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1.发明公开
公开(公告)号：EP4450084A1
公开(公告)日：2024-10-23
申请号：EP23382365.7
申请日：2023-04-19
IPC分类号： A61K39/12 , A61K39/008 , A61P31/14 , A61P33/02 , A61K39/00
摘要： The present invention refers to a pharmaceutical composition (from hereinafter pharmaceutical composition of the invention), preferably a vaccine composition, comprising a lipid-based nanoparticle and optionally an excipient, wherein the lipid-based nanoparticle comprises the large extracellular loop (LEL) of CD9 of SEQ ID NO 2 displayed on its surface or an amino acid sequence having at least 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identity to SEQ ID NO 2 displayed on its surface. That is, the large extracellular loop (LEL) of CD9 of SEQ ID NO 2, or a sequence having the indicated sequence identity, is associated with or displayed on the exterior surface of the lipid nanoparticle.
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公开(公告)号：EP4373579A1
公开(公告)日：2024-05-29
申请号：EP22754840.1
申请日：2022-07-20
发明人： HAN, Yao , CHAI, Xianfeng , LIU, Juan , LUO, Qiuhong , MEHRLING, Thomas
IPC分类号： A61P33/02 , C07D487/04
CPC分类号： C07D487/04 , A61P33/02
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公开(公告)号：EP4349855A1
公开(公告)日：2024-04-10
申请号：EP22809977.6
申请日：2022-05-03
发明人： GAZZINELLI, Ricardo, Tostes , CASTRO, Júlia, Teixeira, de , JUNQUEIRA, Caroline, Furtado , TEIXEIRA, Santuza, Maria, Ribeiro , FERNANDES, Ana, Paula, Salles, Moura
IPC分类号： C07K14/44 , A61K39/005 , A61P33/02
摘要： The present invention relates to a recombinant chimeric protein containing immunogenic regions from the trans-sialidase (TS) protein and amastigote surface protein-2 (ASP-2) from Trypanosoma cruzi and a composition containing said protein that displayed vaccine potential in a murine model. The invention also comprises the use of the chimeric protein for manufacturing vaccines.
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公开(公告)号：EP4324524A2
公开(公告)日：2024-02-21
申请号：EP23208555.5
申请日：2011-06-30
IPC分类号： A61P33/02
摘要： The invention relates to solid pharmaceutical or veterinary compositions comprising
substantially pure Tulythromycin A in form of an addition salt with one or more acids, and to methods for preparing them. Following reconstitution with an aqueous solvent, the resulting solutions of Tulathromycin A may be administering to a mammal in order to treat bacterial or protozoal infections.-
公开(公告)号：EP3744723B1
公开(公告)日：2023-10-18
申请号：EP19743399.8
申请日：2019-01-23
发明人： WANG, Yihan , ZHAO, Jiuyang
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00 , A61P25/00 , A61P33/02 , C07D471/22
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公开(公告)号：EP4248948A1
公开(公告)日：2023-09-27
申请号：EP21887931.0
申请日：2021-11-08
发明人： RABELLO, Ana, Lúcia, Teles , COSTA, Jorge, Carlos, Santos da , QUEIROZ, Dinalva, Brito de , TEIXEIRA, Eliane, de Morais
IPC分类号： A61K9/107 , A61K31/7036 , A61K31/7048 , A61K31/138 , A61K33/24 , A61P33/02
摘要： The drugs available for the treatment of cutaneous leishmaniasis have unsatisfactory efficacy, frequent and serious adverse effects, and require long treatment regimens. Thus, the search for new treatment alternatives for cutaneous leishmaniasis is considered a priority by the World Health Organization. Parenteral administration of pentavalent antimonials for the treatment of all forms of leishmaniasis, including cutaneous leishmaniasis, has several limitations. The therapy is long, requires repeated doses, and adverse reactions are frequent. Topical treatment is an attractive alternative for cutaneous leishmaniasis, offering significant advantages over systemic therapy: fewer adverse effects, ease of administration, and lower costs. The present inventors aimed to provide a fixed-dose topical composition containing at least one antileishmanial compound, providing adequate absorption of the active ingredient. Another objective of the present invention is to provide a topical, fixed-dose formulation containing a combination of antileishmanial compounds that has sufficient efficacy and safety to be used in the treatment of cutaneous leishmaniasis.
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公开(公告)号：EP4178587A1
公开(公告)日：2023-05-17
申请号：EP21759383.9
申请日：2021-07-13
申请人： Adifeed SP. z o. o.
发明人： IWINSKI, Hubert , ROZANSKI, Henryk
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公开(公告)号：EP4176717A1
公开(公告)日：2023-05-10
申请号：EP21831706.3
申请日：2021-07-02
发明人： FUJIHARA, Hirokazu , FUCHI, Shunsuke , ABE, Yutaka
IPC分类号： A01M1/20 , A61P33/02 , C07D401/04 , C07D491/113 , A01P7/04 , A01N43/52 , A01N47/02 , A61K31/4439 , A61K31/444 , A61K31/695
摘要： Developed and provided are: an anticoccidial agent, and a using method thereof, where the anticoccidial agent has an excellent anticoccidial activity and can eliminate or minimize mass outbreak of coccidioses. Thus, provided are: an anticoccidial agent containing, as an active ingredient, a benzimidazole compound represented by General Formula (1), or a salt of the compound, and a method for using the agent. General Formula (1) is expressed as follows:
wherein R 1 typically represents haloalkyl; X typically represents oxygen; R typically represents alkyl; Y represents halogen; m denotes 0 or 1; Z represents alkyl or halogen; and n denotes 0, 1, or 2.-
公开(公告)号：EP3570866B1
公开(公告)日：2023-05-10
申请号：EP18702434.4
申请日：2018-01-19
发明人： WINQVIST, Ola , LINDH, Emma , WALLIN, Robert , GREGORY, Matt , MOSS, Steven
IPC分类号： A61K38/09 , A61K31/57 , A61K31/568 , A61K31/565 , A61P31/04 , A61P31/06 , A61P31/10 , A61P33/02 , A61P33/06
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