公开(公告)号：EP1885684B9

公开(公告)日：2012-04-25

申请号：EP06742964.7

申请日：2006-05-17

申请人： Almirall, S.A.

发明人： PUIG DURAN, Carlos ,  CRESPO CRESPO, Maria, Isabel ,  CASTRO PALOMINO LARIA, Julio, Cesar ,  GUAL ROIG, Silvia ,  NAVARRO ROMERO, Eloisa

IPC分类号： C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26 ,  C07D233/74 ,  A61K31/135 ,  A61K31/415 ,  A61K31/47 ,  A61P11/00

CPC分类号： C07D233/74 ,  C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26

摘要： The present invention provides a compound of formula (I) wherein: R1 is a group selected from -CH2OH, -NHC(O)H and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH- wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2; R3 is selected from hydrogen and halogen atoms or groups selected from -SO-R5, -SO2- R5, -NH-CO-NH2, -CO-NH2, hydantoino, C1-4alkyl, C1-4alkoxy and -SO2NR5R6; R4 is selected from hydrogen atoms, halogen atoms and C1-4alkyl groups; R5 is a C1-4alkyl group or C3-8 cycloalkyl; R6 is independently selected from hydrogen atoms and C1-4alkyl groups; n, p and q are independently 0, 1 , 2, 3 or 4; m and s are independently 0, 1 , 2 or 3; r is 0, 1 or 2; with the provisos that: at least one of m and r is not 0; the sum n+m+p+q+r+s is 7, 8, 9, 10, 11 , 12 or 13; the sum q+r+s is 2, 3, 4, 5 or 6 or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.

公开(公告)号：EP2263998A1

公开(公告)日：2010-12-22

申请号：EP10010410.8

申请日：2006-05-17

申请人： Almirall S.A.

发明人： Puig Duran, Carlos ,  Crespo Crespo, Maria Isabel ,  Castro Palomino Laria, Julio Cesar ,  Gual Roig, Silva ,  Navarro Romero, Eloisa

IPC分类号： C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26 ,  C07D233/74 ,  A61K31/135 ,  A61K31/415 ,  A61K31/47 ,  A61P11/00

CPC分类号： C07D233/74 ,  C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26

摘要： The present invention provides a compound of formula (I):

wherein:
• R 1 is a group selected from -CH 2 OH, -NHC(O)H and
• R 2 is a hydrogen atom; or
• R 1 together with R 2 form the group -NH-C(O)-CH=CH- wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R 1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R 2
• R 3 is selected from hydrogen and halogen atoms or groups selected from -SO-R 5 , -SO 2 -R 5 , -NH-CO-NH 2 , -CO-NH 2 , hydantoino, C 1-4 alkyl, C 1-4 alkoxy and -SO 2 NR 5 R 6
• R 4 is selected from hydrogen atoms, halogen atoms and C 1-4 alkyl groups
• R 5 is a C 1-4 alkyl group or C 3-8 cycloalkyl
• R 6 is independently selected from hydrogen atoms and C 1-4 alkyl groups
• n, p and q are independently 0, 1, 2, 3 or 4
• m and s are independently 0, 1, 2 or 3
• r is 0, 1 or 2
with the provisos that:
• at least one of m and r is not 0
• the sum n+m+p+q+r+s is 7, 8, 9, 10, 11, 12 or 13
• the sum q+r+s is 2, 3, 4, 5 or 6

or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.

摘要翻译： 本发明提供式（I）化合物：其中：R 1为选自-CH 2 OH，-NHC（O）H和R 2为氢原子的基团; 或R 1与R 2一起形成-NH-C（O）-CH = CH-基团，其中氮原子与保护R 1的苯基中的碳原子结合，并且碳原子与碳键合 保护R 2的苯环中的原子R 3选自氢和选自-SO-R 5，-SO 2 -R 5，-NH-CO-NH 2，-CO-NH 2的卤素原子或基团， 乙酰氧基，C 1-4烷基，C 1-4烷氧基和-SO 2 NR 5 R 6 R 6选自氢原子，卤素原子和C 1-4烷基基团R 5为C 1-4 烷基或C 3-8环烷基R 6独立地选自氢原子和C 1-4烷基，n和p分别独立地为0,1,2,3或4，并且s独立地为 0，1，2或3€¢r为0,1或2，但条件是：¢至少有一个m和r不为0¢总和n + m + p + q + r + s为7 ，8,9,10,11,12或13€总和q + r + s为2,3,4,5或6或其药学上可接受的盐，溶剂合物或立体异构体。

公开(公告)号：EP1930312B1

公开(公告)日：2018-02-21

申请号：EP06782529.9

申请日：2006-08-09

申请人： Unimatec Co., Ltd.

发明人： KOKIN, Keisuke ,  SONOI, Takehiro ,  URATA, Kimihiko

IPC分类号： C07C217/26 ,  C07C213/02

CPC分类号： C07C217/26

摘要： An alkylamino group-terminated fluoroether compound, represented by the following general formula : €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒRfO[CF(CF 3 )CF 2 O] m CF(CF 3 )(CH 2 ) n NR 1 R 2 (where Rf is a perfluoro lower-alkyl group, R 1 is an alkyl group having 1-12 carbon atoms, R 2 is a hydrogen atom, or an alkyl group having 1-12 carbon atoms, m is an integer of 0-10, and n is an integer of 3-8) is a novel compound, and is produced by reaction of an iodide-terminated fluoroether compound, represented by the following general formula : €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒRfO[CF(CF 3 )CF 2 O] m CF(CF 3 )(CH 2 ) n I with an alkylamine compound, represented by the following general formula : €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒNHR 1 R 2

公开(公告)号：EP2349967B1

公开(公告)日：2016-03-23

申请号：EP09744515.9

申请日：2009-10-12

申请人： 3M Innovative Properties Company

发明人： FLYNN, Richard M., ,  BULINSKI, Michael J., ,  COSTELLO, Michael G.,

IPC分类号： C07C41/16 ,  C07C43/12 ,  C07C213/06 ,  C07C217/26

CPC分类号： C07C41/16 ,  C07C43/123 ,  C07C43/126 ,  C07C213/06 ,  C07C217/26

公开(公告)号：EP1930312A1

公开(公告)日：2008-06-11

申请号：EP06782529.9

申请日：2006-08-09

申请人： Unimatec Co., Ltd.

发明人： KOKIN, Keisuke ,  SONOI, Takehiro ,  URATA, Kimihiko

IPC分类号： C07C217/26 ,  C07C213/02

CPC分类号： C07C217/26

摘要： An alkylamino group-terminated fluoroether compound, represented by the following general formula :

        RfO[CF(CF 3 )CF 2 O] m CF(CF 3 )(CH 2 ) n NR 1 R 2

(where Rf is a perfluoro lower-alkyl group, R 1 is an alkyl group having 1-12 carbon atoms, R 2 is a hydrogen atom, or an alkyl group having 1-12 carbon atoms, m is an integer of 0-10, and n is an integer of 3-8) is a novel compound, and is produced by reaction of an iodide-terminated fluoroether compound, represented by the following general formula :

        RfO[CF(CF 3 )CF 2 O] m CF(CF 3 )(CH 2 ) n I

with an alkylamine compound, represented by the following general formula :

        NHR 1 R 2

摘要翻译： 由以下通式表示的烷基氨基封端的氟醚化合物：€ƒ€ƒ€ƒ€ƒ€ƒRfO[CF（CF 3）CF 2 O] m CF（CF 3）（CH 2 ）n NR 1 R 2（其中Rf是全氟低级烷基，R 1是具有1-12个碳原子的烷基，R 2是氢原子或具有1-12个碳原子的烷基，m是 0〜10的整数，n为3-8的整数）是新化合物，通过由以下通式表示的碘化物封端的氟醚化合物的反应制得：€ƒ€ƒ€ €ƒ€ƒ€ƒRfO[CF（CF 3）CF 2 O] m CF（CF 3）（CH 2）n I与烷基胺化合物，由以下通式表示：€ƒ€ƒ€ƒ €ƒ€ƒ€ƒNHR1 R 2

公开(公告)号：EP3426643A1

公开(公告)日：2019-01-16

申请号：EP17763731.1

申请日：2017-02-22

申请人： 3M Innovative Properties Company

发明人： SMITH, Sean M. ,  BULINSKI, Michael J. ,  COSTELLO, Michael G. ,  LAMANNA, William M.

IPC分类号： C07D265/30 ,  C07D211/08 ,  C07D241/04 ,  C07D223/04 ,  C07C217/26

公开(公告)号：EP1885684A1

公开(公告)日：2008-02-13

申请号：EP06742964.7

申请日：2006-05-17

申请人： Laboratorios Almirall, S.A.

发明人： PUIG DURAN, Carlos ,  CRESPO CRESPO, Maria, Isabel ,  CASTRO PALOMINO LARIA, Julio, Cesar ,  GUAL ROIG, Silvia ,  NAVARRO ROMERO, Eloisa

IPC分类号： C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26 ,  C07D233/74 ,  A61K31/135 ,  A61K31/415 ,  A61K31/47 ,  A61P11/00

CPC分类号： C07D233/74 ,  C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26

摘要： The present invention provides a compound of formula (I) wherein: R1 is a group selected from -CH2OH, -NHC(O)H and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH- wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2; R3 is selected from hydrogen and halogen atoms or groups selected from -SO-R5, -SO2- R5, -NH-CO-NH2, -CO-NH2, hydantoino, C1-4alkyl, C1-4alkoxy and -SO2NR5R6; R4 is selected from hydrogen atoms, halogen atoms and C1-4alkyl groups; R5 is a C1-4alkyl group or C3-8 cycloalkyl; R6 is independently selected from hydrogen atoms and C1-4alkyl groups; n, p and q are independently 0, 1 , 2, 3 or 4; m and s are independently 0, 1 , 2 or 3; r is 0, 1 or 2; with the provisos that: at least one of m and r is not 0; the sum n+m+p+q+r+s is 7, 8, 9, 10, 11 , 12 or 13; the sum q+r+s is 2, 3, 4, 5 or 6 or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.

公开(公告)号：EP0486142B1

公开(公告)日：1995-12-20

申请号：EP91308936.3

申请日：1991-09-30

申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.

发明人： Mizuno, Naoko ,  Kai, Yoshiaki ,  Suzuki, Takashi

IPC分类号： C07C229/20 ,  C07C217/26 ,  G11B5/72

CPC分类号： G11B5/725 ,  C07C217/26 ,  C07C229/12 ,  Y10S428/90 ,  Y10T428/3154

公开(公告)号：EP3197945B1

公开(公告)日：2020-10-21

申请号：EP15845404.1

申请日：2015-09-18

申请人： 3M Innovative Properties Company

发明人： LAMANNA, William M. ,  BULINSKI, Michael J. ,  SMITH, Kiah A. ,  COSTELLO, Michael G. ,  TEVEROVSKIY, Georgiy

IPC分类号： C07D223/04 ,  C07C217/26 ,  C07D241/04 ,  C07D265/30 ,  C07D207/10 ,  C07D211/38 ,  C09K5/04 ,  C09K5/10 ,  C08J9/00 ,  C08J9/14

公开(公告)号：EP1885684B1

公开(公告)日：2011-07-13

申请号：EP06742964.7

申请日：2006-05-17

申请人： Almirall, S.A.

发明人： PUIG DURAN, Carlos ,  CRESPO CRESPO, Maria, Isabel ,  CASTRO PALOMINO LARIA, Julio, Cesar ,  GUAL ROIG, Silvia ,  NAVARRO ROMERO, Eloisa

IPC分类号： C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26 ,  C07D233/74 ,  A61K31/135 ,  A61K31/415 ,  A61K31/47 ,  A61P11/00

CPC分类号： C07D233/74 ,  C07C217/10 ,  C07C217/26 ,  C07C233/43 ,  C07C275/32 ,  C07D215/26

摘要： The present invention provides a compound of formula (I) wherein: R1 is a group selected from -CH2OH, -NHC(O)H and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH- wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2; R3 is selected from hydrogen and halogen atoms or groups selected from -SO-R5, -SO2- R5, -NH-CO-NH2, -CO-NH2, hydantoino, C1-4alkyl, C1-4alkoxy and -SO2NR5R6; R4 is selected from hydrogen atoms, halogen atoms and C1-4alkyl groups; R5 is a C1-4alkyl group or C3-8 cycloalkyl; R6 is independently selected from hydrogen atoms and C1-4alkyl groups; n, p and q are independently 0, 1 , 2, 3 or 4; m and s are independently 0, 1 , 2 or 3; r is 0, 1 or 2; with the provisos that: at least one of m and r is not 0; the sum n+m+p+q+r+s is 7, 8, 9, 10, 11 , 12 or 13; the sum q+r+s is 2, 3, 4, 5 or 6 or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.