摘要:
The present invention relates to a process for purifying and concentrating 68 Ga isotope produced by the irradiation with an accelerated particle beam of a 68 Zn target in solution. The process according to the invention allows for the production of pure and concentrated 68 Ga isotope in hydrochloric acid solution. The present invention also relates to a disposable cassette (500) suitable to perform the steps of purification and concentration of the process.
摘要:
Die vorliegende Erfindung betrifft einen 68 Ga-Generator, bei welchem dessen 68 Ge-Mutternuklid spezifisch an einen Träger über eine Triethoxyphenylgruppe immobilisiert ist und kontinuierlich zu 68 Ga zerfällt, wobei die Triethoxyphenylgruppe kovalent über einen Linker an ein Trägermaterial gebunden ist.
摘要:
Die vorliegende Erfindung betrifft einen 68 Ga-Generator, bei welchem dessen 68 Ge-Mutternuklid spezifisch an einen Träger über eine Triethoxyphenylgruppe immobilisiert ist und kontinuierlich zu 68 Ga zerfällt, wobei die Triethoxyphenylgruppe kovalent über einen Linker an ein Trägermaterial gebunden ist.
摘要:
The present invention relates to a 68 Ge/ 68 Ga generator for a continuous production of a 68 Ga daughter nuclide, wherein the 68 Ge parent nuclide thereof is specifically adsorbed to an inorganic support material and wherein said 68 Ge parent nuclide continuously decays to 68 Ga by electron capture at a half-life of 270.82 d, wherein the inorganic support material is at least one oxide of a metal being selected from the group consisting of: Vanadium, Niobium and Tantalum. The invention relates further to the use of at least one oxide of a metal being selected from the group consisting of: Vanadium, Niobium and Tantalum as an inorganic support material for the manufacture of a 68 Ge/ 68 Ga generator for pharmaceutical purposes.
摘要:
Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61CU, 99mTC, 45-Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.
摘要:
Methods for producing a radioisotope by a charged particle irradiation of a fluid target matrix are provided. A method of producing a radioisotope includes irradiating a fluid target matrix comprising a compound of a target isotope with a charged particle beam to transform at least a portion of the target isotope to the radioisotope, and isolating the radioisotope from the irradiated fluid target matrix. The target isotope may be an isotope of cadmium, an isotope of thallium, an isotope of zinc, an isotope of gallium, an isotope of tellurium, an isotope of molybdenum, an isotope of rhodium, an isotope of selenium, an isotope of nickel, an isotope of yttrium, an isotope of strontium, an isotope of bismuth, an isotope of tungsten, and an isotope of titanium, provided that the target isotope is not Mo-100.
摘要:
Chromatography columns for the purification of eluates from 68Ge/68Ga generators comprising silica as stationary phase and purification processes that use said columns are described.
摘要:
The present invention provides a Ge adsorbent for a 68 Ge- 68 Ga generator, which is a polysaccharide polymer having a glucamine group represented by the formula (1) or the formula (2), wherein R 1 is a hydrogen atom or an alkyl group, and * is a bonding position.