公开(公告)号：EP3188756A2

公开(公告)日：2017-07-12

申请号：EP15808270.1

申请日：2015-09-01

申请人： Cadila Healthcare Limited

发明人： GUPTA, Gaurav ,  FICHERA, Epifanio ,  GLUECK, Reinhard

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61P33/02 ,  A61K39/008 ,  A61K39/145

CPC分类号： A61K39/008 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55588 ,  C12N7/00 ,  C12N2760/16034 ,  Y02A50/41 ,  Y02A50/412

摘要： The present invention is directed to a preparation of an adjuvant system to achieve required level of humoral and cellular immune response against antigen of interest. The current invention provides an adjuvant system comprising an immunostimulating reconstituted influenza virosomes (IRIVs) and immunopotentiators. The current invention illustrates that an antigen is adsorbed or incorporated into IRIVs and further formulated with lipophilic adjuvant such as MPL or glucopyranosyl lipid adjuvant (synthetic analogue of MPL).

摘要翻译： 本发明涉及佐剂系统的制备，以获得针对感兴趣抗原的所需水平的体液和细胞免疫应答。 本发明提供了包含免疫刺激重构流感病毒体（IRIV）和免疫增强剂的佐剂系统。 本发明说明抗原被吸附或掺入IRIV中，并进一步与亲脂性佐剂例如MPL或吡喃葡萄糖基脂佐剂（MPL的合成类似物）一起配制。

公开(公告)号：EP3365006A1

公开(公告)日：2018-08-29

申请号：EP16797992.1

申请日：2016-10-17

申请人： Cadila Healthcare Limited

发明人： FICHERA, Epifanio ,  GUPTA, Gaurav ,  GLUECK, Reinhard

IPC分类号： A61K39/12 ,  A61K39/00 ,  A61K39/015

CPC分类号： A61K39/39 ,  A61K39/0008 ,  A61K39/0012 ,  A61K39/015 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5254 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/55588 ,  A61K2039/70 ,  A61P9/00 ,  A61P31/16 ,  A61P31/20 ,  A61P33/06 ,  C12N7/00 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2710/20071 ,  C12N2760/00034 ,  C12N2760/00071 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16134 ,  Y02A50/394 ,  Y02A50/41 ,  Y02A50/412

摘要： The present invention relates to certain polyphenol(s) having adjuvant property that can be used for the vaccine preparation. Also, the current invention provides adjuvant system comprising said polyphenol(s) and delivery system such as an immunostimulating reconstituted influenza virosomes (IRIVs). The present invention illustrates the said polyphenol(s) or an adjuvant system comprising of such polyphenol(s) and IRIVs can provide better level of immune response against antigen of interest than conventional vaccine systems. The preferred polyphenol according to the present invention can be beta-sitosterol. Beta-sitosterol can be optionally combined with the known adjuvant(s) to enhance immune response.

公开(公告)号：EP3274447A1

公开(公告)日：2018-01-31

申请号：EP16721253.9

申请日：2016-03-28

申请人： Cadila Healthcare Limited

发明人： GLUECK, Reinhard ,  GIANNINO, Viviana ,  GUPTA, Gaurav

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C12N7/04 ,  C12N2760/18721 ,  C12N2760/18734 ,  C12N2760/18751 ,  C12N2760/18761

摘要： The present invention provides a novel vaccine against mumps composed of highly immunogenic rMuVJL2 (recombinant mumps virus Jeryl Lynn2 based). Further, method to develop said immunogenic composition is described in the present invention. The vaccine according to the present invention is safe, cost effective, highly efficacious and stable and consistent in terms of productivity.

公开(公告)号：EP3609532A1

公开(公告)日：2020-02-19

申请号：EP18725910.6

申请日：2018-04-12

申请人： Cadila Healthcare Limited

发明人： JAIN, Mukul ,  GIRI, Suresh ,  BAHEKAR, Rajesh ,  GUPTA, Gaurav ,  CHOPADE, Rajendra

IPC分类号： A61K39/00 ,  C12N9/64 ,  A61K47/64

公开(公告)号：EP3191505A2

公开(公告)日：2017-07-19

申请号：EP15808033.3

申请日：2015-09-11

申请人： Cadila Healthcare Limited

发明人： GUPTA, Gaurav ,  GIANNINO, Viviana ,  GLUECK, Reinhard

IPC分类号： C07K14/025 ,  A61K39/12 ,  C07K14/005 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/55505 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2710/20051 ,  C12N2710/20071 ,  C12N2800/22

摘要： The present invention provides genes encoding various HPV antigens of several serotypes. The gene of the present invention produce virus like particles with an improved immunological quality and quartnary structure. The present invention also provides suitable host cell preferably
P.pastoris with high copy number of genes encoding various HPV antigens of several serotypes. The present invention further provides vaccine against HPV antigens with improved immunization schedule wherein vaccine dosage regiment and amount of antigen dose are reduced. The present invention also provides an improved human papilloma virus vaccine composition using yeast.

摘要翻译： 本发明提供编码几种血清型的各种HPV抗原的基因。 本发明的基因产生具有改善的免疫学质量和四元结构的病毒样颗粒。 本发明还提供了合适的宿主细胞，优选具有编码多种血清型的各种HPV抗原的基因的高拷贝数的巴斯德毕赤酵母。 本发明进一步提供了具有改进的免疫方案的针对HPV抗原的疫苗，其中疫苗剂量方案和抗原剂量的量降低。 本发明还提供了使用酵母的改进的人乳头瘤病毒疫苗组合物。