公开(公告)号：EP2049666A2

公开(公告)日：2009-04-22

申请号：EP07813317.0

申请日：2007-07-25

申请人： Sanofi-Aventis

发明人： AUGUST, Paul ,  HUANG, Waan Jeng ,  NATESAN, Sridaran ,  LIEBERMAN, Soyan

IPC分类号： C12N15/11 ,  A61K39/00 ,  A61K31/7105 ,  A61P35/00

CPC分类号： A61K31/7105 ,  A61K9/0019 ,  A61K48/00 ,  C12N9/0055 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2799/027 ,  C12Y110/02002

摘要： The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or other proteins of the respiratory complex III of mitochondria.

公开(公告)号：EP3501532A2

公开(公告)日：2019-06-26

申请号：EP18210159.2

申请日：2015-05-27

申请人： Stealth BioTherapeutics Corp

发明人： WILSON, D. Travis

IPC分类号： A61K38/07 ,  A61K31/353

CPC分类号： A61K38/10 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/13 ,  A61K38/1709 ,  A61K38/40 ,  A61K38/44 ,  A61K38/443 ,  A61K38/45 ,  A61K38/46 ,  A61K38/51 ,  A61K38/53 ,  A61K47/645 ,  C07K5/06078 ,  C07K5/06095 ,  C07K5/06156 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0817 ,  C07K5/0821 ,  C07K5/1016 ,  C07K5/1021 ,  C12Y101/01037 ,  C12Y101/01042 ,  C12Y102/04002 ,  C12Y103/05001 ,  C12Y106/05003 ,  C12Y109/03001 ,  C12Y110/02002 ,  C12Y203/03001 ,  C12Y306/03014 ,  C12Y402/01002 ,  C12Y402/01003 ,  C12Y602/01004 ,  C12Y604/01001

摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents ( e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2',6'-dimethyl-Tyr-D-Arg-Phe-Lys-NH 2 , Phe-D-Arg-Phe-Lys-NH 2 , or D-Arg-2',6'-Dmt-Lys-Phe-NH 2 .

公开(公告)号：EP3148565A4

公开(公告)日：2018-06-06

申请号：EP15799189

申请日：2015-05-27

申请人： STEALTH BIOTHERAPEUTICS CORP

发明人： WILSON D TRAVIS

IPC分类号： A61K38/07 ,  A61K31/353

CPC分类号： A61K38/10 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/13 ,  A61K38/1709 ,  A61K38/40 ,  A61K38/44 ,  A61K38/443 ,  A61K38/45 ,  A61K38/46 ,  A61K38/51 ,  A61K38/53 ,  A61K47/48315 ,  A61K47/645 ,  C07K5/06078 ,  C07K5/06095 ,  C07K5/06156 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0817 ,  C07K5/0821 ,  C07K5/1016 ,  C07K5/1021 ,  C12Y101/01037 ,  C12Y101/01042 ,  C12Y102/04002 ,  C12Y103/05001 ,  C12Y106/05003 ,  C12Y109/03001 ,  C12Y110/02002 ,  C12Y203/03001 ,  C12Y306/03014 ,  C12Y402/01002 ,  C12Y402/01003 ,  C12Y602/01004 ,  C12Y604/01001

摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2′,6′-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, or D-Arg-2′,6′-Dmt-Lys-Phe-NH2.

公开(公告)号：EP3148565A2

公开(公告)日：2017-04-05

申请号：EP15799189.4

申请日：2015-05-27

申请人： Stealth Biotherapeutics Corp

发明人： WILSON, D. Travis

IPC分类号： A61K38/07 ,  A61K31/353

CPC分类号： A61K38/10 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/13 ,  A61K38/1709 ,  A61K38/40 ,  A61K38/44 ,  A61K38/443 ,  A61K38/45 ,  A61K38/46 ,  A61K38/51 ,  A61K38/53 ,  A61K47/645 ,  C07K5/06078 ,  C07K5/06095 ,  C07K5/06156 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0817 ,  C07K5/0821 ,  C07K5/1016 ,  C07K5/1021 ,  C12Y101/01037 ,  C12Y101/01042 ,  C12Y102/04002 ,  C12Y103/05001 ,  C12Y106/05003 ,  C12Y109/03001 ,  C12Y110/02002 ,  C12Y203/03001 ,  C12Y306/03014 ,  C12Y402/01002 ,  C12Y402/01003 ,  C12Y602/01004 ,  C12Y604/01001

摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2′,6′-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, or D-Arg-2′,6′-Dmt-Lys-Phe-NH2.

摘要翻译： 本文公开了用于治疗和/或预防疾病或病症的方法和组合物，包括施用治疗性生物分子，和/或天然或人造出的衍生物，类似物或其药学上可接受的盐，单独或与一种或多种 活性剂（例如，芳族 - 阳离子肽）。 本技术提供了与治疗性生物分子连接的芳香族 - 阳离子肽相关的组合物及其用途。 在一些实施方案中，芳族阳离子肽包含2'，6'-二甲基-Tyr-D-Arg-Phe-Lys-NH 2，Phe-D-Arg-Phe-Lys-NH 2或D-Arg-2' 6'-DMT-赖氨酸的Phe-NH 2。