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    TRACHEAL SMOOTH MUSCLE RELAXANT
    4.
    发明公开
    TRACHEAL SMOOTH MUSCLE RELAXANT 失效
    RELAXANSFÜRDIE GLATTELUFTRÖHRENMUSKULATUR

    公开(公告)号：EP0885610A4

    公开(公告)日：1999-04-21

    申请号：EP97900460

    申请日：1997-01-20

    申请人： NIPPON SUISAN KAISHA LTD

    发明人： YAMASHITA SHINYA ,  TAKEO JIRO ,  JINNO SHUJI ,  KOGURE YASUYO ,  ONUKI HIROYUKI ,  OKITA TAKAAKI ,  HATA JUNICHIRO ,  FUKUDA YASUHIRO ,  OHTSUKA NAOMI

    IPC分类号： A61K31/352 ,  A61K31/382 ,  C07D313/14 ,  C07D337/14 ,  A61K31/335 ,  A61K31/38 ,  C07D337/16

    CPC分类号： C07D337/14 ,  A61K31/352 ,  A61K31/382 ,  C07D313/14 ,  Y10S514/826

    摘要： A tracheal smooth muscle relaxant characterized by comprising as the active ingredient a compound represented by general formula (1) or a pharmacologically acceptable salt thereof; wherein when X and Y are bonded through a single bond, then X and Y each independently represents any member selected from the group consisting of CH2, CHW1 (where W1 represents halogeno, hydroxy, or lower alkoxy), and C=O, while when X and Y are bonded through a double bond, then X and Y each independently represents any member selected from the group consisting of CH and COW2 (where W2 represents lower alkyl or lower alkylcarbony); Z represents O, S, S=O, or SO¿2?; and R?1 to R8¿ each represents member selected from the group consisting of hydrogen, VR9 (where V represents O, S, S=O, or SO¿2?, and R?9¿ represents hydrogen, lower alkyl, lower hydroxyalkyl, lower acyl, trihalomethyl, or lower carboxyalkyl), lower carboxyalkyl, lower hydroxyalkyl, lower hydroxyalkenyl, lower hydroxyalkynyl, halogeno, lower alkyl, lower alkyl ketone, trihalomethyl, trimethylsilylethynyl, nitro, amino, lower N-carbonylalkyl, lower alkylphenyl, and phenyl.

    摘要翻译： 本发明提供含有下述式（1）表示的化合物或其药理学可接受的盐作为有效成分的气管平滑肌松弛剂。 在该式中，X和Y各自为选自CH 2，CHW 1（其中W 1为卤素原子，羟基或低级烷氧基）和C = O的任何基团，当键 的X和Y是单键，而当它是双键时，X和Y各自是选自CH和COW 2的任何基团（其中W 2是低级烷基或低级烷基羰基 ）; Z是O，S，S = O或SO 2; R 1和R 3各自选自氢原子，VR 9（其中V为O，S，S = O或SO 2; R 9为氢原子，低级烷基 羟基低级烷基，低级酰基，三卤代甲基或羧基低级烷基），羧基低级烷基，羟基低级烷基，羟基低级烯基，羟基低级炔基，卤素原子，低级烷基，低级烷基酮 三卤代甲基，三甲基甲硅烷基乙炔基，硝基，氨基，N-羰基低级烷基，低级烷基苯基和苯基。