-
1.发明公开TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) INJURY 审中-公开白兰莪VERLETZUNGEN DES ZENTRALEN NERVENSYSTEMS（ZNS）
公开(公告)号：EP2900256A1
公开(公告)日：2015-08-05
申请号：EP13771750.0
申请日：2013-09-25
CPC分类号： C07K16/18 , A61K38/465 , C07K2317/76 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12Y301/06012
摘要： The invention features compositions for use in increasing neuron or neurite growth, including for the treatment of Central Nervous System (CNS) injury, such as human arylsulfatase B.
摘要翻译： 本发明的特征在于用于增加神经元或神经突生长的组合物，包括治疗中枢神经系统（CNS）损伤，例如人类芳基硫酸酯酶B.
-
2.发明公开Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme 有权前体N-乙酰-4-硫酸酯酶，使用这种酶的生产和纯化这种酶和方法进行治疗的方法
公开(公告)号：EP2327414A1
公开(公告)日：2011-06-01
申请号：EP10011421.4
申请日：2003-11-07
发明人： Qin, Minmin , Henstrand, John, M. , Zecherle, Gary, N. , Wendt, Dan, J. , Chan, Wai-Pan , Chen, Lin , Fitzpatrick, Paul, A. , Starr, Christopher, M. , Swiedler, Stuart
CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012
摘要： The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N -acetylgalactosamirie-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N -acetylgalactosamine-4-sulfatase including MPS Vl and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
摘要翻译： 本发明提供一种高度纯化的重组人前体N-乙酰半乳糖-4-硫酸酯酶和生物学活性突变体，片段和类似物以及药物配方和灰包括高度纯化的重组人前体Ñ-acetylgalactosamirie -4-硫酸酯酶。 因此，本发明提供了用于治疗由人N- -acetylgalactosamine -4-硫酸酯酶包含MPS VI和用于生产和纯化重组前体酶的高度纯化形式的方法的缺陷引起的全部或部分的疾病的方法。
-
3.发明公开PRECURSOR N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME 有权PRE-N-乙酰基-4-硫酸酯酶，治疗用于生产清洁此酶的方法使用该酶和方法
公开(公告)号：EP1565209A4
公开(公告)日：2008-01-02
申请号：EP03783223
申请日：2003-11-07
申请人： BIOMARIN PHARM INC
发明人： QIN MINMIN , HENSTRAND JOHN M , ZECHERLE GARY N , WENDT DAN J , CHAN WAI-PAN , CHEN LIN , FITZPATRICK PAUL A , STARR CHRISTOPHER M , SWIEDLER STUART
CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012
-
4.发明授权Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme 有权前体N-乙酰-4-硫酸酯酶，使用这种酶的生产和纯化这种酶和方法进行治疗的方法
公开(公告)号：EP2327414B1
公开(公告)日：2015-01-07
申请号：EP10011421.4
申请日：2003-11-07
发明人： Qin, Minmin , Henstrand, John M. , Zecherle, Gary N. , Wendt, Dan J. , Chan, Wai-Pan , Chen, Lin , Fitzpatrick, Paul A. , Starr, Christopher M. , Swiedler, Stuart
CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012
-
5.发明授权PRECURSOR N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME 有权PRE-N-乙酰基-4-硫酸酯酶，治疗用于生产清洁此酶的方法使用该酶和方法
公开(公告)号：EP1565209B1
公开(公告)日：2013-11-06
申请号：EP03783223.5
申请日：2003-11-07
发明人： QIN, Minmin , HENSTRAND, John, M. , ZECHERLE, Gary, N. , WENDT, Dan, J. , CHAN, Wai-Pan , CHEN, Lin , FITZPATRICK, Paul, A. , STARR, Christopher, M. , SWIEDLER, Stuart
CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012
-
6.发明公开PRECURSOR N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME 有权PRE-N-乙酰基-4-硫酸酯酶，治疗用于生产清洁此酶的方法使用该酶和方法
公开(公告)号：EP1565209A2
公开(公告)日：2005-08-24
申请号：EP03783223.5
申请日：2003-11-07
发明人： QIN, Minmin , HENSTRAND, John, M. , ZECHERLE, Gary, N. , WENDT, Dan, J. , CHAN, Wai-Pan , CHEN, Lin , FITZPATRICK, Paul, A. , STARR, Christopher, M. , SWEIDLER, Stuart
CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012
摘要： The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.017 秒)
