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    OPTICAL SYSTEM FOR THE DIGITAL IMAGING OF UNSTAINED TISSUE SAMPLES AND METHOD THEREOF
    1.
    发明公开
    OPTICAL SYSTEM FOR THE DIGITAL IMAGING OF UNSTAINED TISSUE SAMPLES AND METHOD THEREOF 审中-公开

    公开(公告)号：EP4414766A1

    公开(公告)日：2024-08-14

    申请号：EP23155716.6

    申请日：2023-02-09

    申请人： Siemens Healthineers AG

    发明人： Dethlefsen, Mark ,  Engel, Thomas ,  Marquardt, Gaby

    IPC分类号： G02B21/10 ,  G02B21/16 ,  G02B21/36

    CPC分类号： G02B21/362 ,  G02B21/367 ,  G02B21/16 ,  G02B21/10

    摘要： An optical system for the digital imaging of unstained tissue samples, comprising: a first illumination source unit, configured to illuminate an unstained tissue sample with light sources, each defining a different light incidence angle with respect to the unstained tissue sample, wherein the wavelengths of the light sources are adapted to produce fluorescence of at least parts of the unstained tissue sample; a microscope, comprising at least an objective and a light detector, wherein the light detector is configured to receive the light emitted from the illuminated unstained tissue sample, wherein the first illumination source unit is located between the unstained tissue sample and the objective of the microscope; and a Fourier Ptychography unit, configured to generate, based on the light received by the light detector, a corresponding digital image of the unstained tissue sample with a first field of view by deploying Fourier Ptychography Microscopy.

    DARK FIELD ILLUMINATOR FOR MICROSCOPY IMAGING
    4.
    发明公开
    DARK FIELD ILLUMINATOR FOR MICROSCOPY IMAGING 审中-公开

    公开(公告)号：EP3951471A1

    公开(公告)日：2022-02-09

    申请号：EP21755346.0

    申请日：2021-01-07

    申请人： Convergence Technology Co. Ltd.

    发明人： HU, Qinglei ,  HUANG, Kai ,  LI, Ning ,  LI, Mengting ,  DING, Changjie

    IPC分类号： G02B21/10

    摘要： The present invention discloses a dark field illuminator for microscopic imaging, characterized in that, the dark field illuminator is arranged above an adjustable lens group of a unit microscopic imaging module and corresponds to the adjustable lens group, a surface of the dark field illuminator is attached to a back of a sample slide, and the sample slide is located between the dark field illuminator and the adjustable lens group; the dark field illuminator includes a bright and dark field substrate 4017 and a dark field black background patch 4018, the size of the dark field black background patch matches with that of the adjustable lens group, and the dark field black background patch is arranged close to or away from the adjustable lens group relatively to the bright and dark field substrate. Preferably, the bright and dark field substrate further has a recessed structure with a white diffuse reflection surface. The dark field illumine does not have a light source itself, which reduces a volume, and preferably, the dark field illuminator for microscopic imaging also has a bright field illumination structure and function, which can also be used as dark/bright field illumination alone, and can also be used for switching, so that the quick switching between bright and dark fields realizes integration and miniaturization of dark field illuminators and bright field illuminators.

    VORRICHTUNG UND VERFAHREN ZUR BILDAUFNAHME
    8.
    发明公开
    VORRICHTUNG UND VERFAHREN ZUR BILDAUFNAHME 审中-公开

    公开(公告)号：EP3394656A2

    公开(公告)日：2018-10-31

    申请号：EP16825751.7

    申请日：2016-12-22

    申请人： Carl Zeiss Microscopy GmbH

    发明人： GAIDUK, Alexander ,  STICKER, Markus ,  STOPPE, Lars ,  WOLLESCHENSKY, Ralf

    IPC分类号： G02B21/08 ,  G02B21/10

    CPC分类号： G02B21/084 ,  G02B21/10 ,  G02B21/125

    摘要： A device for capturing images is provided in which an image-capturing device (14) and an illumination device (13) are arranged on the same side of a sample plane (11). The image-capturing device (13) has illumination portions which can be controlled independently of each other, for example individual light sources, in order to make it possible for the sample (12) in the sample plane (11) to be illuminated at different angles and/or from different directions. In this way, a plurality of images can be captured with different illumination situations which can be combined into a resulting image having improved properties.

    VERFAHREN UND VORRICHTUNG ZUM UNTERSUCHEN EINER PROBE MIT EINER STRUKTURIERETEN LICHTBLATTBELEUCHTUNG
    9.
    发明公开
    VERFAHREN UND VORRICHTUNG ZUM UNTERSUCHEN EINER PROBE MIT EINER STRUKTURIERETEN LICHTBLATTBELEUCHTUNG 审中-公开

    公开(公告)号：EP3359997A1

    公开(公告)日：2018-08-15

    申请号：EP16778396.8

    申请日：2016-10-10

    申请人： Leica Microsystems CMS GmbH

    发明人： FAHRBACH, Florian ,  KNEBEL, Werner

    IPC分类号： G02B21/10 ,  G02B21/16 ,  G02B21/36 ,  G02B27/58

    CPC分类号： G02B21/16 ,  G02B21/10 ,  G02B21/367 ,  G02B27/58

    摘要： The invention relates to a method and an apparatus for microscopic examination of a sample (24). The method contains the step of producing an illumination light beam (2) using a light source, the step of spatially splitting the illumination light beam (2) into at least two partial illumination light beams (3, 4) using a splitting means (1), the step of guiding the partial illumination light beams (3, 4) through an illumination objective (7) common to both partial illumination light beams (3, 4), the step of deflecting at least one of the partial illumination light beams (3, 4) after these have passed through the illumination objective (7) using at least one deflection means (29) in such a way that the partial illumination light beams (3, 4) interfere with one another in an illumination plane (11) such that an illumination pattern (12) arises in the illumination plane (11), and the step of producing an image of a sample region illuminated by the illumination pattern (12), wherein the detection light emanating from the sample region reaches a spatially resolving detector through a detection objective (8).