公开(公告)号：EP1889048A4

公开(公告)日：2010-12-22

申请号：EP06752779

申请日：2006-06-08

申请人： MDS INC DOING BUSINESS THROUGH ,  APPLIED BIOSYSTEMS CANADA LTD

发明人： LE BLANC YVES ,  BLOOMFIELD NICHOLAS

IPC分类号： G01N30/88 ,  G01N30/72 ,  G01N37/00 ,  H01J49/26

CPC分类号： G01N30/8675 ,  G01N30/72 ,  G01N30/861 ,  G01N30/8641 ,  H01J49/0031

摘要： Methods and systems for obtaining mass spectrographic data of a substance. Methods include subjecting a substance to a chromatographic process or other separating process, ionizing the output thereof, and subjecting the ionized output to recursive mass spectrometry analyses; and provide improved processing and analysis of data acquired during the repeated analyses. Systems according to one aspect of the invention comprise ion sources, mass spectrometers capable of analyzing ions of selected mass, and controllers adapted to receive from the mass spectrometers and retain signals representing data representing pluralities of mass spectrograms. The controllers can be adapted to generate information useful for describing extracted ion chromatograms, using data associated with the pluralities of mass spectrograms and non-linear curve approximation algorithms; and to use the generated information to generate further information useful in further analysis of the ionized substance.

公开(公告)号：EP4409279A1

公开(公告)日：2024-08-07

申请号：EP22786953.4

申请日：2022-09-27

申请人： Merck Patent GmbH

发明人： KERVENNIC, Damien ,  MOISSONNIER, Philippe

IPC分类号： G01N30/88 ,  G01N30/86 ,  B01D15/20

CPC分类号： G01N30/88 ,  G01N2030/88920130101 ,  G01N30/861 ,  G01N30/8617

公开(公告)号：EP3315959A1

公开(公告)日：2018-05-02

申请号：EP17198692.0

申请日：2017-10-26

申请人： ARKRAY, Inc.

发明人： KAWANO, Masao

IPC分类号： G01N27/447 ,  G01N30/86

CPC分类号： G01N27/44721 ,  G01N21/27 ,  G01N27/44769 ,  G01N27/44791 ,  G01N30/861 ,  G01N33/48707 ,  G01N2030/8648

摘要： An analytical method and an analytical system capable of more accurate analysis, in which a sample is analyzed by a capillary electrophoresis technique in which a voltage is applied to a sample solution introduced to a micro flow path (27)7, a separation analysis is performed for a component contained in the sample solution, and an optically measured value corresponding to an elapsed time after starting a measurement is measured. The analytical method comprises: a process of determining an interface arrival time point, based on the optically measured value when an interface between the sample solution and a migration liquid reaches a predetermined measurement position in the micro flow path; and a process of identifying the component contained in the sample solution using the optically measured value at the elapsed time after the interface arrival time point.

摘要翻译： 一种能够进行更精确分析的分析方法和分析系统，其中通过毛细管电泳技术分析样品，其中将电压施加到引入微流路（27）7的样品溶液中，执行分离分析 测定试样溶液中含有的成分，测定与测定开始后的经过时间对应的光学测定值。 该分析方法包括：基于当样本溶液和迁移液体之间的界面到达微流径中的预定测量位置时的光学测量值来确定界面到达时间点的过程; 以及使用在界面到达时间点之后的经过时间处的光学测量值来识别包含在样本溶液中的组分的过程。

公开(公告)号：EP3252465A4

公开(公告)日：2018-01-17

申请号：EP15879857

申请日：2015-01-26

申请人： SHIMADZU CORP

发明人： KOZAWA HIROAKI

IPC分类号： G01N30/86

CPC分类号： G01N30/861 ,  G01N30/8641 ,  G01N30/8675 ,  G01N30/8686

摘要： In a method for estimating a noise level representing the magnitude of a noise component from measurement data, first waveform data composed of high frequency noise components extracted from assumed noise data are divided into segments so that each section where positive values successively occur or each section where negative values successively occur in the first waveform data is defined as one segment (Step S3). A segment-width threshold is determined based on the distribution of the widths of the segments (Step S4). Second waveform data composed of high frequency noise components extracted from measurement data are divided into segments so that each section where positive values successively occur or each section where negative values successively occur in the second waveform data is defined as one segment (Step S6). Each segment having a width larger than the threshold is excluded from the segments in the second waveform data, to create a first segment group (Step S7). The noise level is determined based on the heights or areas of the plurality of segments included in the first segment group.

公开(公告)号：EP3252465A1

公开(公告)日：2017-12-06

申请号：EP15879857.9

申请日：2015-01-26

申请人： Shimadzu Corporation

发明人： KOZAWA, Hiroaki

IPC分类号： G01N30/86

CPC分类号： G01N30/861 ,  G01N30/8641 ,  G01N30/8675 ,  G01N30/8686

摘要： In a method for estimating a noise level representing the magnitude of a noise component from measurement data, first waveform data composed of high frequency noise components extracted from assumed noise data are divided into segments so that each section where positive values successively occur or each section where negative values successively occur in the first waveform data is defined as one segment (Step S3). A segment-width threshold is determined based on the distribution of the widths of the segments (Step S4). Second waveform data composed of high frequency noise components extracted from measurement data are divided into segments so that each section where positive values successively occur or each section where negative values successively occur in the second waveform data is defined as one segment (Step S6). Each segment having a width larger than the threshold is excluded from the segments in the second waveform data, to create a first segment group (Step S7). The noise level is determined based on the heights or areas of the plurality of segments included in the first segment group.

摘要翻译： 在用于根据测量数据估计表示噪声分量的大小的噪声电平的方法中，将由从假定噪声数据提取的高频噪声分量构成的第一波形数据分成多个分段，使得连续出现正值的每个分段或者其中每个分段 将第一波形数据中连续出现的负值定义为一个段（步骤S3）。 基于区段宽度的分布来确定区段宽度阈值（步骤S4）。 由从测量数据提取的高频噪声分量构成的第二波形数据被分成多段，使得第二波形数据中正值连续出现的每个部分或者连续出现负值的每个部分被定义为一个段（步骤S6）。 从第二波形数据中的段中排除具有大于阈值的宽度的每个段以创建第一段组（步骤S7）。 基于包括在第一片段组中的多个片段的高度或面积来确定噪声水平。

公开(公告)号：EP1315964B1

公开(公告)日：2012-12-26

申请号：EP01968619.5

申请日：2001-09-07

申请人： Waters Technologies Corporation

发明人： GORENSTEIN, Marc, V.

IPC分类号： G01N30/86 ,  G01N30/82 ,  G06F17/00

CPC分类号： G01N30/8624 ,  G01N30/82 ,  G01N30/8603 ,  G01N30/861 ,  G01N30/8627 ,  G01N30/8631 ,  G01N30/8634 ,  G01N30/8641

公开(公告)号：EP1315964A4

公开(公告)日：2008-09-24

申请号：EP01968619

申请日：2001-09-07

申请人： WATERS INVESTMENTS LTD

发明人： GORENSTEIN MARC V

IPC分类号： G01N27/62 ,  G01N33/50 ,  G01N30/62 ,  G01N30/72 ,  G01N30/74 ,  G01N30/80 ,  G01N30/82 ,  G01N30/86 ,  G06F17/00

CPC分类号： G01N30/8624 ,  G01N30/82 ,  G01N30/8603 ,  G01N30/861 ,  G01N30/8627 ,  G01N30/8631 ,  G01N30/8634 ,  G01N30/8641

摘要： An improved method and apparatus for identifying peaks and for determining the boundaries of those peaks, and boundaries of multiple peaks and shoulders within chromatograms (184). The method and apparatus effects real time identification and determination of the boundaries of these peaks for the purpose of fraction collection. The method and apparatus determines the boundary of a peak within a detector response profile that comprises data points plotted graphically on an X and Y-axis wherein the X-axis represents a first variable and the Y-axis represents a second variable, each variable having a value. The plot at each of the data points has a slope. Data points having a slope which deviates from a consistent value define a peak, and data points having a slope with a consistent value define a baseline.

公开(公告)号：EP1889048A1

公开(公告)日：2008-02-20

申请号：EP06752779.6

申请日：2006-06-08

申请人： MDS Inc. doing business through its MDS Sciex Division

发明人： LE BLANC, Yves ,  BLOOMFIELD, Nicholas

IPC分类号： G01N30/88 ,  G01N30/72 ,  G01N37/00 ,  H01J49/26

CPC分类号： G01N30/8675 ,  G01N30/72 ,  G01N30/861 ,  G01N30/8641 ,  H01J49/0031

摘要： Methods and systems for obtaining mass spectrographic data of a substance. Methods include subjecting a substance to a chromatographic process or other separating process, ionizing the output thereof, and subjecting the ionized output to recursive mass spectrometry analyses; and provide improved processing and analysis of data acquired during the repeated analyses. Systems according to one aspect of the invention comprise ion sources, mass spectrometers capable of analyzing ions of selected mass, and controllers adapted to receive from the mass spectrometers and retain signals representing data representing pluralities of mass spectrograms. The controllers can be adapted to generate information useful for describing extracted ion chromatograms, using data associated with the pluralities of mass spectrograms and non-linear curve approximation algorithms; and to use the generated information to generate further information useful in further analysis of the ionized substance.

公开(公告)号：EP1315964A2

公开(公告)日：2003-06-04

申请号：EP01968619.5

申请日：2001-09-07

申请人： Waters Investments Limited ,  Gorenstein, Marc V.

发明人： GORENSTEIN, Marc, V.

IPC分类号： G01N33/50

CPC分类号： G01N30/8624 ,  G01N30/82 ,  G01N30/8603 ,  G01N30/861 ,  G01N30/8627 ,  G01N30/8631 ,  G01N30/8634 ,  G01N30/8641

摘要： An improved method and apparatus for identifying peaks and for determining the boundaries of those peaks, and boundaries of multiple peaks and shoulders within chromatograms (184). The method and apparatus effects real time identification and determination of the boundaries of these peaks for the purpose of fraction collection. The method and apparatus determines the boundary of a peak within a detector response profile that comprises data points plotted graphically on an X and Y-axis wherein the X-axis represents a first variable and the Y-axis represents a second variable, each variable having a value. The plot at each of the data points has a slope. Data points having a slope which deviates from a consistent value define a peak, and data points having a slope with a consistent value define a baseline.