公开(公告)号：EP3262406A1

公开(公告)日：2018-01-03

申请号：EP16756326.1

申请日：2016-02-25

申请人： Waters Technologies Corporation

发明人： FOGWILL, Michael, O. ,  MICHIENZI, Joseph, D. ,  GILAR, Martin ,  TARAFDER, Abhijit

IPC分类号： G01N30/00 ,  G01N30/02 ,  G01N30/26 ,  G01N30/30

CPC分类号： G01N30/30 ,  B01D15/161 ,  G01N30/34 ,  G01N30/461 ,  G01N30/8637 ,  G01N2030/027 ,  G01N2030/3015 ,  G01N2030/3076

摘要： Methods for focusing analyte peaks in liquid chromatography using a spatial temperature gradient are provided. Also provided are methods for focusing analyte peaks and improving resolution using a trap column upstream of a separation column. Further, methods are provided in which the trap column placed upstream of the separation column is packed with a temperature-sensitive polymer/copolymer, and a spatial temperature gradient is applied along the trap column for obtaining improved retentivity by trap column stationary phase, and overall improved resolution of analyte peaks.

公开(公告)号：EP2356441A1

公开(公告)日：2011-08-17

申请号：EP09752355.9

申请日：2009-11-12

申请人： Proxeon Biosystems A/S

发明人： VORM, Ole

IPC分类号： G01N30/08 ,  G01N30/30

CPC分类号： G01N30/08 ,  G01N30/30 ,  G01N2030/085 ,  G01N2030/122 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3076

摘要： A method is provided for thermally focusing an analyte on a pre-column for liquid chromatography, comprising the steps of enriching the sample on said pre-column at a temperature lower than the operating temperature of a separation column, injecting the sample onto the separation column by heating the pre-column to a temperature higher than the temperature of the separation column and eluting the analyte from the separation column. Optionally, the sample may be subjected to a temperature gradient on the separation column or the separation column may be heated to remove non-eluted sample after the separation is completed.

公开(公告)号：EP1563291A2

公开(公告)日：2005-08-17

申请号：EP03796344.4

申请日：2003-09-26

申请人： Honeywell International, Inc.

发明人： BONNE, Ulrich

IPC分类号： G01N30/12 ,  G01N30/46

CPC分类号： G01N30/466 ,  G01N30/12 ,  G01N30/30 ,  G01N30/468 ,  G01N30/6095 ,  G01N30/88 ,  G01N33/0011 ,  G01N2030/3076 ,  G01N2030/3015

摘要： A micro fluid analyzer (500, 600, 610, 620) having a concentrator (523, 623) and two separators (524, 525, 624, 625, 651, 654). The analyzer may have one or two pumps(521, 522, 640, 621, 622). The analyzer (500) may have a hyper pre-concentrator (526) having a number of channels (527). There are numerous detectors (531, 532, 533, 534, 631, 632, 633, 634) positioned along the flow path of the analyzer. Also, one or more orifices (541, 542, 644, 645, 647, 648, 653, 656) and micro valves (641, 541, 661) may be positioned in the flow path. The concentrator (523, 623) may have an array of heater elements (20, 22, 24, 26) that provide a heat pulse that moves along the fluid path to provide an increasing concentration of heat in a fluid. The analyzer may be configured as a multiple fluid or gas chromatograph.

公开(公告)号：EP0661537A3

公开(公告)日：1995-08-30

申请号：EP94306176.2

申请日：1994-08-22

申请人： CHROMATOFAST

发明人： Klemp, Mark Allen ,  Peters, Anita Jo

IPC分类号： G01N30/12 ,  G01N30/40

CPC分类号： G01N30/12 ,  G01N30/40 ,  G01N2030/025 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/128 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/623 ,  G01N2030/3076 ,  G01N2030/3023

摘要： A gas chromatograph system (10) including a cold trap (12) having two portions (12a and 12b), a capillary tube (14) and a porous layer open tubular (PLOT) column (15), for substantially simultaneously trapping lower and higher boiling point gasses. The capillary tube (14) enables cold trapping of lower boiling point gasses while the PLOT column (15) enables cold trapping of higher boiling point gasses. The capillary tube interconnects at one end to an analytical column (20) and a sample gas source (26) and interconnects at its other end to a first end of the PLOT column (15). The other end of the PLOT column interconnects to a carrier gas source and a vacuum source. The capillary tube and PLOT column are both positioned within a temperature controlled environment of the cold trap. During the collection mode, the temperature control means maintains a relatively low temperature to condense the sample components. During injection of the sample from the cold trap to the analytical column, the temperature control means maintains a relatively high temperature to vaporize the sample components.

公开(公告)号：EP0661537A2

公开(公告)日：1995-07-05

申请号：EP94306176.2

申请日：1994-08-22

申请人： CHROMATOFAST

发明人： Klemp, Mark Allen ,  Peters, Anita Jo

IPC分类号： G01N30/12 ,  G01N30/40

CPC分类号： G01N30/12 ,  G01N30/40 ,  G01N2030/025 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/128 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/623 ,  G01N2030/3076 ,  G01N2030/3023

摘要： A gas chromatograph system (10) including a cold trap (12) having two portions (12a and 12b), a capillary tube (14) and a porous layer open tubular (PLOT) column (15), for substantially simultaneously trapping lower and higher boiling point gasses. The capillary tube (14) enables cold trapping of lower boiling point gasses while the PLOT column (15) enables cold trapping of higher boiling point gasses. The capillary tube interconnects at one end to an analytical column (20) and a sample gas source (26) and interconnects at its other end to a first end of the PLOT column (15). The other end of the PLOT column interconnects to a carrier gas source and a vacuum source. The capillary tube and PLOT column are both positioned within a temperature controlled environment of the cold trap. During the collection mode, the temperature control means maintains a relatively low temperature to condense the sample components. During injection of the sample from the cold trap to the analytical column, the temperature control means maintains a relatively high temperature to vaporize the sample components.

摘要翻译： 一种气相色谱系统（10），包括具有两部分的冷阱，毛细管和多孔层开放管（PLOT）柱，用于基本上同时捕获较低沸点和较高沸点的气体。 毛细管能够冷藏低沸点气体，而PLOT柱可以冷却高沸点气体。 毛细管一端连接到分析柱和样品气体源，并在其另一端互连到PLOT柱的第一端。 PLOT列的另一端与载气源和真空源相互连接。 毛细管和PLOT柱均位于冷阱的温度控制环境内。 在收集模式期间，温度控制装置保持相对较低的温度以冷凝样品组分。 在将样品从冷阱注入分析柱期间，温度控制装置保持相对高的温度以蒸发样品组分。

公开(公告)号：EP0590932A2

公开(公告)日：1994-04-06

申请号：EP93307673.9

申请日：1993-09-28

申请人： Peters, Anita Jo ,  Sacks, Richard Douglas

发明人： Peters, Anita Jo ,  Sacks, Richard Douglas

IPC分类号： G01N30/16 ,  G01N30/30 ,  G01N30/12

CPC分类号： G01N30/12 ,  G01N30/40 ,  G01N2030/025 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/128 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/623 ,  G01N2030/3076 ,  G01N2030/3023

摘要： A gas chromatography system in which prefocusing of a sample analyte is provided through the use of an adsorbent coated porous layer open tubular trap tube. Through the use of an adsorbent coated collection device low boiling point components can be successfully trapped for preconcentration and injection at temperatures well above that necessary when employing conventional cryo-focusing.

摘要翻译： 通过使用吸附剂涂覆的多孔层开放式管状捕集管提供样品分析物的预聚焦的气相色谱系统。 通过使用吸附剂涂覆的收集装置，当使用常规的低温聚焦时，低沸点成分可以成功地被捕获以用于预浓缩和注入。

公开(公告)号：EP3341721A1

公开(公告)日：2018-07-04

申请号：EP16758071.1

申请日：2016-08-24

申请人： Dow Global Technologies LLC

发明人： CONG, Rongjuan ,  PARROT, Albert ,  HOLLIS, Cherry ,  CHEATHAM, Charles Michael

IPC分类号： G01N30/54 ,  G01N30/88

CPC分类号： G01N30/54 ,  B01D9/0013 ,  B01D15/10 ,  G01N30/30 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/3076 ,  G01N2030/885

摘要： A temperature gradient chromatography, and apparatus for the same, said method comprising the following: a) dissolving a composition comprising at least one polymer in at least one solvent, to form a polymer solution; b) injecting at least a portion of the polymer solution onto a support material and wherein the support material has a CI from 0.70 to 1.50; c) cooling the support material at a rate greater than, or equal to, 0.2° C./min; d) increasing the temperature of the support material to elute at least some of the polymer; e) generating the chromatogram.

公开(公告)号：EP2516033B1

公开(公告)日：2017-07-05

申请号：EP10798685.3

申请日：2010-12-21

申请人： Dow Global Technologies LLC

发明人： WINNIFORD, William ,  CONG, Rongjuan ,  STOKICH, Theodore ,  PELL, Randy ,  MILLER, Matthew ,  ROY, Abhishek ,  VAN DAMME, Freddy ,  DEGROOT, Alexander ,  LYONS, John ,  MEUNIER, David

IPC分类号： B01D15/16 ,  G01N30/30 ,  G01N30/34

CPC分类号： B01D15/161 ,  B01D15/166 ,  B01D15/1878 ,  B01J20/24 ,  B01J2220/4825 ,  G01N30/34 ,  G01N2030/3076 ,  G01N2030/885

公开(公告)号：EP2541244B1

公开(公告)日：2017-05-03

申请号：EP12177537

申请日：2007-08-20

申请人： PERKINELMER INC

发明人： TIPLER ANDREW ,  BOTELHO JAMES ,  DALMIA AVINASH ,  RAFA MICHAEL ,  VANDERHOEF JOHN ,  SCHALLIS PAUL ,  GREEN NEAL ,  SCOTT DAVID J ,  MCCAFFREY JOHN ,  ST CYR PAUL L ,  MCCORKLE JOEL E ,  COPPOLA GUISEPPE

IPC分类号： G01N30/30

CPC分类号： G01N30/30 ,  G01N2030/3076 ,  G01N2030/3084

公开(公告)号：EP2302372A1

公开(公告)日：2011-03-30

申请号：EP09170744.8

申请日：2009-09-18

申请人： Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH

发明人： Zimmermann, Ralf ,  Bozorgzad, Mohammad Reza Saraji ,  Eschner, Markus, Simon ,  Gröger, Thomas maximilian

IPC分类号： G01N30/12 ,  G01N30/72 ,  G01N30/46

CPC分类号： G01N30/12 ,  G01N30/462 ,  G01N30/463 ,  G01N30/7206 ,  G01N2030/122 ,  G01N2030/3046 ,  G01N2030/3076 ,  H01J27/24 ,  H01J49/162

摘要： The present invention relates to a method for repetitive chemical analysis of a gas flow, wherein said gas flow consists of a carrier gas and gaseous chemical compounds, comprising the following method steps: feeding said gas flow to a gas chromatographic separation column (42) by means of a feeding device (3); collecting at least a part of said gaseous chemical compounds for a defined time period by means of a thermally based collecting device (41) which is coupled to said gas chromatographic separation column (42) and/or said feeding device (3); releasing said collected gaseous chemical compounds in a temporally focused manner by means of said thermally based collecting device (41); separating said released gaseous chemical compounds by means of said gas chromatographic separation column (42); and analyzing said separated gaseous chemical compounds by means of an analyzer (5). The present invention further relates to a device (1) for performing such a method.

摘要翻译： 本发明涉及一种用于气流的重复化学分析的方法，其中所述气流由载气和气态化合物组成，包括以下方法步骤：将所述气流通过气相色谱分离柱（42）输送到气相色谱分离柱 装置（3）的装置; 通过耦合到所述气相色谱分离柱（42）和/或所述进料装置（3）的热基收集装置（41）收集至少一部分所述气态化合物达一定时间。 通过所述热基收集装置（41）以时间聚焦的方式释放所述收集的气态化合物; 通过所述气相色谱分离柱（42）分离所述释放的气态化合物; 并通过分析仪（5）分析所述分离的气态化合物。 本发明还涉及一种用于执行这种方法的装置（1）。