869 ,  B82Y5/00 ,  C07K7/08 ,  C07K2319/10 ,  C12N15/87 ,  C12N2740/16322

公开(公告)号：EP2229592A4

公开(公告)日：2013-10-16

申请号：EP08807592

申请日：2008-09-10

申请人： KIMBERLY CLARK CO

发明人： PLOWMAN THOMAS EDWARD ,  RAINONE MIKE ,  BAIRD DANIEL ,  HANTKE RICHARD ,  PHILLIPS ERICA M ,  PRESLEY TALBOT

IPC分类号： G01N33/569 ,  A61B5/00 ,  A61K49/00 ,  C12Q1/04 ,  G01N21/00 ,  G01N21/64 ,  G01N21/77 ,  G01N33/535

CPC分类号： G01N21/7703 ,  A61B5/0071 ,  A61K49/0013 ,  A61K49/0047 ,  A61K49/0097 ,  C12Q1/04 ,  G01N2021/7786 ,  G01N2021/7796

摘要： Disclosed herein are methods and devices for detection of bacterial HAI. Disclosed methods may be utilized for continuous in vivo monitoring of a potential bacterial infection site and may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of infection. Disclosed methods include utilization of recombinant bacteriophage to deliver to pathogenic bacteria a translatable genetic sequence encoding an optically detectable marker or an enzyme capable of producing an optically detectable marker. Upon detection of the optical signal produced by the marker, medical personnel may be alerted to the presence of pathogenic bacteria at the site of inquiry. Any bacterial causative agent of HAI may be detected according to disclosed methods.

公开(公告)号：EP2167956A1

公开(公告)日：2010-03-31

申请号：EP08741964.4

申请日：2008-05-02

申请人： Agency for Science, Technology and Research

发明人： ZHUO, Lang ,  HO, Gideon ,  KUMAR, Saravana

IPC分类号： G01N33/48

CPC分类号： A61K49/0008 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0393 ,  A61K49/0047 ,  C12N15/8509 ,  G01N2800/164

摘要： There is presently provided methods of monitoring retinopathy in a live transgenic, non-human animal, the methods comprising providing a live transgenic non-human animal having a retinal pathology or a pre-disposition for a retinal pathology, wherein a nucleic acid molecule encoding a fluorescent protein under control of a GFAP promoter is integrated into the genome of the transgenic non-human animal; and detecting in vivo in the retinal glia of the transgenic non-human anhnal fluorescence levels of the fluorescent protein.

摘要翻译： 目前提供了在活转基因非人动物中监测视网膜病的方法，所述方法包括提供具有视网膜病理学或视网膜病理学预处置的活转基因非人动物，其中编码 将GFAP启动子控制下的荧光蛋白整合到转基因非人动物的基因组中; 并在体内检测视网膜神经胶质中荧光蛋白的转基因非人荧光水平。