-
1.发明公开A HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES 审中-公开每股盈利RICH用于生产来自可再生资源化合物
公开(公告)号：EP3047030A4
公开(公告)日：2017-02-22
申请号：EP14846017
申请日：2014-09-17
申请人： ZYMOCHEM INC
发明人： CHOKHAWALA HARSHAL
CPC分类号： C12N15/52 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0016 , C12N9/1029 , C12N9/1096 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/2402 , C12N9/88 , C12N9/93 , C12P7/04 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/6409 , C12P13/001 , C12P13/005 , C12P17/08 , C12P17/10 , C12Y101/01001 , C12Y101/01002 , C12Y101/01035 , C12Y101/01078 , C12Y101/01268 , C12Y101/01269 , C12Y102/01003 , C12Y102/01005 , C12Y102/01022 , C12Y102/01024 , C12Y102/01026 , C12Y102/01048 , C12Y102/01063 , C12Y102/07005 , C12Y102/99006 , C12Y103/01044 , C12Y103/01045 , C12Y103/01086 , C12Y104/01 , C12Y203/01001 , C12Y203/01032 , C12Y203/01035 , C12Y203/01057 , C12Y206/01008 , C12Y206/01009 , C12Y206/01036 , C12Y206/01043 , C12Y206/01048 , C12Y206/01076 , C12Y206/01082 , C12Y207/01031 , C12Y207/01165 , C12Y208/03 , C12Y301/03 , C12Y301/03002 , C12Y301/03008 , C12Y301/03019 , C12Y301/0302 , C12Y302/01 , C12Y401/01001 , C12Y401/02 , C12Y401/02014 , C12Y401/0202 , C12Y401/02021 , C12Y401/03016 , C12Y401/03017 , C12Y402/01002 , C12Y402/01003 , C12Y402/01028 , C12Y402/0103 , C12Y402/01079 , C12Y402/0112 , C12Y602/01 , Y02E50/343
摘要： Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as 1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.
-
2.发明公开Gene for a heat resistant enzymes of the amino acid biosynthetic pathway derived from thermophilic Coryneform bacteria 有权嗜热菌嗜热菌Enzym desAminosäurebiosynthese-Systems and thermotolerantes Coryneformes Bakterium
公开(公告)号：EP1712632A2
公开(公告)日：2006-10-18
申请号：EP06009689.8
申请日：2000-10-04
申请人： Ajinomoto Co., Inc.
发明人： Hirano, Seiko Ajinomoto Co., Inc., Fermentation & , Nonaka, Gen Ajinomoto Co., Inc., Fermentation & , Matsuzaki, Yum Ajinomoto Co., Inc., Fermentation & , Akiyoshi, Naoki Ajinomoto Co. Inc., Fermentation & , Nakamura, Kanae 902, Stamford Court 8A , Kimura, Eiichiro Ajinomoto Co. Inc. Fermentation & , Osumi, Tsuyoshi Ajinomoto Co. Inc., Fermentation & , Matsui, Kazuhiko Ajinomoto Co. Inc. Fermentation & , Kawahara, Yoshio Ajinomoto Co. Inc. Fermentation & , Kurahashi, Osamu Ajinomoto Co. Inc. Fermentation & , Nakamatsu, Tsuyoshi Tokyo Denki Univ. Dept. of , Sugimoto, Shinichi Ajinomoto Co Inc.Fermentation &
IPC分类号： C12N15/60 , C12N15/54 , C12N15/53 , C12N15/31 , C12N15/56 , C12N9/88 , C12N9/12 , C12N9/04 , C07K14/34 , C12N9/26
CPC分类号： C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
摘要： A plurality of primer sets are designed based on a region where conservation at the amino acid level is observed among various microorganisms for known gene sequences corresponding to a gene coding for an enzyme of the L-amino acid biosynthetic pathway derived from Corynebacterium thermoaminogenes, preferably an enzyme that functions at a higher temperature compared with that of Corynebacterium glutamicum. PCR is performed by using the primers and chromosomal DNA of Corynebacterium thermoaminogenes as a template. The primers with which an amplification fragment has been obtained are used as primers for screening to select a clone containing a target DNA fragment from a plasmid library of chromosomal DNA of Corynebacterium thermoaminogenes.
摘要翻译： 基于对应于编码来源于热棒氨酸棒杆菌的L-氨基酸生物合成途径的酶的基因的已知基因序列的各种微生物在各种微生物中观察到氨基酸水平保护的区域来设计多个引物组，优选为 与谷氨酸棒杆菌相比在更高的温度下起作用的酶。 通过使用热源氨基酸棒杆菌的引物和染色体DNA作为模板进行PCR。 将获得了扩增片段的引物用作筛选引物，从嗜热氨基酸棒杆菌的染色体DNA的质粒文库中选择含有靶DNA片段的克隆。
-
3.发明公开THERMOPHILIC AMINO ACID BIOSYNTHESIS SYSTEM ENZYME GENE OF THERMOTOLERANT CORYNEFORM BACTERIUM 有权GEN FOR A嗜热酶氨基酸生物合成系统并和平THERMO棒状杆菌型细菌
公开(公告)号：EP1219712A4
公开(公告)日：2004-06-02
申请号：EP00964654
申请日：2000-10-04
申请人： AJINOMOTO KK
发明人： HIRANO SEIKO , NONAKA GEN , MATSUZAKI YUMI , AKIYOSHI NAOKI , NAKAMURA KANAE , KIMURA EIICHIRO , OSUMI TSUYOSHI , MATSUI KAZUHIKO , KAWAHARA YOSHIO , KURAHASHI OSAMU , NAKAMATSU TSUYOSHI , SUGIMOTO SHINICHI
IPC分类号： C07K14/34 , C12N9/02 , C12N9/04 , C12N9/12 , C12N9/26 , C12N9/88 , C12N15/31 , C12N15/53 , C12N15/54 , C12N15/56 , C12N15/60 , C12P13/04
CPC分类号： C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
摘要： PCR is effected by using chromosomal DNA of Corynebacterium thermoaminogenes as a template with plural primer pairs designed on the basis of domains conserved at the amino acid level among known gene sequences of various microorganisms corresponding to genes encoding L-amino acid biosynthesis system enzymes originating in Corynebacterium thermoaminogenes (preferably enzymes acting at higher temperatures than Corynebacterium glutamicum does). By using primers providing amplified fragments as screening primers, clones containing the target DNA fragments are selected from a Corynebacterium thermoaminogenes chromosomal DNA plasmid library.
-
4.发明授权Gene for a heat resistant enzyme of the amino acid biosynthetic pathway derived from thermophilic Coryneform bacteria 有权基因氨基酸生物合成系统嗜热的酶和热耐受性棒状杆菌型细菌
公开(公告)号：EP1712632B1
公开(公告)日：2009-12-02
申请号：EP06009689.8
申请日：2000-10-04
申请人： Ajinomoto Co., Inc.
发明人： Hirano, Seiko Ajinomoto Co., Inc., Fermentation & , Nonaka, Gen Ajinomoto Co., Inc., Fermentation & , Matsuzaki, Yumi Ajinomoto Co., Inc., Fermentation & , Akiyoshi, Naoki Ajinomoto Co. Inc., Fermentation & , Nakamura, Kanae c/o Ajinomoto Co., Inc., , Kimura, Eiichiro Ajinomoto Co. Inc. Fermentation & , Osumi, Tsuyoshi Ajinomoto Co. Inc., Fermentation & , Matsui, Kazuhiko Ajinomoto Co. Inc. Fermentation & , Kawahara, Yoshio Ajinomoto Co. Inc. Fermentation & , Kurahashi, Osamu Ajinomoto Co. Inc. Fermentation & , Nakamatsu, Tsuyoshi Tokyo Denki Univ. Dept. of , Sugimoto, Shinichi Ajinomoto Co Inc.Fermentation &
IPC分类号： C12N15/60 , C12N15/54 , C12N15/53 , C12N15/31 , C12N15/56 , C12N9/88 , C12N9/12 , C12N9/04 , C07K14/34 , C12N9/26
CPC分类号： C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
-
5.发明授权THERMOPHILIC AMINO ACID BIOSYNTHESIS SYSTEM ENZYME GENE OF THERMOTOLERANT CORYNEFORM BACTERIUM 有权GEN FOR A嗜热酶氨基酸生物合成系统并和平THERMO棒状杆菌型细菌
公开(公告)号：EP1219712B1
公开(公告)日：2008-05-21
申请号：EP00964654.8
申请日：2000-10-04
申请人： Ajinomoto Co., Inc.
发明人： HIRANO,Seiko Ajinomoto Co.Inc. Fermentat.&Bio.Lab. , NONAKA,Gen Ajinomoto Co.Inc. Fermentation&Bio.Lab. , MATSUZAKI,Yumi Ajinomoto Co.Inc. Fermenta.&Bio.Lab , AKIYOSHI,Naoki Ajinomoto Co.Inc. Fermenta.&Bio.Lab , NAKAMURA,Kanae 902 Stamford Court 8A , KIMURA,Eiichiro Ajinomoto Co.Inc. Ferment.&Bio.Lab , OSUMI,Tsuyoshi Ajinomoto Co.Inc. Fermenta.&Bio.Lab , MATSUI,Kazuhiko Ajinomoto Co.Inc. Fermenta.Bio.Lab , KAWAHARA,Yoshio Ajinomoto Co.Inc. Fermenta.Bio.Lab , KURAHASHI,Osamu Ajinomoto Co.Inc. Fermenta.Bio.Lab , NAKAMATSU,Tsuyoshi Ajinomoto Co.Inc. Ferme.Bio.Lab , SUGIMOTO,Shinichi Ajinomoto Co.Inc. Fermen.Bio.Lab
IPC分类号： C12N15/60 , C12N15/54 , C12N15/53 , C12N15/31 , C12N15/56 , C12N9/88 , C12N9/12 , C12N9/04 , C07K14/34 , C12N9/26 , C12P13/04
CPC分类号： C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
-
6.发明公开THERMOPHILIC AMINO ACID BIOSYNTHESIS SYSTEM ENZYME GENE OF THERMOTOLERANT CORYNEFORM BACTERIUM 有权GENFÜREIN热水器ENZYM DESAMINOSÄUREBIOSYNTHESE-SYSTEMS UND THERMOLOLERANTES CORYNEFORMES BAKTERIUM
公开(公告)号：EP1219712A1
公开(公告)日：2002-07-03
申请号：EP00964654.8
申请日：2000-10-04
申请人： Ajinomoto Co., Inc.
发明人： HIRANO,Seiko Ajinomoto Co.Inc. Fermentat.&Bio.Lab. , NONAKA,Gen Ajinomoto Co.Inc. Fermentation&Bio.Lab. , MATSUZAKI,Yumi Ajinomoto Co.Inc. Fermenta.&Bio.Lab , AKIYOSHI,Naoki Ajinomoto Co.Inc. Fermenta.&Bio.Lab , NAKAMURA,Kanae 902 Stamford Court 8A , KIMURA,Eiichiro Ajinomoto Co.Inc. Ferment.&Bio.Lab , OSUMI,Tsuyoshi Ajinomoto Co.Inc. Fermenta.&Bio.Lab , MATSUI,Kazuhiko Ajinomoto Co.Inc. Fermenta.Bio.Lab , KAWAHARA,Yoshio Ajinomoto Co.Inc. Fermenta.Bio.Lab , KURAHASHI,Osamu Ajinomoto Co.Inc. Fermenta.Bio.Lab , NAKAMATSU,Tsuyoshi Ajinomoto Co.Inc. Ferme.Bio.Lab , SUGIMOTO,Shinichi Ajinomoto Co.Inc. Fermen.Bio.Lab
IPC分类号： C12N15/60 , C12N15/54 , C12N15/53 , C12N15/31 , C12N15/56 , C12N9/88 , C12N9/12 , C12N9/04 , C07K14/34 , C12N9/26 , C12P13/04
CPC分类号： C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
摘要： A plurality of primer sets are designed based on a region where conservation at the amino acid level is observed among various microorganisms for known gene sequences corresponding to a gene coding for an enzyme of the L-amino acid biosynthetic pathway derived from Corynebacterium thermoaminogenes, preferably an enzyme that functions at a higher temperature compared with that of Corynebacterium glutamicum. PCR is performed by using the primers and chromosomal DNA of Corynebacterium thermoaminogenes as a template. The primers with which an amplification fragment has been obtained are used as primers for screening to select a clone containing a target DNA fragment from a plasmid library of chromosomal DNA of Corynebacterium thermoaminogenes.
摘要翻译： 基于对应于编码来源于热棒氨酸棒杆菌的L-氨基酸生物合成途径的酶的基因的已知基因序列的各种微生物在各种微生物中观察到氨基酸水平保护的区域来设计多个引物组，优选为 与谷氨酸棒杆菌相比在更高的温度下起作用的酶。 通过使用热源氨基酸棒杆菌的引物和染色体DNA作为模板进行PCR。 将获得了扩增片段的引物用作筛选引物，从嗜热氨基酸棒杆菌的染色体DNA的质粒文库中选择含有靶DNA片段的克隆。
-
7.发明公开RECOMBINANT ENZYME SYSTEMS FOR PRODUCTION OF ITACONATE IN CELLS 有权ZENEN的REKOMBINANTE ENZYMSYSTEME ZUR HERSTELLUNG VONITACONSÄURE
公开(公告)号：EP3018141A1
公开(公告)日：2016-05-11
申请号：EP15159700.2
申请日：2015-03-18
发明人： Lee, Li-Feng , Chang, Pei-Ching , Chu, Hsiang-Yuan
IPC分类号： C07K14/435
CPC分类号： C12P7/44 , C07K2319/00 , C12N9/88 , C12Y401/01006 , C12Y402/01003 , Y02P20/52
摘要： Described herein is a fusion polypeptide containing an aconitase and a cis-aconitate decarboxylase. Also described are a genetically modified cell expressing the fusion polypeptide and a method of using the cell to produce itaconate.
摘要翻译： 本文描述的是含有乌头碱酶和顺式乌头酸脱羧酶的融合多肽。 还描述了表达融合多肽的遗传修饰细胞和使用该细胞产生衣康酸酯的方法。
-
8.发明公开L-LYSINE GENERATION METHOD BY FERMENTING BACTERIA HAVING MODIFIED ACONITASE GENE AND/OR REGULATORY ELEMENT 有权VERFAHREN ZUR ERZEUGUNG VON L-LYSIN DURCH发酵巴斯德氏麻醉剂改性剂
公开(公告)号：EP2824186A4
公开(公告)日：2015-11-25
申请号：EP14748825
申请日：2014-01-07
发明人： MA JIYIN , WEN TINGYI , CHEN JINLONG , LIANG YONG , LIU SHUWEN , WEI AIYING , YANG LIPENG , REN RUI , MENG GANG , ZHAO CHUNGUANG , ZHANG YUN , SHANG XIULING , GUO XIAOWEI
CPC分类号： C12P13/08 , C12N9/88 , C12N15/70 , C12Y402/01003
摘要： Provided is a method of producing L-lysine by fermentation, which comprises the steps of modifying an aconitase gene and/or regulatory element thereof in a chromosome of a bacterium so that the activity and/or the expression amount of the aconitase of the bacterium are reduced but not eliminated; and producing L-lysine by the fermentation of the modified bacterium. In addition, also provided are methods and uses derived from the method as well as bacteria used in these methods and uses.
摘要翻译： 提供通过发酵生产L-赖氨酸的方法，其包括在细菌染色体中修饰乌头酸酶基因和/或调节元件的步骤，使得细菌的乌头酸酶的活性和/或表达量为 减少但不消除; 并通过改良细菌的发酵生产L-赖氨酸。 此外，还提供了从该方法得到的方法和用途以及这些方法和用途中使用的细菌。
-
9.发明公开Gene for a heat resistant enzyme of amino acid biosynthetic pathway derived from thermophilic Coryneform bacteria 有权一般来说，耐药性Enzym desAminosäuresynthesewegesaus thermophilen Coryneformen Bakterien
公开(公告)号：EP1710313A1
公开(公告)日：2006-10-11
申请号：EP06009690.6
申请日：2000-10-04
申请人： Ajinomoto Co., Inc.
发明人： Hirano, Seiko Ajinomoto Co., Inc., Fermentation & , Nonaka, Gen Ajinomoto Co., Inc., Fermentation & , Matsuzaki, Yum Ajinomoto Co., Inc., Fermentation & , Akiyoshi, Naoki Ajinomoto Co. Inc., Fermentation & , Nakamura, Kanae 902, Stamford Court 8A , Kimura, Eiichiro Ajinomoto Co. Inc. Fermentation & , Osumi, Tsuyoshi Ajinomoto Co. Inc., Fermentation & , Matsui, Kazuhiko Ajinomoto Co. Inc. Fermentation & , Kawahara, Yoshio Ajinomoto Co. Inc. Fermentation & , Kurahashi, Osamu Ajinomoto Co. Inc. Fermentation & , Nakamatsu, Tsuyoshi Tokyo Denki Univ. Dept. of , Sugimoto, Shinichi Ajinomoto Co Inc.Fermentation &
IPC分类号： C12N15/60 , C12N15/54 , C12N15/53 , C12N15/31 , C12N15/56 , C12N9/88 , C12N9/12 , C12N9/04 , C07K14/34 , C12N9/26
CPC分类号： C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
摘要： A plurality of primer sets are designed based on a region where conservation at the amino acid level is observed among various microorganisms for known gene sequences corresponding to a gene coding for an enzyme of the L-amino acid biosynthetic pathway derived from Corynebacterium thermoaminogenes, preferably an enzyme that functions at a higher temperature compared with that of Corynebacterium glutamicum. PCR is performed by using the primers and chromosomal DNA of Corynebacterium thermoaminogenes as a template. The primers with which an amplification fragment has been obtained are used as primers for screening to select a clone containing a target DNA fragment from a plasmid library of chromosomal DNA of Corynebacterium thermoaminogenes.
摘要翻译： 基于对应于编码来源于热棒氨酸棒杆菌的L-氨基酸生物合成途径的酶的基因的已知基因序列的各种微生物在各种微生物中观察到氨基酸水平保护的区域来设计多个引物组，优选为 与谷氨酸棒杆菌相比在更高的温度下起作用的酶。 通过使用热源氨基酸棒杆菌的引物和染色体DNA作为模板进行PCR。 将获得了扩增片段的引物用作筛选引物，从嗜热氨基酸棒杆菌的染色体DNA的质粒文库中选择含有靶DNA片段的克隆。
-
10.发明公开
公开(公告)号：EP3501532A2
公开(公告)日：2019-06-26
申请号：EP18210159.2
申请日：2015-05-27
发明人： WILSON, D. Travis
IPC分类号： A61K38/07 , A61K31/353
CPC分类号： A61K38/10 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/13 , A61K38/1709 , A61K38/40 , A61K38/44 , A61K38/443 , A61K38/45 , A61K38/46 , A61K38/51 , A61K38/53 , A61K47/645 , C07K5/06078 , C07K5/06095 , C07K5/06156 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0821 , C07K5/1016 , C07K5/1021 , C12Y101/01037 , C12Y101/01042 , C12Y102/04002 , C12Y103/05001 , C12Y106/05003 , C12Y109/03001 , C12Y110/02002 , C12Y203/03001 , C12Y306/03014 , C12Y402/01002 , C12Y402/01003 , C12Y602/01004 , C12Y604/01001
摘要： Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents ( e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2',6'-dimethyl-Tyr-D-Arg-Phe-Lys-NH 2 , Phe-D-Arg-Phe-Lys-NH 2 , or D-Arg-2',6'-Dmt-Lys-Phe-NH 2 .
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.013 秒)
