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    DERIVES SATURES ET INSATURES DE L'ABIETANE, CONJUGUES DERIVES ET UTILISATIONS DANS UNE COMPOSITION DIAGNOSTIQUE, UN REACTIF ET UN DISPOSITIF
    1.
    发明公开
    DERIVES SATURES ET INSATURES DE L'ABIETANE, CONJUGUES DERIVES ET UTILISATIONS DANS UNE COMPOSITION DIAGNOSTIQUE, UN REACTIF ET UN DISPOSITIF 审中-公开
    饱和和非饱和松香衍生物及其变化和它们在诊断组合物，活性和设备

    公开(公告)号：EP1100773A1

    公开(公告)日：2001-05-23

    申请号：EP99932981.6

    申请日：1999-07-27

    申请人： BIOMERIEUX

    发明人： CHARLES, Marie-Hélène ,  PIGA, Nadia ,  BATTAIL-POIROT, Nicole ,  VERON, Laurent ,  DELAIR, Thierry ,  MANDRAND, Bernard

    IPC分类号： C07C243/36 ,  C07D207/46 ,  C07K5/06 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/58

    CPC分类号： G01N33/5308 ,  A61K47/6843 ,  C07K5/06026

    摘要： The invention concerns a saturated or unsaturated abietane derivative of general formula (I) wherein: Z is selected among -COOR?5, -CONR1R2¿, -COONR?3R4, -COR6¿, -CON, -COOR5, -CHOHR?7, -SR8, -OR8¿, -CN, -CNO, -CNS, -NCO, -NCS, -R1R2CR9; wherein R?1, R2, R3 and R4¿ represent a hydrogen atom, a C¿1?-C10 alkyl, a C6-C20 aryl optionally substituted; a C7-C10 alkene; a C1-C10 alkyne; an aminoacyl or peptidyl optionally substituted; or R?1 and R2 or R3 and R4¿ together can form a cycle or a heterocycle; R5 represents a hydrogen, a C¿1?-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne; an aryl, optionally substituted into C6-C20; R?6¿ represents a hydrogen, a halogen, a C¿1?-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne, an aryl optionally substituted into C6-C20; R?7¿ represents a hydrogen, a C¿1?-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne; R?8¿ represents a hydrogen, a C¿1?-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne; and R?9¿ is selected among -CN, -CNO, -CNS, -NCO, and -NCS. The invention also concerns a derived conjugate and the use of said derivative and said conjugate in a diagnostic composition, a reagent and a device.

    HOMOBIFUNCTIONAL AGENTS FOR COUPLING ENZYMES AND THE LIKE TO ANTIBODIES AND THE LIKE.
    10.
    发明公开
    HOMOBIFUNCTIONAL AGENTS FOR COUPLING ENZYMES AND THE LIKE TO ANTIBODIES AND THE LIKE. 失效
    同双功能剂离合器酶及其联合国模拟抗体及其类似物。

    公开(公告)号：EP0555336A4

    公开(公告)日：1994-10-12

    申请号：EP91920049

    申请日：1991-10-18

    申请人： ABBOTT LAB

    发明人： BIENIARZ CHRISTOPHER ,  WELCH CHRISTOPHER

    IPC分类号： C07D207/46 ,  C07C233/34 ,  C07C243/28 ,  C07C243/36 ,  C07C275/14 ,  C07D207/452 ,  C07D403/12 ,  C07K1/113 ,  C07K1/22 ,  C07K14/00 ,  C07K14/47 ,  C07K17/06 ,  C07K19/00 ,  C12N11/06 ,  G01N33/53 ,  G01N33/532 ,  G01N33/543 ,  G01N33/547 ,  G01N33/82 ,  G01N33/567 ,  C07C243/24 ,  C07D207/40 ,  C07D207/444

    CPC分类号： C12N11/06 ,  C07K14/47 ,  G01N33/54353 ,  G01N33/82

    摘要： A coupling agent useful in conducting immunoassays, particularly assays for B12, is disclosed. The coupling agent has formula (I) where Z and Z' can be the same or different, and each is H2NHN, ICH2, (a) or (b); k, m and n are integers from 1 to 10, X is an alkylene group, a cycloalkylene group, an alkylcycloalkylene group, a bivalent aromatic group, or an aminoalkylene group, R and R' can be the same or different, and each is a substituted or unsubstituted aminoalkylene group having from 1 to 10 carbon atoms or a cycloalkylene or alkylcycloalkylene group having from 5 to 20 carbon atoms. Z and Z' are the same except that they can be the same or different when both are (c). A method for purifying an aqueous intrinsic factor solution which contains R-protein is disclosed. The method involves adding to the intrinsic factor solution an amount of cobinamide sufficient to bind substantially all of the R-protein in the solution and an amount of an intrinsic factor affinity resin sufficient to bind the intrinsic factor in the solution, washing the bound cobinamide and the R-protein from the resin, eluting the intrinsic factor from the resin, and dialyzing the eluted intrinsic factor. The purified intrinsic factor can contain less than 0.004 percent cross reactivity with cobinamides, and at least 95 percent of the proteins in the purified material can bind cobalamins. A conjugate where microparticles and the purified intrinsic factor are conjugated by a moiety from one of the foregoing coupling agents is also disclosed, as is a kit for conducting an assay for cobalamins which includes the conjugate of microparticles and purified intrinsic factor. A method for conducting an assay for cobalamins, which method involves the use of the conjugate of microparticles and purified intrinsic factor is also disclosed.