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    PROCESS FOR PRODUCING HALOGENOALKYLSULFONAMIDE DERIVATIVES
    4.
    发明公开
    PROCESS FOR PRODUCING HALOGENOALKYLSULFONAMIDE DERIVATIVES 失效
    VERFAHREN ZUR HERSTELLUNG VON HALOGENALKYLSULFONAMID-DERIVATEN

    公开(公告)号：EP1020437A1

    公开(公告)日：2000-07-19

    申请号：EP98911045.7

    申请日：1998-03-26

    Applicant: Azwell Inc.

    Inventor： KASHIMA, Kenichi ,  SAKAMOTO, Yasuhiko ,  TAKEMURA, Shigetaka, Riverside Shirokita 35-610

    IPC: C07C311/02 ,  C07C303/38 ,  C07C309/80 ,  C07C303/02

    CPC classification number: C07C303/38 ,  C07C309/80 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C311/02 ,  C07C311/03 ,  C07C311/04 ,  C07C311/07

    Abstract: A process for preparing a halogenoalkylsulfonamide derivative represented by the general formula (I):
    wherein R 1 is alkyl, hydroxyalkyl, cycloalkyl, or phenyl which may have alkyl, alkoxy, halogen, hydroxyl, trifluoromethyl, nitro and amino; R 2 is hydrogen atom, alkyl, hydroxyalkyl, cycloalkyl, or phenyl which may have alkyl, alkoxy, halogen, hydroxyl, trifluoromethyl, nitro and amino; X is chlorine, bromine or iodine; and Y is alkylene group having 5 to 12 carbon atoms; an intermediate; and a process for preparing the intermediate. The amide derivative is a useful compound as an intermediate for preparing a diazacycloalkanealkylsulfonamide derivative, which has antiallergic activity and thereby is useful as a medicament for preventing and treating diseases such as bronchial asthma, allergic rhinitis, atopic dermatitis, urticaria, and the like.

    Abstract translation: 一种制备由通式（I）表示的卤代烷基磺酰胺衍生物的方法：其中R 1为可具有烷基，烷氧基，卤素，羟基，三氟甲基，硝基和氨基的烷基，羟基烷基，环烷基或苯基; R 2是氢原子，可以具有烷基，烷氧基，卤素，羟基，三氟甲基，硝基和氨基的烷基，羟基烷基，环烷基或苯基; X是氯，溴或碘; Y为碳原子数5〜12的亚烷基。 中间人 和中间体的制备方法。 酰胺衍生物是制备具有抗过敏活性的二氮杂环烷烷基磺酰胺衍生物的中间体的有用化合物，因此可用作预防和治疗诸如支气管哮喘，过敏性鼻炎，特应性皮炎，荨麻疹等疾病的药物。

    Process for the preparation of fluorooxy-fluorosulfonyl compounds by direct fluorination of fluoro-beta-sultones
    5.
    发明公开
    Process for the preparation of fluorooxy-fluorosulfonyl compounds by direct fluorination of fluoro-beta-sultones 失效
    Verfahren zur Herstellung von Fluor-oxy-fluorsulfonylverbindungen durch direkte Fluorierung von Fluor-β-sultonen。

    公开(公告)号：EP0384261A1

    公开(公告)日：1990-08-29

    申请号：EP90102714.4

    申请日：1990-02-12

    Applicant: AUSIMONT S.p.A.

    Inventor： Marraccini, Antonio, Dr. ,  Perego, Gabriele, Dr.

    IPC: C07C309/80 ,  C07C303/02

    CPC classification number: C07C303/02 ,  C07C309/80

    Abstract: Described is the preparation of fluorooxy-fluorosulfonyl com­pounds by direct fluorination of β-sultones with elemental fluorine according to the reaction scheme:
    wherein
    R₁ and R₂, the same or different from each other, represent fluorine or chlorine or an alkyl radical partial­ly or completely halogenated with fluorine and/or chlorine.
    The reaction is conducted continuously in the presence of a fluorination catalyst, preferably an alkali-metal fluoride, at temperatures of from -40°C to +100°C and at pressures of from 50 to 800 kPa.

    Abstract translation: 描述了根据反应方案，用元素氟直接氟化β-磺内酯的氟代氧氟代磺酰化合物的制备方法：其中R 1和R 2彼此相同或不同，表示氟或氯或烷基部分 或用氟和/或氯完全卤化。 在-40℃至+ 100℃的温度和50至800kPa的压力下，在氟化催化剂，优选碱金属氟化物的存在下，连续进行反应。

    IMPROVED PROCESS FOR THE SULFOCHLORINATION OF HYDROCARBONS
    8.
    发明公开
    IMPROVED PROCESS FOR THE SULFOCHLORINATION OF HYDROCARBONS 审中-公开
    改进方法sulphochlorinating烃

    公开(公告)号：EP2459523A2

    公开(公告)日：2012-06-06

    申请号：EP10745041.3

    申请日：2010-07-28

    Applicant: Dow Global Technologies LLC

    Inventor： HIRSEKORN, Kurt, F. ,  TENN, William ,  NICKIAS, Peter, N.

    IPC: C07C303/10 ,  C07C309/80

    CPC classification number: C07C303/10 ,  C07C309/80

    Abstract: Produce a sulfo-chlorinated hydrocarbon using liquid sulfur dioxide, a chlorinating agent such as chlorine or sulfuryl chloride, and a metal complex catalyst, the catalyst being represented as LnM where L is at least one of an amine, phosphine, chloride or oxide, n is an integer within a range of from 1 to 6, and M is a metal selected from a group consisting of copper (Cu), ruthenium (Ru), iron (Fe), chromium (Cr), lanthanum (La), nickel (Ni), palladium (Pd), rhodium (Rh), rhenium (Re), molybdenum (Mo) and manganese (Mn).

    PROCEDE DE SYNTHESE DE DERIVES A RADICAL HYDROGENOFLUOROMETHYLENESULFONYLE
    9.
    发明公开
    PROCEDE DE SYNTHESE DE DERIVES A RADICAL HYDROGENOFLUOROMETHYLENESULFONYLE 有权
    PROCEDE DE SYNTHES DE衍生自由基氢芴甲基烯丙基砜

    公开(公告)号：EP1517888A2

    公开(公告)日：2005-03-30

    申请号：EP03761633.1

    申请日：2003-06-24

    Applicant: RHODIA CHIMIE

    Inventor： SAINT-JALMES, Laurent

    IPC: C07C319/14 ,  C07C323/03 ,  C07C303/16 ,  C07C309/80

    CPC classification number: C07C319/14 ,  C07C303/16 ,  C07C323/03 ,  C07C309/80

    Abstract: The invention concerns a method for synthesis of hydrogenofluoromethylenesulphonyl radical derivatives, comprising: a) a step which consists in condensing a thiolate (that is a monoalkyl sulphide salt) with a compound having a sp3 hybridized carbon bearing a hydrogen, a fluorine, a heavy halogen selected among chlorine, bromine and iodine and an electron-attracting group selected among fluorine and those whereof the σp is not less than 0.2, advantageously than 0.4; b) a step which consists in oxidizing the compound obtained in step a). The invention is applicable to the synthesis of various compounds having a suphinyl or sulphonyl group.

    Abstract translation: 本发明涉及一种用于合成氢氟代亚甲基磺酰基自由基衍生物的方法，其包括：a）将硫醇盐（即单烷基硫化物盐）与具有sp3杂化碳的化合物缩合的步骤，该化合物带有氢，氟，重卤素 选自氯，溴和碘以及选自氟和其中σp不小于0.2，有利地小于0.4的那些吸电子基团; b）包括氧化步骤a）中获得的化合物的步骤。 本发明适用于合成具有亚磺酰基或磺酰基的各种化合物。

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