公开(公告)号：EP2616867B1

公开(公告)日：2018-10-24

申请号：EP11740929.2

申请日：2011-08-08

申请人： Carl Zeiss Microscopy GmbH

发明人： SPRENGER, Joerg

IPC分类号： G02B21/02

CPC分类号： G02B21/025

公开(公告)号：EP3203292A4

公开(公告)日：2018-06-06

申请号：EP15847607

申请日：2015-08-12

申请人： SONY CORP

发明人： HATAKEYAMA TAKESHI ,  MIYATANI SOTA ,  TAMURA MASAKI ,  OOHATA ATSUSHI ,  SATO MIKI

IPC分类号： G02B15/167 ,  A61B3/12 ,  G02B15/16 ,  G02B15/173 ,  G02B21/00 ,  G02B21/02 ,  G02B21/22 ,  G02B21/36

CPC分类号： G02B21/0012 ,  A61B3/12 ,  G02B15/173 ,  G02B21/025 ,  G02B21/18 ,  G02B21/22 ,  G02B21/361 ,  G02B23/2446

摘要： An image quality is improved although a medical stereomicroscope optical system and a medical observation apparatus are small and light. An objective optical system and a plurality of imaging optical systems are arranged in an order from an object side to an image side, and the imaging optical system has at least a single aspheric surface. Accordingly, a spherical aberration and a field curvature are improved, and the image quality is improved although the medical stereomicroscope optical system and a medical observation apparatus are small and light.

公开(公告)号：EP3299862A1

公开(公告)日：2018-03-28

申请号：EP17168330.3

申请日：2017-04-27

申请人： Olympus Corporation

发明人： NAKATSUKA, Masayuki

IPC分类号： G02B21/36 ,  G06T3/40 ,  G06T7/20 ,  G06T11/60 ,  H04N5/232 ,  G06K9/20

CPC分类号： G02B21/367 ,  G02B21/025 ,  G02B21/26 ,  G06K2009/2045 ,  G06T3/4038 ,  G06T7/20 ,  G06T11/60 ,  H04N5/23238

摘要： A wide-field-angle overlapped image and a currently-observed visual field range can be simultaneously ascertained without using an electrically-driven stage or an encoder-equipped stage. Provided is a microscope imaging system (1) including: a stage (5) on which a sample (X) is placed and that is movable in a direction intersecting an observation optical axis; an imaging unit (6) that acquires an image of the sample (X) placed on the stage (5) at time intervals; a motion vector calculating unit (9) that calculates a motion vector between two images acquired by the imaging unit (6); and an image generating unit (10) that generates an overlapped image by overlapping the image acquired by the imaging unit (6) with a current position where the motion vector is cumulatively added, and that also generates a composite image by combining display of the current position with the overlapped image.

摘要翻译： 无需使用电驱动台或带编码器的台，可以同时确定宽视场角重叠图像和当前观察的视场范围。 本发明提供一种显微镜摄像系统（1），其具备载置试料（X）并且能够在与观察光轴交叉的方向上移动的载物台（5） 成像单元（6），其以时间间隔获取放置在平台（5）上的样本（X）的图像; 运动矢量计算单元（9），其计算由成像单元（6）所获取的两个图像之间的运动矢量; 和图像生成单元（10），其通过将由成像单元（6）获取的图像与累积地添加运动矢量的当前位置重叠来生成重叠图像，并且还通过组合显示电流来生成合成图像 与重叠图像的位置。

公开(公告)号：EP2184633B1

公开(公告)日：2017-11-15

申请号：EP08829374.1

申请日：2008-08-27

申请人： Nikon Corporation

发明人： NAKAYAMA, Hiroaki

IPC分类号： G02B21/02 ,  G02B15/173 ,  G02B15/20

CPC分类号： G02B21/025 ,  G02B15/173 ,  G02B15/20

摘要： A variable power relay optical system comprising: a variable power lens performing zooming a secondary image based on light from a primary image; and a rear group forming the secondary image based on the light passing through the variable power lens; the variable power lens consisting of, in order from the primary image side, a first group G1 having positive power, a second group G2 having negative power, a third group G4 [sic] having positive power, and a fourth group G5 [sic] having positive power, upon zooming from a high magnification end to a low magnification end, the fourth group G4 being moved to the secondary image side, and a distance between the first group G1 and the second group G2 increasing, positions of the primary image and the secondary image, an entrance pupil of the variable power relay optical system, a pupil of the variable power lens, and an exit pupil of the variable power relay optical system being substantially kept constant, and the pupil of the variable power lens being disposed to the secondary image side of the last surface of the variable power lens.

公开(公告)号：EP3204811A1

公开(公告)日：2017-08-16

申请号：EP15780801.5

申请日：2015-10-01

申请人： Leica Microsystems (Schweiz) AG

发明人： SCHNITZLER, Harald ,  PAULUS, Robert

IPC分类号： G02B21/02 ,  G02B21/08 ,  G02B21/12

CPC分类号： G02B21/006 ,  G02B21/0032 ,  G02B21/0044 ,  G02B21/02 ,  G02B21/025 ,  G02B21/082 ,  G02B21/125

摘要： The invention relates to a microscope (10) for detecting images of an object (14) lying in an object plane (12). Said microscope comprises a microscope stand (18), a microscope lens (20), a light source (22) integrated into the microscope stand (18), and a beam splitter (24) integrated into the microscope lens (20) for coupling in coaxial incident light illumination.

摘要翻译： 本发明涉及一种用于检测位于物体平面（12）中的物体（14）的图像的显微镜（10）。 所述显微镜包括显微镜支架（18），显微镜透镜（20），集成到显微镜支架（18）中的光源（22）和集成到显微镜透镜（20）中的分束器（24） 同轴入射光照明。

公开(公告)号：EP2345920A4

公开(公告)日：2017-07-05

申请号：EP09817878

申请日：2009-10-02

申请人： NIPPON KOGAKU KK

发明人： WAKAMATSU TAKASHI ,  SUZUKI AKITOSHI

IPC分类号： G02B21/00

CPC分类号： G02B21/025 ,  G02B15/00 ,  G02B21/00

摘要： The present invention relates to a microscope system configured to allow operability to be improved. An electric zoom 21 consecutively changes a magnification for a sample. Furthermore, a revolver 24 includes a plurality of objective lenses of different magnifications and switches the objective lens placed in an observation optical path to intermittently change the magnification for the sample. The control section 34 calculates a total magnification at which the sample is observed based on a magnification provided by the electric zoom 21 and the magnification of the objective lens currently placed in the observation optical path. The control section 34 operates when the revolver 24 switches the objective lens placed in the observation optical path, to determine a target magnification that is the magnification of the electric zoom 21 required to keep the total magnification obtained after the switching of the objective lens equal to the total magnification obtained before the switching of the objective lens. Then, the electric zoom control section 32 controls the electric zoom 21 in such a manner that the magnification of the electric zoom 21 is set equal to the target magnification. The present invention is applicable to, for example, a stereoscopic microscope.

摘要翻译： 显微镜系统技术领域本发明涉及一种显微镜系统，其被配置为允许可操作性得到改进。 电动变焦21连续地改变样本的放大率。 此外，转轮24包括多个具有不同倍率的物镜，并且切换放置在观察光路中的物镜以间歇地改变样品的放大率。 控制部分34基于由电动变焦21提供的倍率和当前放置在观察光路中的物镜的倍率来计算观察样品的总倍率。 当旋转器24切换放置在观察光路中的物镜时，控制部分34进行操作，以确定作为电子变焦21的倍率的目标倍率，该倍率是为了保持在物镜切换之后获得的总倍率等于 在物镜切换之前获得的总放大倍率。 然后，电动变焦控制部分32以电动变焦21的倍率被设定为等于目标倍率的方式控制电动变焦21。 本发明适用于例如立体显微镜。

公开(公告)号：EP2833779A1

公开(公告)日：2015-02-11

申请号：EP13716661.7

申请日：2013-03-29

申请人： Bioptigen, Inc.

发明人： BUCKLAND, Eric L. ,  FARMIGA, Nestor O. ,  HART, Robert H. ,  MURNAN, Andrew ,  SAXER, Christopher

IPC分类号： A61B3/10 ,  A61B3/13

CPC分类号： A61B3/102 ,  A61B3/13 ,  A61B3/132 ,  A61B5/0066 ,  G01B9/02039 ,  G01B9/02091 ,  G02B1/11 ,  G02B21/0012 ,  G02B21/0048 ,  G02B21/006 ,  G02B21/02 ,  G02B21/025 ,  G02B27/0031 ,  G02B27/0955 ,  G02B27/141

摘要： Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.

摘要翻译： 本发明构思的一些实施例提供了用于与显微镜集成的光学相干断层摄影（OCT）系统。 OCT系统包括耦合到显微镜的成像路径的样品臂。 采样臂包括输入光束变焦组件，其包括至少两个配置成为OCT信号光束提供形状控制的可移动透镜; 扫描组件，其包括至少一个扫描反射镜并被配置为用于远程扫描所述OCT信号光束; 以及光束扩展器，其配置成设置入射在显微镜物镜上的OCT信号光束直径。 形状控制包括成像OCT束的数值孔​​径和焦点位置的可分离控制。

公开(公告)号：EP1887402B1

公开(公告)日：2014-12-31

申请号：EP07014991.9

申请日：2007-07-31

申请人： Olympus Corporation

发明人： Fukuyama, Hiroya

IPC分类号： G02B21/00 ,  G02B21/02 ,  G02B23/24 ,  G02B21/33

CPC分类号： G02B21/0012 ,  G02B21/025 ,  G02B21/33 ,  G02B23/2438

公开(公告)号：EP2798391A2

公开(公告)日：2014-11-05

申请号：EP12806222.1

申请日：2012-11-21

申请人： President and Fellows of Harvard College

发明人： COHEN, Adam, E. ,  MACLAURIN, Dougal ,  HOCHBAUM, Daniel ,  KRALJ, Joel

IPC分类号： G02B21/00

CPC分类号： G02B21/367 ,  G01N21/6486 ,  G01N2201/06113 ,  G02B21/0076 ,  G02B21/0084 ,  G02B21/025 ,  G02B21/082 ,  G02B21/16 ,  G02B21/361

摘要： Various aspects of the present invention are generally directed to systems and methods for imaging at high spatial and/or temporal resolutions. In one aspect, the present invention is generally directed to an optical microscopy system and related methods adapted for high spatial and temporal resolution of dynamic processes. The system may be used in conjunction with fluorescence imaging wherein the fluorescence may be mediated by voltage-indicating proteins. In some cases, time resolutions may be enhanced by fitting predefined temporal waveforms to signal values received from an image. The system may also contain a high numerical aperture objective lens and a zoom lens located in an imaging optical path to an object region. Other aspects of the present invention are generally directed to techniques of making or using such systems, kits involving such systems, manufactured storage devices able to implement such systems or methods, and the like.

公开(公告)号：EP2715429A2

公开(公告)日：2014-04-09

申请号：EP12731044.9

申请日：2012-05-23

申请人： Université de Lorraine ,  Centre National de la Recherche Scientifique

发明人： DUMAS, Dominique ,  HUPONT, Sébastien

IPC分类号： G02B21/02 ,  G02B21/00 ,  G01N21/63

CPC分类号： G02B21/025 ,  G01N21/6408 ,  G01N21/6458 ,  G02B21/0048 ,  G02B21/006 ,  G02B21/0076 ,  G02B2207/114

摘要： The present invention relates to a MACRO-MULTIPHOTON, in particular with SHG modality (MACRO-SHG), that is to say a biomedical imaging installation, able to implement a multiphoton excitation, of a sample comprising intrinsic chromophores sensitive to excitation by excitation photons (1) having an energy chosen to produce emission photons (11), comprising: at least one source (2) capable of producing pulses of synchronized excitation photons (1), - a means (3) of scanning said pulses of excitation photons (1) through a chosen zone of the sample (10), - means (7, 19) for local focusing of said pulses of excitation photons (1) on said sample (10), and - means (6, 17) for directing the emission photons (11) towards at least one collection zone (12, 13, 14, 15, 16). Said focusing means comprise a variable-magnification optical system. The invention also relates to a method of biomedical imaging using such an installation, as well as to its application for mapping the molecules of collagen of a biological tissue, and/or of cellulose and/or of starch of a plant sample without exogenous marker, and in a non-invasive and non-destructive manner.