公开(公告)号：EP4010692B1

公开(公告)日：2024-09-25

申请号：EP20756797.5

申请日：2020-08-07

IPC分类号： G01N30/06 ,  G01N30/86 ,  G01N30/04 ,  H01J49/00

CPC分类号： G01N30/8606 ,  G01N30/8613 ,  G01N30/8637 ,  G01N2030/04520130101 ,  G01N30/8617 ,  H01J49/0036 ,  G01N30/8631

公开(公告)号：EP3410109A1

公开(公告)日：2018-12-05

申请号：EP17174385.9

申请日：2017-06-02

申请人： Thermo Fisher Scientific (Bremen) GmbH

发明人： PFAFF, Hans ,  HENRICH, Christoph ,  MALEK, Robert ,  THAM, Katja

IPC分类号： G01N30/86 ,  H01J49/00 ,  G01N30/72

CPC分类号： H01J49/0036 ,  G01N30/72 ,  G01N30/8631 ,  G01N2030/8648 ,  H01J49/0004

摘要： A computer implemented method of extracting a mass trace from mass spectrometry data of a mass stream emitted from a separation device as a function of a separation parameter, wherein the mass spectrometry data are generated by analysis in a mass spectrometer, the method comprising, receiving the mass spectrometry data, wherein the mass spectrometry data comprise a plurality of mass spectra each obtained for respective values of the separation parameter; identifying, from the plurality of mass spectra, a sequence of three or more intensity peaks that are ordered according to the separation parameter, wherein said identifying the sequence of three or more intensity peaks comprises, selecting an initial intensity peak at an initial mass, and for each other intensity peak of the sequence of intensity peaks, selecting said intensity peak based on at least the mass of an adjacent intensity peak in the sequence of intensity peaks, the method further comprising, providing a mass trace, for a given emitted compound of the mass stream, from the identified sequence of intensity peaks.

公开(公告)号：EP3315962A1

公开(公告)日：2018-05-02

申请号：EP17808737.5

申请日：2017-07-14

申请人： LG Chem, Ltd.

发明人： CHOI, Heung Yeal ,  KIM, No Ma ,  KIM, Yu Jin

IPC分类号： G01N30/88 ,  B01J20/281

CPC分类号： G01N30/88 ,  B01D15/426 ,  B01J20/103 ,  B01J20/283 ,  G01N30/34 ,  G01N30/48 ,  G01N30/8631 ,  G01N2030/486 ,  G01N2030/885 ,  G01N33/445

摘要： The present invention relates to a method for measuring a polymer modification ratio, and more particularly, to a method for measuring a polymer modification ratio, which includes preparing a first solution by dissolving a polymer mixture containing a modified polymer and an unmodified polymer in a first solvent, injecting the first solution into a column filled with an adsorbent, adsorbing the modified polymer onto the adsorbent, and eluting the first solution in which the unmodified copolymer is dissolved, transferring the eluted first solution to a detector, injecting a second solvent into the column to elute the second solution in which the adsorbed modified polymer is dissolved, and transferring the eluted second solution to the detector.

摘要翻译： 本发明涉及一种测量聚合物改性比率的方法，更具体地说，涉及一种测量聚合物改性比率的方法，该方法包括通过将含有改性聚合物和未改性聚合物的聚合物混合物溶解在第一溶液 将第一溶液注入填充有吸附剂的柱中，将改性聚合物吸附到吸附剂上，并洗脱其中溶解有未改性共聚物的第一溶液，将洗脱的第一溶液转移到检测器中，将第二溶剂注入 柱以洗脱其中溶解有吸附改性聚合物的第二溶液，并将洗脱的第二溶液转移至检测器。

公开(公告)号：EP3009435B1

公开(公告)日：2016-08-17

申请号：EP14189007.9

申请日：2014-10-15

申请人： F.I.S.- Fabbrica Italiana Sintetici S.p.A.

发明人： Brasola, Elena ,  Tomasi, Filippo

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  G01N30/8631 ,  G01N2030/027

摘要： Object of the present invention is an improved process for the preparation of Apixaban, through new intermediates which undergo to a faster amidation reaction. Impurities of Apixaban are also identified and quantified.

摘要翻译： 本发明的目的是通过经历更快的酰胺化反应的新中间体来制备阿哌沙班的改进方法。 阿哌沙班的杂质也被鉴定和量化。

公开(公告)号：EP1997050B1

公开(公告)日：2016-08-10

申请号：EP07763418.6

申请日：2007-02-06

申请人： Siemens Healthcare Diagnostics Inc.

发明人： IZMAILOV, Alexandre, M. ,  YUWARAJ, Murugathas

IPC分类号： G06F19/24 ,  G01N30/86

CPC分类号： G01N30/8624 ,  G01N30/8631

公开(公告)号：EP2850645A4

公开(公告)日：2016-02-24

申请号：EP13790450

申请日：2013-04-19

申请人： DH TECHNOLOGIES DEV PTE LTD

发明人： TATE STEPHEN ,  BONNER RONALD F

IPC分类号： H01J49/00

CPC分类号： H01J49/0045 ,  G01N30/7233 ,  G01N30/8631 ,  G06F19/703 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/004

摘要： Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor. The two or more target widths can have the same width or variable widths. A tandem mass spectrometer is instructed to perform two or more fragmentation scans across the mass range using the processor. Each fragmentation scan of the two or more fragmentation scans includes a measured mass selection window width. The two or more measured widths of the two or more fragmentation scans can have the same width or variable widths. At least two of the two or more measured mass selection window widths overlap. The overlap in measured mass selection window widths corresponds to at least one target mass selection window width.

摘要翻译： 提供了系统和方法，用于使用重叠的测量质量选择窗口宽度来分析样本。 使用处理器将样本的质量范围分为两个或更多个目标质量选择窗口宽度。 两个或多个目标宽度可以具有相同的宽度或可变宽度。 指示串联质谱仪使用处理器在质量范围内执行两次或多次碎片扫描。 两个或多个碎片扫描的每个碎片扫描包括测量的质量选择窗口宽度。 两个或更多个碎片扫描的两个或多个测量宽度可以具有相同的宽度或可变宽度。 两个或更多个测量质量选择窗口宽度中的至少两个重叠。 测量的质量选择窗口宽度中的重叠对应于至少一个目标质量选择窗口宽度。

公开(公告)号：EP2837933A4

公开(公告)日：2015-06-24

申请号：EP12873982

申请日：2012-04-12

申请人： SHIMADZU CORP

发明人： ASANO NATSUYO

IPC分类号： H01J49/00 ,  G01N30/72

CPC分类号： G01N30/8631 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/86 ,  H01J49/0009 ,  H01J49/0036 ,  H01J49/005

摘要： An equation expressing a previously and experimentally determined relationship between the number of ions and a CV value is stored in a reference CV value calculation data memory (44). When a mass spectrometry is performed for a target sample under measurement conditions including a loop time Tp and a dwell time Td, a chromatogram creator (41) creates a chromatogram based on the analysis result and calculates a peak area value A. A CV-value-related information calculator (43) computes the number X of ions by X=Ax(Td/Tp), and based on the equation stored in the memory (44), calculates a CV value corresponding to the calculated number of ions. This is a reference CV value containing only statistical dispersion factors for data. This CV value is displayed in such a manner that it can be compared with an actual CV value calculated based on the variance of actually measured peak area values corresponding to a plurality of measurements, which allows analysis operators to make judgments on the actual measurement data, e.g. whether or not the data are valid.

公开(公告)号：EP2322922B1

公开(公告)日：2015-02-25

申请号：EP10173746.8

申请日：2010-08-23

申请人： Thermo Fisher Scientific (Bremen) GmbH

发明人： Pfaff, Hans

IPC分类号： G01N30/72 ,  G01N30/86 ,  G01N30/74

CPC分类号： G01N30/72 ,  G01N30/02 ,  G01N30/74 ,  G01N30/8624 ,  G01N30/8631 ,  G01N30/8637 ,  G01N30/8675

公开(公告)号：EP2837933A1

公开(公告)日：2015-02-18

申请号：EP12873982.8

申请日：2012-04-12

申请人： Shimadzu Corporation

发明人： ASANO, Natsuyo

IPC分类号： G01N27/62 ,  G01N30/72 ,  G01N30/86

CPC分类号： G01N30/8631 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/86 ,  H01J49/0009 ,  H01J49/0036 ,  H01J49/005

摘要： An equation expressing a previously and experimentally determined relationship between the number of ions and a CV value is stored in a reference CV value calculation data memory (44). When a mass spectrometry is performed for a target sample under measurement conditions including a loop time Tp and a dwell time Td, a chromatogram creator (41) creates a chromatogram based on the analysis result and calculates a peak area value A. A CV-value-related information calculator (43) computes the number X of ions by X=Ax(Td/Tp), and based on the equation stored in the memory (44), calculates a CV value corresponding to the calculated number of ions. This is a reference CV value containing only statistical dispersion factors for data. This CV value is displayed in such a manner that it can be compared with an actual CV value calculated based on the variance of actually measured peak area values corresponding to a plurality of measurements, which allows analysis operators to make judgments on the actual measurement data, e.g. whether or not the data are valid.

摘要翻译： 在参考CV值计算数据存储器（44）中存储表示先前和实验确定的离子数与CV值之间的关系的等式。 当在包括循环时间Tp和停留时间Td的测量条件下对目标样品进行质谱分析时，色谱图创建器（41）基于分析结果创建色谱图并计算峰面积值A. CV值 （43）通过X = Ax（Td / Tp）计算离子数X，并基于存储在存储器（44）中的公式计算与计算出的离子数对应的CV值。 这是一个参考CV值，仅包含数据的统计扩散因子。 该CV值以能够与根据与多个测定对应的实际测定的峰值面积值的方差而计算出的实际的CV值进行比较的方式进行显示，由此，分析人员能够对实际的测定数据进行判断， 例如 无论数据是否有效。

公开(公告)号：EP2717047A1

公开(公告)日：2014-04-09

申请号：EP12792398.5

申请日：2012-05-31

申请人： TSUMURA & CO.

发明人： MORI, Yoshikazu ,  NODA, Keiichi

IPC分类号： G01N30/86 ,  G01N30/88

CPC分类号： G01N30/04 ,  G01N30/463 ,  G01N30/8624 ,  G01N30/8631 ,  G01N30/8675 ,  G01N30/8686 ,  G06F19/703 ,  G06K9/00496

摘要： An evaluating apparatus, capable of contributing to improve the accuracy and the efficiency of an evaluation of an evaluation target, includes a FP preparing part 3 that prepares a target FP configured by peaks, retention time points and UV spectra thereof detected from a 3D chromatogram of a multicomponent drug that is an evaluation target at a specific wavelength, a reference FP selecting part 5 that selects a reference FP that is appropriate for assigning peaks of the target FP from among a plurality of reference FPs, a peak pattern preparing part 7 that prepares a peak pattern that is configured by, for example, three peaks including two peaks that are present at least on one of sides located in front and rear in a time axis direction for each peak of the target FP and the selected reference FP, a peak assigning part 9 that specifies corresponding peaks by comparing the peak patterns and the UV spectra of the peaks, and an evaluating part that compares and evaluates the assigned peaks and the peaks of the plurality of reference FPs by, for example, MT method.

摘要翻译： 能够有助于提高评价对象的评价的准确性和效率的评价装置包括：FP准备部3，其准备由从其三维色谱图的三维色谱图中检测出的峰，保留时间点和紫外光谱构成的目标FP 作为特定波长的评价对象的多组分药物，从多个基准FP中选择适合于分配目标FP的峰值的基准FP的基准FP选择部5，准备好的峰值图形准备部7 峰值图案由例如三个峰构成，包括对于目标FP和所选参考FP的每个峰位于时间轴方向上的至少一个侧面中的至少一个侧面的两个峰值，峰值 通过比较峰的峰值图案和紫外光谱来分配指定相应峰的部分9，以及评估部分，其比较和评估所分配的pe 例如通过MT方法，将多个基准FP的峰值和峰值进行比较。