专利检索 ap:("BioMarin Pharmaceutical Inc.") AND inv:"STARR, Christopher, M." 第 1 页

1.

发明授权
PRECURSOR N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME 有权
标题翻译： PRE-N-乙酰基-4-硫酸酯酶，治疗用于生产清洁此酶的方法使用该酶和方法

公开(公告)号：EP1565209B1

公开(公告)日：2013-11-06

申请号：EP03783223.5

申请日：2003-11-07

申请人： BioMarin Pharmaceutical Inc.

发明人： QIN, Minmin , HENSTRAND, John, M. , ZECHERLE, Gary, N. , WENDT, Dan, J. , CHAN, Wai-Pan , CHEN, Lin , FITZPATRICK, Paul, A. , STARR, Christopher, M. , SWIEDLER, Stuart

IPC分类号： A61K38/46 , C12N9/14 , C12N1/02 , C12N15/00 , C07H21/04

CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012

2.

发明公开
PRECURSOR N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME 有权
标题翻译： PRE-N-乙酰基-4-硫酸酯酶，治疗用于生产清洁此酶的方法使用该酶和方法

公开(公告)号：EP1565209A2

公开(公告)日：2005-08-24

申请号：EP03783223.5

申请日：2003-11-07

申请人： BioMarin Pharmaceutical Inc.

发明人： QIN, Minmin , HENSTRAND, John, M. , ZECHERLE, Gary, N. , WENDT, Dan, J. , CHAN, Wai-Pan , CHEN, Lin , FITZPATRICK, Paul, A. , STARR, Christopher, M. , SWEIDLER, Stuart

IPC分类号： A61K38/46 , C12N9/14 , C12N1/02 , C12N15/00 , C07H21/04

CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012

摘要： The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.

3.

发明公开
USE OF P97 AS AN ENZYME DELIVERY SYSTEM FOR THE DELIVERY OF THERAPEUTIC LYSOSOMAL ENZYMES 有权
标题翻译： P97作为酶系统中使用的治疗性溶酶体酶的供应配送

公开(公告)号：EP1463512A2

公开(公告)日：2004-10-06

申请号：EP03717870.4

申请日：2003-01-10

申请人： BioMarin Pharmaceutical, Inc.

发明人： STARR, Christopher, M. , ZANKEL, Todd

IPC分类号： A61K31/70 , A61K38/46 , A61K39/395 , C07K1/00 , C12P21/06 , C12P21/04 , G01N33/53

CPC分类号： A61K47/64 , A61K38/465 , A61K38/47 , C12Y302/01076 , G01N33/5008 , G01N33/5035 , G01N33/5058 , G01N33/566 , A61K2300/00

摘要： The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.