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公开(公告)号：EP3426642A1
公开(公告)日：2019-01-16
申请号：EP17764089.3
申请日：2017-03-09
IPC分类号： C07D253/10 , C07F9/38 , C07F9/48
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公开(公告)号：EP1799656A1
公开(公告)日：2007-06-27
申请号：EP05792421.9
申请日：2005-08-24
申请人： Targegen, Inc.
IPC分类号： C07D253/10
CPC分类号： A61K31/506 , A61K31/4439 , A61K31/501 , A61K45/06 , C07D213/65 , C07D239/48 , C07D253/06 , C07D271/113 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
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公开(公告)号：EP1773791A1
公开(公告)日：2007-04-18
申请号：EP05763768.8
申请日：2005-06-22
发明人： GAVAI, Ashvinikumar, V. , MASTALERZ, Harold , DARIS, Jean-Paul , DEXTRAZE, Pierre , LAPOINTE, Philippe , RUEDIGER, Edward, H. , VYAS, Dolatrai, M. , ZHANG, Guifen
IPC分类号： C07D253/10 , A61K31/53 , A61P35/00 , A61P35/04
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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4.发明公开PROCESS FOR PREPARING 3-AMINO-1,2,4-BENZOTRIAZINE DIOXIDE 失效VERFAHREN ZUR HERSTELLUNG VON 3-AMINO-1,2,4--BENZOTRIAZINDIOXIDE
公开(公告)号：EP0865435A4
公开(公告)日：1998-12-23
申请号：EP96941445
申请日：1996-11-21
申请人： SANOFI SA
发明人： PHILION RICHARD E
IPC分类号： C07D253/06 , C07D253/10 , C07D253/065
CPC分类号： C07D253/10
摘要： Process of producing 3-amino-1,2,4-benzotriazine 1,4-dioxide by reacting benzofurazan-1 oxide with disodiumcyanamide under homogeneous conditions followed by allowing crystallization to occur in a buffered solution. In a preferred embodiment, the process comprises reacting benzofurazan-1 oxide with cyanamide and sodium hydroxide under homogeneous conditions followed by purification in a mixture of acetone and acetic acid.
摘要翻译： 通过在均相条件下使苯并呋咱-1氧化物与二氰基氰胺反应制备3-氨基-1,2,4-苯并三嗪1,4-二氧化物的方法，随后在缓冲溶液中进行结晶。 在一个优选的实施方案中，该方法包括在均相条件下使苯并呋咱-1氧化物与氰胺和氢氧化钠反应，然后在丙酮和乙酸的混合物中纯化。
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5.发明公开NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS 审中-公开作为S-硝基糖基还原酶还原酶抑制剂的新型取代的双环芳香族化合物
公开(公告)号：EP2651871A4
公开(公告)日：2015-07-22
申请号：EP11849550
申请日：2011-12-16
发明人： SUN XICHENG , QIU JIAN , STOUT ADAM
IPC分类号： C07C65/24 , A61K31/216 , A61P11/06 , C07C65/105 , C07D213/79 , C07D215/06 , C07D215/20 , C07D217/16 , C07D239/28 , C07D253/10 , C07D401/04 , C07D401/10 , C07D405/04 , C07D409/14
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
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6.发明授权
公开(公告)号：EP2038263B1
公开(公告)日：2014-03-05
申请号：EP07787011.1
申请日：2007-07-03
发明人： ADLER, Jürgen , KANITZ, Andreas
IPC分类号： C07D253/10 , C07D403/06 , C07D403/14 , C07D487/04 , C07D519/00 , H01L31/00
CPC分类号： C07D403/14 , C07D403/06 , C07D487/04 , C07D519/00 , Y10S428/917
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7.发明授权TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS 有权三环1,2,4- TRIAZINOXIDE和用于治疗应用在癌症治疗有成分
公开(公告)号：EP1866292B1
公开(公告)日：2010-12-15
申请号：EP06733153.8
申请日：2006-03-31
发明人： HAY, Michael, Patrick , BLASER, Adrian , DENNY, William, Alexander , HICKS, Kevin, Owen , LEE, Ho, Huat , PCHALEK, Karin , PRUIJN, Frederik, Bastiaan , SIIM, Bronwyn, Gae , WILSON, William, Robert , YANG, Shangjin
IPC分类号： C07D253/10 , C07D403/12 , C07D401/12 , C07D413/12 , C07D403/06 , C07D491/048 , C07D491/056 , C07D491/052 , C07D487/04 , C07D471/04 , A61K31/53 , A61P35/00
CPC分类号： C07D253/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056
摘要： The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula: (I); and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
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公开(公告)号：EP1761268A4
公开(公告)日：2009-07-08
申请号：EP05791275
申请日：2005-06-28
发明人： BORZILLERI ROBERT M , CHEN ZHONG , HUNT JOHN T , HUYNH TRAM N , POSS MICHAEL A , SCHROEDER GRETCHEN M , VACCARO WAYNE , WONG TAI W , CHEN XIAO TAO , KIM KYOUNG S
IPC分类号： A61K31/53 , A61K31/519 , A61K31/52 , A61P19/02 , A61P35/00 , C07D253/10 , C07D471/04 , C07D473/14 , C07D487/02 , C07D487/04 , C07D495/04
CPC分类号： C07D471/04 , C07D473/00 , C07D473/30 , C07D487/04 , C07D495/04
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9.发明授权ARYL KETONE PYRROLO-TRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权作为激酶抑制剂SUITABLE ARYLKETONPYRROLOTRIAZIN CONNECTIONS
公开(公告)号：EP1503996B1
公开(公告)日：2008-12-24
申请号：EP03718493.4
申请日：2003-04-18
IPC分类号： C07D253/10 , C07D401/06 , C07D403/06 , A61K31/53 , A61P11/00 , A61P17/06 , A61P19/02 , A61P19/08
CPC分类号： C07D487/04
摘要： Compounds having the formula (I), [chemical structure] and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are surprisingly advantageous as p38 kinase inhibitors, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, NH2, or NH(CH3), preferably methyl; X is N or CH; and R1 through R6 are as described in the specification.
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10.发明公开SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权对于Hyper增殖疾病和与血管发生SUITABLE相关疾病的治疗取代的4- AMINOPYRROLOTRIAZINDERIVATE
公开(公告)号：EP1957485A2
公开(公告)日：2008-08-20
申请号：EP06838828.9
申请日：2006-12-01
发明人： DIXON, Julie , PHILLIPS, Barton , ACHEBE, Furahi , KLUENDER, Harold , NEWCOM, Jason , PARCELLA, Kyle , O'CONNOR, Stephen J. , MAGNUSON, Steven , HONG, Zhenqiu , ZHANG, Zhonghua , LIU, Zheng , KHIRE, Uday , WANG, Lei , MICHELS, Martin , CHANDLER, Brent
IPC分类号： C07D417/06 , C07D413/06 , C07D267/10 , C07D253/10 , A61K31/541 , A61K31/553 , A61K31/5377 , A61K31/53 , C07D213/75 , C07D207/50 , A61K31/40 , A61K31/44
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
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