公开(公告)号：EP3530270B1

公开(公告)日：2024-08-07

申请号：EP17861843.5

申请日：2017-10-12

IPC分类号： A61K31/191 ,  A23L33/12 ,  A61P37/06 ,  A61P37/04 ,  A61P37/02 ,  A61P31/14 ,  A61K39/39 ,  A61K31/231 ,  A61K31/194 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61P37/02 ,  A23L33/12 ,  A61P37/06 ,  A61K31/191 ,  A61K31/231 ,  A61P37/04 ,  A61K31/194 ,  A61K39/39 ,  A61K2039/54120130101 ,  A61K2039/5551120130101 ,  A61P31/14 ,  C12N2770/3263420130101 ,  C12N2760/1613420130101 ,  A61K39/12 ,  Y02A50/30

公开(公告)号：EP3917525B1

公开(公告)日：2024-02-28

申请号：EP20702766.5

申请日：2020-01-28

发明人： THOR, Dominik

IPC分类号： A61K31/4412 ,  A61K8/49 ,  A61K8/365 ,  A61K8/42 ,  A61P17/14 ,  A61Q7/00 ,  A61K31/16 ,  A61K31/191 ,  A61K31/4196 ,  A61K31/444

公开(公告)号：EP3893862B1

公开(公告)日：2023-11-22

申请号：EP18942897.2

申请日：2018-12-14

发明人： CHEN, Yih-Sharng ,  SHEN, Li-Jiuan ,  LIN, Mei-Hsin ,  CHOU, Heng-Wen

IPC分类号： A61K31/16 ,  A61K31/255 ,  A61K31/4418 ,  A61P41/00 ,  A61K31/167 ,  A61K31/047 ,  A61K31/19 ,  A61K33/00 ,  A61K33/04 ,  A61K33/06 ,  A61K33/14 ,  A61K31/191

公开(公告)号：EP4230201A1

公开(公告)日：2023-08-23

申请号：EP22166594.6

申请日：2022-04-04

申请人： UNIVERSIDADE NOVA DE LISBOA

发明人： GODINHO FERREIRA DIAS NUNES DOS SANTOS, MARIA C. ,  CARREGOSA, DIOGO MIGUEL JOSÉ ,  MERCA SARAIVA MONTEIRO CARECHO, RAFAEL JOSÉ

IPC分类号： A61K31/255 ,  A61K31/191 ,  A61K31/192 ,  A61K31/216 ,  A61K31/235 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28

摘要： Through the past decades, several epidemiological studies have revealed that polyphenols-rich Mediterranean diet, comprising fruit and vegetables, can provide beneficial effects in humans, preventing neurodegenerative diseases and cognitive decline. After ingestion, polyphenols undergo extensive metabolization, generating a wide range of metabolites, identified as the effective bioactive molecules in human organism. Provided herein is a polyphenol metabolitebased composition for preventing and treating neurodegenerative diseases. Proof-of-principle for the latter concept is demonstrated by in vitro reduction in multiple cytokines production, usually associated to neuroinflammation and neurodegenerative diseases. The composition of the present invention can be used in nutraceutical and pharmaceutical formulations.

公开(公告)号：EP4147693A1

公开(公告)日：2023-03-15

申请号：EP22204653.4

申请日：2014-09-12

申请人： Replicon Health Oy

发明人： Hirvonen, Petteri ,  Eriksson, Peter ,  Kaksonen, Risto

IPC分类号： A61K31/19 ,  A61K31/191 ,  A61P43/00 ,  A61P3/00 ,  A23L33/10 ,  A61P1/16 ,  A61P1/18

摘要： The present invention relates to a composition comprising one or more compounds selected from the group consisting of D-glyceric acid, DL-glyceric acid, and salts thereof for use in a method of treating, alleviating or preventing a non-communicable or a chronic disease or disorder related directly or indirectly to mitochondrial degeneration and/or mitochondrial dysfunction, impaired cytosolic catabolism of carbohydrates, deteriorated antioxidant defenses, deteriorated inflammation control, and/or formation of malfunctioning proteins, wherein the disease or disorder is a disorder associated with metabolism, wherein the disorder associated with metabolism is selected from the group consisting of acute or chronic liver failure, acute or chronic renal failure, splenomegaly, acute or chronic pancreatic failure, and multi-organ dysfunction syndrome.

公开(公告)号：EP3959209A1

公开(公告)日：2022-03-02

申请号：EP20795605.3

申请日：2020-04-23

申请人： University Health Network

发明人： LI, Sze-wan ,  BRAY, Mark Robert

IPC分类号： C07D413/10 ,  A61K31/191 ,  A61K31/5377 ,  A61P35/00 ,  C07C57/15

公开(公告)号：EP3299011B1

公开(公告)日：2021-08-18

申请号：EP17192733.8

申请日：2017-09-22

发明人： Lee, Kyoung Lack ,  Kang, Si Ha

IPC分类号： A61K9/08 ,  A61K47/42 ,  A61K47/02 ,  A61K31/191 ,  A61K31/194 ,  A61K31/575 ,  A61K33/14 ,  A61K38/47 ,  A61P3/04

公开(公告)号：EP3848016A1

公开(公告)日：2021-07-14

申请号：EP20150645.8

申请日：2020-01-08

申请人： 3M Innovative Properties Company

发明人： Haeberlein, Ingo ,  Schmid, Brenda ,  Hauke, Melanie ,  Safi, Ajmal

IPC分类号： A61K8/36 ,  A61K8/365 ,  A61K31/19 ,  A61K31/191 ,  A61K31/20 ,  A61Q11/00

摘要： The invention relates to an oral care composition comprising certain fatty acid components or salts thereof. The fatty acid components are useful in a method of treating caries by reducing the lactic acid release of lactic acid releasing bacteria in an oral biofilm in the mouth of a human being or animal.
The fatty acid component comprises a carboxyl moiety which is attached to a C 3 to C 7 moiety to which optionally one or more residues selected from methyl, methoxy or hydroxy can be attached, and/or wherein one alky moiety of the C 3 to C 7 moiety is replaced by a keto moiety.
The invention also relates to a kit of parts comprising Part A comprising the fatty acid or component, Part B comprising water and/or a carrier component, and optionally Part C comprising an application device.

公开(公告)号：EP3037401B1

公开(公告)日：2020-05-06

申请号：EP15196120.8

申请日：2009-09-15

申请人： The Brigham and Women's Hospital, Inc.

发明人： Serhan, Charles ,  Yang, Rong

IPC分类号： C07C59/42 ,  A61K31/191 ,  C07D303/12 ,  A61K31/336 ,  A61P29/00 ,  A61P35/00 ,  A61K31/202 ,  A61K31/232 ,  C11C3/00

公开(公告)号：EP3597175A1

公开(公告)日：2020-01-22

申请号：EP18768646.4

申请日：2018-03-15

申请人： Ezaki Glico Co., Ltd.

发明人： TANAKA, Tomoko ,  KOBAYASHI, Takatsugu ,  ASAKUMA, Hiroki

IPC分类号： A61K8/73 ,  A23L33/10 ,  A23L33/16 ,  A23L33/18 ,  A61K8/21 ,  A61K8/365 ,  A61K8/64 ,  A61K31/191 ,  A61K31/7024 ,  A61K33/16 ,  A61K38/04 ,  A61K38/16 ,  A61P1/02 ,  A61Q11/00

摘要： The purpose of the present invention is to provide an oral composition that possesses an excellent teeth remineralization promoting effect and that is capable of effectively promoting teeth remineralization even when retained in the oral cavity for a short period of time. An oral composition in which (A) a calcium salt of organic acid, (B) a fluoride, and (C) a basic peptide and/or a basic protein in which 60% or more of the constituent amino acid residues are basic amino acid residues are added in combination is capable of dramatically promoting teeth remineralization as a result of a synergetic effect of these components and is capable of effectively promoting teeth remineralization even when retained in the oral cavity for a short period of time.