公开(公告)号：EP1380329B1

公开(公告)日：2014-02-19

申请号：EP03015452.0

申请日：2003-07-09

申请人： Shimadzu Corporation

发明人： Waki, Hiroaki

IPC分类号： B01D15/08 ,  G01N30/82 ,  G01N30/78

CPC分类号： B01D15/247 ,  G01N30/7233 ,  G01N30/74 ,  G01N30/78 ,  G01N30/82 ,  Y10T436/24 ,  G01N21/47

公开(公告)号：EP2376208A4

公开(公告)日：2013-08-28

申请号：EP09832241

申请日：2009-12-10

申请人： ALLTECH ASSOCIATES INC

发明人： ANDERSON JAMES M JR ,  BYSTRON JOSEF P ,  MENDOZA WASHINGTON J ,  SAARI-NORDHAUS RAAIDAH ,  HELGEMO DIRK ,  LEWIS STEVE ,  NELSON SHELDON ,  FROHMAN BRUCE ,  KLEIN NICK

IPC分类号： G01N30/82 ,  B01D15/08 ,  G01N30/60 ,  G01N35/10

CPC分类号： G01N30/82 ,  B01D15/08 ,  B01D15/10 ,  B01D15/247 ,  G01N30/6091 ,  G01N35/00732 ,  G01N2035/00782 ,  G01N2035/00811 ,  G01N2035/041

公开(公告)号：EP2467466A1

公开(公告)日：2012-06-27

申请号：EP11778349.8

申请日：2011-05-05

申请人： Alltech Associates Inc.

发明人： SAARI-NORDHAUS, Raaidah ,  GAITA, Romulus ,  MENDOZA, Washington ,  ANDERSON, James ,  ANDERSON, Scott

IPC分类号： C12M1/36 ,  G01N35/10 ,  G01N21/84

CPC分类号： G01N30/82 ,  G01N30/74 ,  G01N30/78 ,  G01N30/84 ,  G01N35/1097 ,  G01N2030/8447

摘要： Methods and apparatus for analyzing a sample using at least one detector in a liquid chromatography system and collecting a new sample fraction in a fraction collector in response to a change in the signal are disclosed.

公开(公告)号：EP2376208A1

公开(公告)日：2011-10-19

申请号：EP09832241.5

申请日：2009-12-10

申请人： Alltech Associates Inc.

发明人： ANDERSON, James, M., Jr. ,  BYSTRON, Josef, P. ,  MENDOZA, Washington, J. ,  SAARI-NORDHAUS, Raaidah ,  HELGEMO, Dirk ,  LEWIS, Steve ,  NELSON, Sheldon ,  FROHMAN, Bruce ,  KLEIN, Nick

IPC分类号： B01D15/08

CPC分类号： G01N30/82 ,  B01D15/08 ,  B01D15/10 ,  B01D15/247 ,  G01N30/6091 ,  G01N35/00732 ,  G01N2035/00782 ,  G01N2035/00811 ,  G01N2035/041

摘要： Chromatography systems and components suitable for use in chromatography systems are disclosed. Methods of making chromatography systems and components suitable for use in chromatography systems and methods of using chromatography systems and components suitable for use in chromatography systems are also disclosed.

公开(公告)号：EP1370867A1

公开(公告)日：2003-12-17

申请号：EP02723286.7

申请日：2002-03-01

申请人： Activx Biosciences, Inc. ,  Patricelli, Matthew

发明人： Patricelli, Matthew

IPC分类号： G01N33/53 ,  G01N33/543

CPC分类号： G01N33/6848 ,  G01N30/7233 ,  G01N30/74 ,  G01N30/82 ,  G01N30/8675 ,  G01N33/6818 ,  G01N33/6842 ,  G01N33/6851 ,  Y10T436/24 ,  Y10T436/25125 ,  G01N21/64

摘要： Methods and compositions are described for analyzing complex protein mixtures, such as proteomes, using activity-based probes. In particular, probes that specifically react with and bind to the active form of one or more target proteins are employed. Labeled peptides obtained from the labeled active target proteins can be used in screening and identification procedures, and can be related to the identity, presence, amount, or activity of active members of the desired target protein class. The methods and compositions described herein can be used, for example, to provide diagnostic information concerning pathogenic states, in identifying proteins that may act as therapeutic targets, and in drug discovery.

公开(公告)号：EP1330306A2

公开(公告)日：2003-07-30

申请号：EP01977713.5

申请日：2001-10-10

申请人： BioTrove, Inc.

发明人： HESS, Robert, A. ,  KANIGAN, Tanya, S. ,  BRENAN, Colin, J., H. ,  OZBAL, Can ,  LINTON, John, Dudley

IPC分类号： B01J19/00

CPC分类号： G01N30/466 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/0036 ,  B01J2219/00369 ,  B01J2219/00387 ,  B01J2219/00389 ,  B01J2219/00423 ,  B01J2219/0043 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00673 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/0268 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5085 ,  B01L99/00 ,  B01L2200/0657 ,  B01L2300/0845 ,  C40B60/14 ,  G01N30/6095 ,  G01N30/82 ,  G01N2030/8417 ,  Y10T29/301 ,  Y10T29/49938

摘要： The invention features methods of making devices, or "platens", having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.

公开(公告)号：EP1325320A1

公开(公告)日：2003-07-09

申请号：EP01974189.1

申请日：2001-08-14

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： TOMMASI, Ruben, Alberto

IPC分类号： G01N30/10

CPC分类号： G01N30/10 ,  G01N30/82 ,  G01N2030/347 ,  Y10T137/0491 ,  Y10T137/794 ,  Y10T137/85938

摘要： This invention refers to a microsplitter in flow systems especially used for separation techniques in analytical chemistry such as microliquid chromatography (MLC), high pressure liquid chromatography (HPLC) and ancillary techniques. The splitter system comprises a microsplitter and a micromixer which are connected by a microbore tubing. A high collection rate and high resolution of the sample peak are achieved by the proper choice of tubing length and diameters and the use of a back pressure regulator to obtain a controlled split ratio.

公开(公告)号：EP0486030B1

公开(公告)日：1997-01-15

申请号：EP91119468.6

申请日：1991-11-14

申请人： SHIMADZU CORPORATION

发明人： Mito, Yasuhiro

IPC分类号： G01N30/82 ,  G01N30/80

CPC分类号： G01N30/82 ,  G01J2003/2873 ,  G01N30/74 ,  G01N30/8624 ,  G01N30/8689 ,  G01N35/085 ,  G01N2201/12753

公开(公告)号：EP0662013A1

公开(公告)日：1995-07-12

申请号：EP94922707.0

申请日：1994-07-20

申请人： ISCO, Inc.

发明人： ALLINGTON, Robert, William ,  WALTERS, Henry, Leroy ,  JAMESON, Daniel, Gene ,  TEHRANI, Yoossef

IPC分类号： B01D15 ,  B01D11 ,  G01N1 ,  G01N30

CPC分类号： B01D11/0203 ,  B01D11/0407 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N30/32 ,  G01N30/60 ,  G01N30/82 ,  G01N2030/6008 ,  G01N2030/6013 ,  B01D15/40

摘要： A variable-orifice fluid restrictor (11) for use with a supercritical extractor or chromatograph includes an inlet line for fluid at a pressure above its critical pressure, an extended tubular probe having an inner and an outer surface and a proximal and a distal end. The proximal end of the probe is disposed toward the inlet line. The distal end of the probe includes an adjustable orifice means (1240) adapted for metering the fluid and having first and second orifice members and an adjusting stem having first and second ends. The adjustable orifice means (1240) is adjacent to the outer surface of the probe and the orifice means (1240) is adjustable with the adjusting stem. The end of the stem is located at the distal end of the probe and is adapted for moving the first orifice member with respect to the second orifice member to control the adjustable orifice (1240) for varying the restriction of the fluid passing through the adjustable orifice (1240).

公开(公告)号：EP0533909A4

公开(公告)日：1993-06-30

申请号：EP92910887

申请日：1992-03-20

申请人： PERSEPTIVE BIOSYSTEMS, INC.

发明人： AFEYAN, NOUBAR, B. ,  REGNIER, FRED, E.

IPC分类号： B01D15/08 ,  G01N27/447 ,  G01N30/14 ,  G01N30/46 ,  G01N30/52 ,  G01N30/62 ,  G01N30/80 ,  G01N30/82 ,  G01N30/86 ,  G01N30/88

CPC分类号： G01N30/461 ,  B01D15/08 ,  G01N27/44717 ,  G01N30/62 ,  G01N30/82 ,  G01N2030/143 ,  G01N2030/524 ,  G01N2030/625 ,  G01N2030/8813 ,  G01N2030/8831

摘要： Disclosed is a method and apparatus for the rapid identification of a solute of interest in an effluent stream (14). The method involves separation of the solutes in the effluent (14) and identification of a particular solute of interest by its selective subtraction from the effluent stream (14). The effluent stream (14) from a first system (12) capable of partitioning the components of the mixture is passed through a detector (16) to produce a first output (18) which describes the temporal and/or spacial sequence of the mixture components exiting the first system (12). The effluent stream (14) is then passed through a second system (20) capable of selectively extracting a solute of interest from said effluent stream (14) and is then passed through a detector (16).