公开(公告)号：EP3168618A1

公开(公告)日：2017-05-17

申请号：EP16193284.3

申请日：2007-04-04

Applicant: Singulex, Inc. ,  The Regents of the University of California

Inventor： Goix, Philippe ,  Puskas, Robert ,  Todd, John ,  Livingston, Richard ,  Held, Douglas ,  Wu, Alan H.

IPC: G01N33/68

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods for the sensitive detection of cardiac troponin. Such methods are used in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供了用于心肌肌钙蛋白的灵敏检测的方法。 这些方法用于涉及心脏肌钙蛋白释放的病症的诊断，预后和治疗方法的确定。

公开(公告)号：EP3077798A1

公开(公告)日：2016-10-12

申请号：EP14821017.2

申请日：2014-12-05

Applicant: QUIDEL CORPORATION

Inventor： BOOKER, David, Dickson ,  STEADMAN, Jhobe

IPC: G01N21/27 ,  G01N21/64 ,  G01N33/558

CPC classification number: G01N21/645 ,  G01N21/274 ,  G01N21/278 ,  G01N33/54386 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/10 ,  G01N2201/12746 ,  G01N2201/12753 ,  G01N2201/12761

Abstract: Disclosed herein is a method for improving the precision of a test result from an instrument with an optical system that detects a signal. The method comprises including in the instrument a normalization target disposed directly or indirectly in the optical path of the optical system. Also disclosed are instruments comprising a normalization target, and systems comprising such an instrument and a test device that receives a sample suspected of containing an analyte.

公开(公告)号：EP2016394A2

公开(公告)日：2009-01-21

申请号：EP07861282.7

申请日：2007-04-04

Applicant: Singulex, Inc.

Inventor： GOIX, Philippe ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas

IPC: G01N21/76 ,  G01N21/64

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供了方法，组合物，试剂盒和系统，用于心脏肌钙蛋白的灵敏的检测。 搜索方法，组合物，试剂盒和系统诊断，预后有重要意义，并在条件治疗方法的决心做了包括心肌肌钙蛋白的释放。

公开(公告)号：EP0353591A3

公开(公告)日：1991-03-20

申请号：EP89113616.0

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

公开(公告)号：EP0335915A1

公开(公告)日：1989-10-11

申请号：EP88902688.0

申请日：1988-02-29

Applicant: ELECTRONIC INSTRUMENTATION AND TECHNOLOGY, INC.

Inventor： MAY, Joe, T. ,  CASACIA, Edward, A.

IPC: G01N21 ,  G01J1

CPC classification number: G01N21/251 ,  G01J1/1626 ,  G01J2001/161 ,  G01N21/8507 ,  G01N2201/0693 ,  G01N2201/12761

Abstract: A portable, battery powered instrument for measuring the amount of material dissolved in a liquid solution employs electro-optic technology based on the Beer-Lambert Law. A sample probe (14) is inserted in a solution to be measured. The results of the measurement are displayed on a display (22). The displayed results are frozen for a predetermined period of time at the expiration of which, the power is turned off to conserve battery power.

公开(公告)号：EP2002260B1

公开(公告)日：2015-11-04

申请号：EP07754941.8

申请日：2007-04-04

Applicant: Singulex, Inc. ,  The Regents of the University of California

Inventor： GOIX, Philippe ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas ,  WU, Alan H.

IPC: G01N33/53

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

公开(公告)号：EP2386858B1

公开(公告)日：2015-07-15

申请号：EP11169710.8

申请日：2007-04-04

Applicant: Singulex, Inc. ,  The Regents of the University of California

Inventor： Goix, Philippe ,  Puskas, Robert ,  Todd, John ,  Livingston, Richard ,  Held, Douglas ,  Wu, Alan H.

IPC: G01N33/53 ,  G01N21/64 ,  G01N33/68 ,  G01N33/58

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统可用于涉及心肌肌钙蛋白释放的病症中的治疗方法的诊断，预后和测定。

公开(公告)号：EP2386858A1

公开(公告)日：2011-11-16

申请号：EP11169710.8

申请日：2007-04-04

Applicant: Singulex, Inc.

Inventor： The designation of the inventor has not yet been filed

IPC: G01N33/53 ,  G01N21/64 ,  G01N33/68 ,  G01N33/58

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

公开(公告)号：EP0353591B1

公开(公告)日：1996-04-17

申请号：EP89113616.0

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

公开(公告)号：EP0353591A2

公开(公告)日：1990-02-07

申请号：EP89113616.0

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

Abstract translation: 提供半自动化生物样品分析仪和子系统，以同时对多个生物样品中的每一个中预先选择的过敏原的一组特异性的himan IgE类抗体进行多次酶免疫测定。 提供转盘以定位和保持多个反应盒。 每个反应盒包括在包含在反应井内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于含有要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器，以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。