68 Ga-Generator
    3.
    发明公开
    68 Ga-Generator 有权
    68 Ga发生器

    公开(公告)号:EP2439747A8

    公开(公告)日:2013-01-02

    申请号:EP11176249.8

    申请日:2011-08-02

    IPC分类号: G21G1/00 A61K51/12

    摘要: Die vorliegende Erfindung betrifft einen 68 Ga-Generator, bei welchem dessen 68 Ge-Mutternuklid spezifisch an einen Träger über eine Triethoxyphenylgruppe immobilisiert ist und kontinuierlich zu 68 Ga zerfällt, wobei die Triethoxyphenylgruppe kovalent über einen Linker an ein Trägermaterial gebunden ist.

    摘要翻译: 本发明涉及一种68Ga-发生器,其中所述母体核素68Ge是特定固定于经由Triethoxyphenylgruppe载体和连续分解为68Ga,其中所述Triethoxyphenylgruppe共价通过接头与载体材料结合。

    68 Ga-Generator
    4.
    发明公开
    68 Ga-Generator 有权
    68 Ga发电机

    公开(公告)号:EP2439747A2

    公开(公告)日:2012-04-11

    申请号:EP11176249.8

    申请日:2011-08-02

    IPC分类号: G21G1/00

    摘要: Die vorliegende Erfindung betrifft einen 68 Ga-Generator, bei welchem dessen 68 Ge-Mutternuklid spezifisch an einen Träger über eine Triethoxyphenylgruppe immobilisiert ist und kontinuierlich zu 68 Ga zerfällt, wobei die Triethoxyphenylgruppe kovalent über einen Linker an ein Trägermaterial gebunden ist.

    摘要翻译: 用于镓-68子核素的发生器包括锗-68亲核素,其通过三羟基苯基或二羟基苯基特异性地固定在载体上。 固定在载体上的母体核素通过电子捕获连续衰减270.82天的半衰期,得到镓-68子体核素。 三羟基苯基或二羟基苯基通过包含2-20℃的酯,2-20℃的亚烷基,苯基硫脲,2-20℃的胺,三聚氰胺或三羟基苯基烷氧基硅烷的接头共价键合到载体材料上。 用于镓-68子核素的发生器包括锗-68亲核素,其通过三羟基苯基或二羟基苯基特异性地固定在载体上。 固定在载体上的母体核素通过电子捕获连续衰减270.82天的半衰期,得到镓-68子体核素。 三羟基苯基或二羟基苯基通过包含2-20℃的酯,2-20℃的亚烷基,苯基硫脲,2-20℃的胺,三聚氰胺或三羟基苯基烷氧基硅烷,优选地为1,2,3,4-二羟基苯基的接头共价键合到载体材料上 三羟基苯基三乙氧基硅烷,1,2,3-三羟基苯基二乙氧基硅烷,1,2,3-三羟基苯基乙氧基硅烷,1,2,3-三羟基苯基三丙氧基硅烷,1,2,3-三羟基苯基氯硅烷,表氯醇,异硫氰酸酯或硫醇。

    SOLUTION TARGET FOR CYCLOTRON PRODUCTION OF RADIOMETALS

    公开(公告)号:EP3142709A4

    公开(公告)日:2017-12-20

    申请号:EP15793539

    申请日:2015-05-15

    IPC分类号: A61K51/00

    摘要: Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61CU, 99mTC, 45-Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

    GENERAL RADIOISOTOPE PRODUCTION METHOD EMPLOYING PET-STYLE TARGET SYSTEMS
    7.
    发明公开
    GENERAL RADIOISOTOPE PRODUCTION METHOD EMPLOYING PET-STYLE TARGET SYSTEMS 有权
    制作广播同位素性质的PET目标系统的一般方法

    公开(公告)号:EP2715739A1

    公开(公告)日:2014-04-09

    申请号:EP12727012.2

    申请日:2012-06-01

    IPC分类号: G21G1/10 G21G1/00

    摘要: Methods for producing a radioisotope by a charged particle irradiation of a fluid target matrix are provided. A method of producing a radioisotope includes irradiating a fluid target matrix comprising a compound of a target isotope with a charged particle beam to transform at least a portion of the target isotope to the radioisotope, and isolating the radioisotope from the irradiated fluid target matrix. The target isotope may be an isotope of cadmium, an isotope of thallium, an isotope of zinc, an isotope of gallium, an isotope of tellurium, an isotope of molybdenum, an isotope of rhodium, an isotope of selenium, an isotope of nickel, an isotope of yttrium, an isotope of strontium, an isotope of bismuth, an isotope of tungsten, and an isotope of titanium, provided that the target isotope is not Mo-100.