Abstract:
The present disclosure relates to a semipermeable membrane. The present disclosure aims to provide a semipermeable membrane having tolerance against a decrease over time in substance permeability. The present disclosure provides a semipermeable membrane (10) containing a resin. The permeation rate of albumin in the semipermeable membrane (10) is no lower than 30%. The albumin adsorption amount obtained when the semipermeable membrane (10) measuring 1 cm on each side is immersed in a 0.1% albumin solution for 90 minutes is no greater than 10 µg/cm 2 . The water permeation amount obtained when water is sucked through the semipermeable membrane (10) at a negative pressure of 3±0.2 kPa is expressed by no smaller than 1,000 L/(m 2 ·hour). The semipermeable membrane (10) can isolate a cell from an external environment.
Abstract:
A virus removal membrane 10 for removing viruses from a protein-containing solution, the virus removal membrane 10 including a primary surface 1 to which the protein-containing solution is applied, and a secondary surface 2 from which a liquid that permeates through the virus removal membrane 10 is flowed, wherein the virus removal membrane is formed from cellulose, in which, when a solution containing gold colloids having a diameter of 20 nm is applied through the primary surface to the virus removal membrane to allow the virus removal membrane 10 to capture the gold colloids for measurement of brightness in a cross section of the virus removal membrane 10, a value obtained by dividing a standard deviation of a value of an area of a spectrum of variation in the brightness by an average of the value of the area is 0.01 or more and 1.5 or less; and a thickness of a portion, where gold colloids having a diameter of 20 nm or more and 30 nm or less are captured, in the cross section of the virus removal membrane 10 in a wet state is 10.0 µm or more and 30.0 µm or less.
Abstract:
A method of preparing a porous separator using cellulose nanofibrils is provided. The method includes preparing a sheet using a solution including cellulose nanofibrils and a pore-forming resin and removing the pore-forming resin included in the sheet to form micropores.
Abstract:
Provided is a simple method for producing a cell concentrate (other than human blood) in a short time with neither loss of cells nor an excessive burden on cells. Included is a method for producing a cell concentrate using an inside-out filtration system for processing a cell suspension, the system including: a cell suspension inlet port; a filtrate outlet port; a cell suspension outlet port; and hollow fiber separation membranes provided between the cell suspension inlet port and the cell suspension outlet port, wherein the membranes have a total cross-sectional area of 0.5-1.5 cm 2 , the membranes have an inside membrane area of 0.2 m 2 or less, the suspension is flowed inside the membranes at a linear velocity of 500-1200 cm/min, and the quotient of the division of the initial filtrate flow rate from the filtrate outlet port by the flow rate into the cell suspension inlet port is 0.4-0.7.