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    DETECTION AND QUANTIFICATION OF GLYCOSYLATED PEPTIDES
    2.
    发明公开
    DETECTION AND QUANTIFICATION OF GLYCOSYLATED PEPTIDES 审中-实审

    公开(公告)号：EP4407318A2

    公开(公告)日：2024-07-31

    申请号：EP24182906.8

    申请日：2019-07-12

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： ROSENBERG, Avraham Z. ,  SHEN, Biao

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6848 ,  G01N33/6842 ,  G01N2440/3820130101

    摘要： A method of purification and/or separation of glycopeptides and quantitation of same. The method includes contacting a sample comprising glycopeptides to a hydrophilic enrichment substrate under conditions that permit the glycopeptides to bind to the hydrophilic enrichment substrate. The glycopeptides are eluted from the hydrophilic enrichment substrate with an ammonium formate and acetonitrile (ACN) in water solution to create an enriched glycopeptide sample, which may be subjected to analysis to identify specific glycopeptides.

    DETECTION AND QUANTIFICATION OF GLYCOSYLATED PEPTIDES
    3.
    发明公开
    DETECTION AND QUANTIFICATION OF GLYCOSYLATED PEPTIDES 审中-公开

    公开(公告)号：EP4407318A3

    公开(公告)日：2024-10-02

    申请号：EP24182906.8

    申请日：2019-07-12

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： ROSENBERG, Avraham Z. ,  SHEN, Biao

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6848 ,  G01N33/6842 ,  G01N2440/3820130101

    摘要： A method of purification and/or separation of glycopeptides and quantitation of same. The method includes contacting a sample comprising glycopeptides to a hydrophilic enrichment substrate under conditions that permit the glycopeptides to bind to the hydrophilic enrichment substrate. The glycopeptides are eluted from the hydrophilic enrichment substrate with an ammonium formate and acetonitrile (ACN) in water solution to create an enriched glycopeptide sample, which may be subjected to analysis to identify specific glycopeptides.