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1.发明公开COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE AND METHODS OF TREATING CANCER USING COMPOSITIONS THEREOF 有权用于癌症治疗组合物组合物的原核苯丙氨酸解氨及其方法
公开(公告)号：EP2175875A2
公开(公告)日：2010-04-21
申请号：EP08795357.6
申请日：2008-08-15
发明人： VELLARD, Michel, C. , FITZPATRICK, Paul, A. , KAKKIS, Emil, D. , WENDT, Daniel, J. , MUTHALIF, Mubarack , BELL, Sean, M. , OKHAMAFE, Augustus, O.
CPC分类号： A61K38/164 , A61K38/51
摘要： The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild- type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer.
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2.发明授权PRECURSOR N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME 有权PRE-N-乙酰基-4-硫酸酯酶，治疗用于生产清洁此酶的方法使用该酶和方法
公开(公告)号：EP1565209B1
公开(公告)日：2013-11-06
申请号：EP03783223.5
申请日：2003-11-07
发明人： QIN, Minmin , HENSTRAND, John, M. , ZECHERLE, Gary, N. , WENDT, Dan, J. , CHAN, Wai-Pan , CHEN, Lin , FITZPATRICK, Paul, A. , STARR, Christopher, M. , SWIEDLER, Stuart
CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012
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3.发明公开PRECURSOR N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME 有权PRE-N-乙酰基-4-硫酸酯酶，治疗用于生产清洁此酶的方法使用该酶和方法
公开(公告)号：EP1565209A2
公开(公告)日：2005-08-24
申请号：EP03783223.5
申请日：2003-11-07
发明人： QIN, Minmin , HENSTRAND, John, M. , ZECHERLE, Gary, N. , WENDT, Dan, J. , CHAN, Wai-Pan , CHEN, Lin , FITZPATRICK, Paul, A. , STARR, Christopher, M. , SWEIDLER, Stuart
CPC分类号： B01D15/3804 , A61K38/00 , B01D15/327 , B01D15/3828 , C12N9/16 , C12Y301/06012
摘要： The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
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4.发明授权COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE VARIANTS AND METHODS OF USING COMPOSITIONS THEREOF 有权从原核苯丙氨酸解氨，变异和方法的组合物用于其使用组合物
公开(公告)号：EP2531209B1
公开(公告)日：2016-04-20
申请号：EP11740323.8
申请日：2011-02-03
发明人： OKHAMAFE, Augustus, O. , BELL, Sean, M. , ZECHERLE, G., Nick , ANTONSEN, Kris , ZHANG, Yanhong , LY, Kieu, Y , FITZPATRICK, Paul, A. , KAKKIS, Emil, D. , VELLARD, Michel, Claude , WENDT, Daniel, J. , MUTHALIF, Mubarack
CPC分类号： C12N9/88 , A61K9/0019 , A61K38/51 , A61K47/60 , C12Y403/01024
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5.发明公开
公开(公告)号：EP1814984A2
公开(公告)日：2007-08-08
申请号：EP05816095.3
申请日：2005-09-19
发明人： GAMEZ, Alejandra , WANG, Lin , KIM, Woomi , STRAUB, Mary , PATCH, Marianne, G. , KAKKIS, Emil , OPPENHEIMER, Dan , FITZPATRICK, Paul, A. , HEFT, Robert , STEVENS, Raymond, C.
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C07K2299/00 , Y02A90/26
摘要： The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.
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6.发明授权COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE AND METHODS OF TREATING CANCER USING COMPOSITIONS THEREOF 有权用于癌症治疗组合物组合物的原核苯丙氨酸解氨及其方法
公开(公告)号：EP2175875B1
公开(公告)日：2016-10-05
申请号：EP08795357.6
申请日：2008-08-15
发明人： VELLARD, Michel, C. , FITZPATRICK, Paul, A. , KAKKIS, Emil D. , WENDT, Daniel, J. , MUTHALIF, Mubarack , BELL, Sean, M. , OKHAMAFE, Augustus, O.
CPC分类号： A61K38/164 , A61K38/51
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7.发明授权COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE AND METHODS OF USING SAID COMPOSITIONS 有权组成原核生物苯丙氨酸氨裂解酶，且使用该组合方法的
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8.发明公开COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE VARIANTS AND METHODS OF USING COMPOSITIONS THEREOF 有权从原核苯丙氨酸解氨，变异和方法的组合物用于其使用组合物
公开(公告)号：EP2531209A2
公开(公告)日：2012-12-12
申请号：EP11740323.8
申请日：2011-02-03
发明人： OKHAMAFE, Augustus, O. , BELL, Sean, M. , ZECHERLE, G., Nick , ANTONSEN, Kris , ZHANG, Yanhong , LY, Kieu, Y , FITZPATRICK, Paul, A. , KAKKIS, Emil, D. , VELLARD, Michel, Claude , WENDT, Daniel, J. , MUTHALIF, Mubarack
IPC分类号： A61K38/51
CPC分类号： C12N9/88 , A61K9/0019 , A61K38/51 , A61K47/60 , C12Y403/01024
摘要： Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.
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9.发明公开COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE AND METHODS OF USING SAID COMPOSITIONS 有权组成原核生物苯丙氨酸氨裂解酶，且使用该组合方法的
公开(公告)号：EP2152868A1
公开(公告)日：2010-02-17
申请号：EP08754717.0
申请日：2008-05-23
IPC分类号： C12N9/88
摘要： The present invention is directed to phenylalanine ammonia-lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention thus provides compositions of bacterial PAL and biologically active fragments, mutants, variants and analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic and industrial purposes.
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