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    Uses of a novel Eimeria gene and corresponding protein
    8.
    发明公开
    Uses of a novel Eimeria gene and corresponding protein 审中-公开
    Verwendungen von einem neuen Eimeria Gen und entsprechender蛋白质

    公开(公告)号：EP2311859A1

    公开(公告)日：2011-04-20

    申请号：EP10176984.2

    申请日：2004-06-30

    申请人： Bayer Animal Health GmbH

    发明人： Greif, Dr. Gisela ,  Hosse, Ralf ,  Krücken, Dr. Jürgen ,  Wunderlich, Prof. Dr. Frank

    IPC分类号： C07K14/44 ,  A61K39/395 ,  A61K39/012

    CPC分类号： C07K16/20 ,  A61K39/012 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/455

    摘要： The invention relates to a novel oocyst sporocyst protein ( Et OS22) belonging to the parasite of the species Eimeria tenella and to the polynucleotide encoding this protein, to vectors which contain this polynucleotide, to cells which are transformed with these vectors, to antibodies which are directed against the protein, to vaccines which comprise the polynucleotide, the protein, or fragments thereof, the abovementioned vectors or antibodies directed against the protein, and to the use of polynucleotide or of polypeptide for finding active compounds for treating an infection with Eimeria and active compounds which are suitable for the therapy of an infection with Eimeria.

    摘要翻译： 本发明涉及属于艾美球虫种类的寄生虫和编码该蛋白质的多核苷酸的新型卵囊孢子囊蛋白（Et OS22）与含有该多核苷酸的载体对于用这些载体转化的细胞， 针对蛋白质的疫苗，涉及包含多核苷酸，蛋白质或其片段的疫苗，针对蛋白质的上述载体或抗体，以及多核苷酸或多肽用于寻找用于治疗艾美球虫感染和活性物质的活性化合物的用途 适用于艾美球虫感染治疗的化合物。

    Molecular identification of Aspergillus Species
    9.
    发明公开
    Molecular identification of Aspergillus Species 审中-公开
    Molekulare Identifizierung der Aspergillus-Species

    公开(公告)号：EP2108707A2

    公开(公告)日：2009-10-14

    申请号：EP09166867.3

    申请日：2003-05-16

    申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

    发明人： Morrison, Christine, J ,  Hinrikson, Hans, Peter

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  A61K39/00 ,  A61K39/012 ,  A61K39/35 ,  C12P19/34 ,  C12P21/06 ,  C07K1/00 ,  C12N15/11

    CPC分类号： C12Q1/6895

    摘要： Novel techniques for the detection of Aspergillus in samples are disclosed. These techniques relate to PCR amplification and/or detection of Aspergillus ITS1 rDNA sequences, and the identification of particular species of Aspergillus by detecting differences in the ITS1-V1, ITS-V2, ITS-V3, ITS-V4, and ITS-V5 nucleic acid sequences of Aspergillus . The highly variable regions of the ITS1 rDNA sequences are particularly useful in distinguishing, for example, Aspergillus clavatus, Aspergillus granulosus, Aspergillus sydowii, Aspergillus flavipes, Aspergillus restrictus, Aspergillus versicolor, Aspergillus wentii, and Aspergillus chevalieri . In particular embodiments, the sequence differences are also able to distinguish among variants of particular species, such as Aspergillus granulosus CBS 119.5A, Aspergillus granulosus strain NRRL 1932, Aspergillus sydowii strain NRRL 250, Aspergillus sydowii strain NRRL 4768, Aspergillus sydowii strain CUHI, Aspergillus sydowii strain CUH2, Aspergillus sydowii strain CUH7, and Aspergillus sydowii strain CUH8.

    摘要翻译： 公开了用于检测样品中曲霉菌的新技术。 这些技术涉及通过检测ITS1-V1，ITS-V2，ITS-V3，ITS-V4和ITS-V5核酸中的差异来鉴定曲霉ITS1 rDNA序列的PCR扩增和/或检测，并鉴定特定的曲霉种 曲霉酸序列。 ITS1 rDNA序列的高度可变区特别可用于区分例如曲霉菌（Aspergillus clavatus），米曲霉（Aspergillus granulosus），曲霉（Aspergillus sydowii），曲霉（Aspergillus flavipes），曲霉（Aspergillus restrictionus），曲霉（Aspergillus versicolor），曲霉（Aspergillus goii）和赭曲霉（Aspergillus chevalieri）。 在特定实施方案中，序列差异也能够区分特定种类的变体，例如颗粒细菌菌丝CBS 119.5A，粒细菌菌株NRRL 1932，曲霉菌菌株NRRL 250，曲霉菌菌株NRRL 4768，曲霉菌菌株CUHI，曲霉属（Aspergillus sydowii） sydowii菌株CUH2，曲霉菌菌株CUH7和曲霉菌菌株CUH8。