VIRUS REMOVAL MEMBRANE
    8.
    发明公开
    VIRUS REMOVAL MEMBRANE 审中-公开
    VIRUSENTFERNUNGSMEMBRAN

    公开(公告)号:EP3130393A4

    公开(公告)日:2017-05-03

    申请号:EP15777331

    申请日:2015-04-10

    Abstract: A virus removal membrane 10 for removing viruses from a protein-containing solution, the virus removal membrane 10 including a primary surface 1 to which the protein-containing solution is applied, and a secondary surface 2 from which a liquid that permeates through the virus removal membrane 10 is flowed, wherein the virus removal membrane is formed from cellulose, in which, when a solution containing gold colloids having a diameter of 20 nm is applied through the primary surface to the virus removal membrane to allow the virus removal membrane 10 to capture the gold colloids for measurement of brightness in a cross section of the virus removal membrane 10, a value obtained by dividing a standard deviation of a value of an area of a spectrum of variation in the brightness by an average of the value of the area is 0.01 or more and 1.5 or less; and a thickness of a portion, where gold colloids having a diameter of 20 nm or more and 30 nm or less are captured, in the cross section of the virus removal membrane 10 in a wet state is 10.0 µm or more and 30.0 µm or less.

    Abstract translation: 从含有蛋白质的溶液中去除病毒的病毒去除膜10,病毒去除膜10包括施加有含蛋白质溶液的主表面1和次级表面2,从中渗透通过病毒去除的液体 膜10流动,其中病毒去除膜由纤维素形成,其中当通过主表面将包含具有20nm直径的金胶体的溶液施加至病毒去除膜以允许病毒去除膜10捕获 用于测量病毒去除膜10的横截面中的亮度的金胶体,通过将亮度变化的光谱的面积的值的标准偏差除以该面积的值的平均值而获得的值是 0.01以上且1.5以下; 在湿润状态下的病毒去除膜10的截面中,捕捉直径为20nm以上且30nm以下的金胶体的部分的厚度为10.0μm以上且30.0μm以下 。

    METHOD FOR PRODUCING CELL CONCENTRATE
    10.
    发明公开
    METHOD FOR PRODUCING CELL CONCENTRATE 审中-公开
    方法生产体浓缩物

    公开(公告)号:EP2891710A4

    公开(公告)日:2016-05-18

    申请号:EP13832933

    申请日:2013-08-19

    Applicant: KANEKA CORP

    Inventor: TANIGUCHI SHUHEI

    Abstract: Provided is a simple method for producing a cell concentrate (other than human blood) in a short time with neither loss of cells nor an excessive burden on cells. Included is a method for producing a cell concentrate using an inside-out filtration system for processing a cell suspension, the system including: a cell suspension inlet port; a filtrate outlet port; a cell suspension outlet port; and hollow fiber separation membranes provided between the cell suspension inlet port and the cell suspension outlet port, wherein the membranes have a total cross-sectional area of 0.5-1.5 cm 2 , the membranes have an inside membrane area of 0.2 m 2 or less, the suspension is flowed inside the membranes at a linear velocity of 500-1200 cm/min, and the quotient of the division of the initial filtrate flow rate from the filtrate outlet port by the flow rate into the cell suspension inlet port is 0.4-0.7.

Patent Agency Ranking