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    Fluorescent indicator dyes for calcium ions
    3.
    发明公开
    Fluorescent indicator dyes for calcium ions 失效
    荧光指示剂钙离子指示剂

    公开(公告)号：EP0178775A3

    公开(公告)日：1986-08-27

    申请号：EP85306387

    申请日：1985-09-09

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Tsien, Roger Yonchien ,  Grynkiewicz, Grzegorz

    IPC分类号： C07C101/04 ,  C07C101/72 ,  C07C143/80 ,  C07D209/10 ,  C07D307/78 ,  G01N33/84

    CPC分类号： C07D307/79 ,  C07D209/08 ,  C07D215/40 ,  C07D413/04 ,  Y10S436/80

    摘要： Fluorescent indicator dyes for calcium ions of the formulae:
    or
    wherein
    R' is -H, -CH 3 , -F, -Cl or -Br; R 2 is -H, -CH 3 , -F, -Cl, -Br, or C 1 -C 4 alkoxy; R 3 and R 3 are independently H or -CO 2 H, -CO 2 R 4 , -CONR 5 R 6 , -SO 2 H, -SO 2 NR 5 R 6 , -SO 2 CF 3 , -COCH 3 , or -CN, or R 3 and R 3a together are -(CO)NR 6 (CO)-; R 4 is alpha-acyloxyalkyl or a physiologically acceptable esterifying group; R 5 and R 6 are independently -H, methyl, or ethyl; Z is an aromatic or heteroaromatic system coupled to the 5 position of one 2-aminophenoxy ring through a trans ethylenic linkage, wherein the ethylenic linkage may itself be part of an aromatic or heteroaromatic ring system; W ia H and X is H; or W and X together are O, or NR 6 ; Y is H; Y' is H (unless A is NR 5 , 0, or S); or Y and Y' together are NR 5 and A is C; A and A' are independently C, N, O, or S; D is 0, N, NH, or N alkyl; Q is a double bond when D is N and a single bond otherwise; and R' is H and R 8 is H or R 7 and R 8 , together with heteroatom D, the carbon adjacent R 7 , and the phenyl ring adjacent to R 8 , form a quinoline ring system (D=N, Q=double bond).

    NOUVEAUX DERIVES DE LA BENZAMIDE
    6.
    发明授权
    NOUVEAUX DERIVES DE LA BENZAMIDE 失效
    来自BENZAMIDE的新衍生物

    公开(公告)号：EP0009487B1

    公开(公告)日：1984-05-02

    申请号：EP79900115.1

    申请日：1979-01-10

    申请人： DEBIOPHARM S.A.

    发明人： PURCELL, William, Paul ,  PARISH, Jr., Harlie, A

    IPC分类号： A61K31/63 ,  C07C119/06 ,  C07C143/80 ,  A61K31/165

    CPC分类号： C07C311/39

    摘要： New derivates from benzamide therapeutically active, of the general formula (FORMULA) in which R1 and R2 are, independently from each other, hydrogene or a lower alkyl group, R3 is a phenyl group or a lower alkyl or a lower alkenyl, R4 is a halogene or a trifluormethyl or nitro group, R5 is a sulphamoyl or a carboxyl or a carboalkyl, and the potassium salts of these derivates. These compounds are diuretics and hypotensors and they lower the angiotensin and renin functions, with a prolonged action.

    Preparation of aminosulphonic acids and their derivatives
    10.
    发明公开
    Preparation of aminosulphonic acids and their derivatives 失效
    Herstellung vonAminosulfonsäurenund ihrer Derivate。

    公开(公告)号：EP0025274A1

    公开(公告)日：1981-03-18

    申请号：EP80302729.1

    申请日：1980-08-08

    申请人： IMPERIAL CHEMICAL INDUSTRIES PLC

    发明人： Bamfield, Peter ,  Greenwood, David

    IPC分类号： C07C143/58 ,  C07C143/63 ,  C07C143/68 ,  C07C143/80 ,  C07C139/00 ,  C07D213/73

    CPC分类号： C07D213/73

    摘要： A method for the preparation of a compound of the formula:
    comprising reacting a nitrothiol of the formula:
    with an active hydrogen compound of the formula HY wherein Y represents the residue of the active hydrogen compound after removal of an active hydrogen atom, X together with the carbon atoms to which it is attached, signifies a carbocyclic or heterocyclic ring system and n is an integer of from 0 to 3. The method is especially suitable for the preparation of orthanilic acid, its amides and esters and their ring substituted analogues.
    The products are useful as dyestuff intermediates.

    摘要翻译： 一种制备下式化合物的方法：包括使式：CHEM的硝基硫醇与式HY的活性氢化合物反应，其中Y代表活性氢化合物的残基，除去活性 氢原子，X与其连接的碳原子一起表示碳环或杂环系，n为0至3的整数。该方法特别适用于制备邻氨基苯甲酸，其酰胺和酯， 它们的环取代的类似物。 该产品可用作染料中间体。