Verfahren zur Reinigung von Methacrylamidopropyltrimethylammoniumchlorid und verwandten Verbindungen
    3.
    发明公开
    Verfahren zur Reinigung von Methacrylamidopropyltrimethylammoniumchlorid und verwandten Verbindungen 失效
    一种用于净化methacrylamidopropyltrimethylammonium和相关化合物的方法。

    公开(公告)号:EP0133504A2

    公开(公告)日:1985-02-27

    申请号:EP84108645.7

    申请日:1984-07-21

    申请人: RÖHM GMBH

    CPC分类号: C07C233/89

    摘要: Zur Reinigung von Methacrylamidopropyltrimethylammoniumchlorid oder ähnlichen quaternierten Aminoalkylestern oder Aminoalkylamiden der Acryl- oder Methacrylsäure von Verunreinigungen, die durch Hofmann'schen Abbau der genannten Verbindungen entstehen können, wie z.B. Allylmethacrylamid, wird eine wäßrige Lösung der Verbindung mit Dichlormethan extrahiert.

    摘要翻译: 甲基丙烯酰胺丙基三甲基氯化铵和季铵化的类似氨基烷基酯或丙烯酸或甲基丙烯酸的aminoalkylamides由水溶液用二氯甲烷萃取以除去杂质,:例如烯丙基甲基丙烯酰胺,其可以通过所述化合物的一个霍夫曼降解可以形成它们的纯化。

    Selective binding compounds for 5-hydroxytryptamine 1-A-receptors and pharmaceutical compositions containing them
    7.
    发明公开
    Selective binding compounds for 5-hydroxytryptamine 1-A-receptors and pharmaceutical compositions containing them 失效
    化合物为含有它们的选择性S-羟色胺1-A受体的结合和药物组合物。

    公开(公告)号:EP0338877A1

    公开(公告)日:1989-10-25

    申请号:EP89400817.6

    申请日:1989-03-23

    摘要: Compounds that selectively bind 5-HT 1A recep­tors in preference to other 5-HT receptors are provided along with methods for their use. Such compounds have the formula
    wherein A is an aromatic group selected to provide, with the glycidyl residue that forms the next portion of the molecule, a 5-HT-like portion of the molecule that represents the primary binding site of the mole­cule with a 5-HT receptor; X represents a quarternary carbon and its attached alkyl groups; Y represents a hydrocarbon linking group; Z represents hydrogen or an organic group containing up to 12 carbon and/or hetero­atoms in its skeletal structure; and R¹ and R² inde­pendently represent hydrogen or an alkyl group. The aromatic group is most preferably indole or an indole derivative.

    摘要翻译: 化合物选择性结合并优先于其它5-HT受体的5-HT1A受体地连同它们的使用方法提供。 搜索化合物具有下式 worin A为选择,以提供芳族基团,具有缩水甘油基残基并形成分子的下一部分,该分子的5-HT状部分那样darstellt分子的主要结合位点 用5-HT受体; X darstellt季碳和其连接的烷基; Y表示的烃基连接基团; Z代表氢或有机基团,以含最多12个碳和/或在其骨架结构的杂原子; 和R <1>和R <2>unabhängig表示氢或烷基对。 所述芳族基团是最优选的吲哚或吲哚衍生物的。

    ESTERS OF ARYLOXYPROPANOLAMINE DERIVATIVES AND USE AS BETA-ADRENERGIC BLOCKING AGENTS
    9.
    发明授权
    ESTERS OF ARYLOXYPROPANOLAMINE DERIVATIVES AND USE AS BETA-ADRENERGIC BLOCKING AGENTS 失效
    芳基丙氨酰胺衍生物的酯类和用作抗坏血酸阻断剂

    公开(公告)号:EP0093155B1

    公开(公告)日:1986-08-27

    申请号:EP82903622.7

    申请日:1982-10-28

    摘要: Compounds of the formula wherein R1 is lower alkyl, lower cycloalkyl, lower alkenyl, lower alkynyl, lower alkyl carboxymethyl, aryl carboxymethyl, aryl, or aralkyl; A is a direct bond, lower alkylene, or lower alkenylene; x is 1 or 2, provided that when x is greater than 1, different occurences of the R1-O-C-A- group may be the same or different; Ar is heterocyclic, unsubstituted aromatic or aromatic substituted with lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halogen, acetamido, amino, nitro, lower alkylamino, hydroxy, lower hydroxyalkyl or cyano; W is alkylene containing from 1 to about 10 carbon atoms; and B is -NR2COR3, -NR2CONR3R4, -NR2SO2R3, -NR2SO2NR3R4, or -NR2COOR5, wherein R2, R3, R4 and R5 may be the same or different and may be hydrogen, alkyl, alkoxyalkyl, alkoxyaryl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, or aralkyl, except that R3 and R5 are not hydrogen when B is -NR2SO2R3 or -NR2COOR5, or R3 and R4 may together with N form a 5 to 7 membered heterocyclic group; and the pharmaceutically acceptable salts thereof. The compounds of the present invention are beta -adrenergic blocking agents useful in the treatment of cardiac disorders, glaucoma, or the lowering of elevated intraocular pressure.