公开(公告)号：EP2816028B1

公开(公告)日：2019-11-27

申请号：EP12865775.6

申请日：2012-03-26

申请人： Korea Institute of Ocean Science and Technology

发明人： YIM, Joung Han ,  KIM, Il Chan ,  KIM, Dockyu ,  HAN, Se Jong ,  LEE, Hyoung Seok ,  BHATTARAI, Hari Datta ,  KIM, Tai Kyoung ,  KIM, Keun Sik

IPC分类号： C07C241/04 ,  C07C243/34 ,  C07C243/22 ,  C07B61/00 ,  C07C269/06 ,  C07C271/22 ,  C07C241/02

公开(公告)号：EP3461810A1

公开(公告)日：2019-04-03

申请号：EP18190199.2

申请日：2012-09-07

申请人： Intrexon Corporation

发明人： HORMANN, Robert E. ,  SHULMAN, Inna ,  RODEL, Eva ,  HILFIKER, Rolf ,  DEPAUL, Susan M.

IPC分类号： C07C243/18 ,  C12N5/10 ,  A01N37/40 ,  A61K31/66 ,  C07C243/38 ,  A61K47/10 ,  A61K47/22 ,  A61K47/24 ,  C07C241/02 ,  A61K31/166 ,  A61K47/12

摘要： The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N'-(2-ethyl-3-methoxybenzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N'-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject.

公开(公告)号：EP3442533A1

公开(公告)日：2019-02-20

申请号：EP17782038.8

申请日：2017-04-13

申请人： University Of Ottawa ,  University Of Maryland, Baltimore ,  University of Rochester

发明人： KEILLOR, Jeffrey W. ,  AKBAR, Abdullah ,  ECKERT, Richard L. ,  FISHER, Matthew ,  JOHNSON, Gail V.W.

IPC分类号： A61K31/495 ,  A61K31/496 ,  C07C271/22 ,  C07C311/30 ,  C07C241/02

公开(公告)号：EP2986590A4

公开(公告)日：2016-11-16

申请号：EP14785785

申请日：2014-04-18

申请人： ADESSO ADVANCED MATERIALS WUXI CO LTD

发明人： QIN BING ,  LI XIN ,  LIANG BO

IPC分类号： C07C217/84 ,  C07C201/12 ,  C07C213/02 ,  C07C241/02 ,  C07C241/04 ,  C07C243/28 ,  C07C243/38 ,  C08G59/50 ,  C08J5/24 ,  C08J11/16 ,  C08J11/26 ,  C08J11/28 ,  C08K7/06 ,  C08L63/00

CPC分类号： C07C243/38 ,  C07C201/12 ,  C07C213/02 ,  C07C217/84 ,  C07C241/02 ,  C07C243/28 ,  C08G59/1477 ,  C08G59/50 ,  C08J5/24 ,  C08J11/16 ,  C08J11/26 ,  C08K7/06 ,  Y02W30/705 ,  Y02W30/706

摘要： The present invention provides, among others, compounds of Formula (I) or a salt thereof, methods for making these compounds, degradable polymers and reinforced composites made therefrom, and methods for degrading and/or recycling the degradable polymers and reinforced composites.

公开(公告)号：EP2687515A1

公开(公告)日：2014-01-22

申请号：EP12758005.8

申请日：2012-03-15

申请人： Shionogi & Co., Ltd.

发明人： UENAKA, Masaaki ,  YONEZAWA, Shuji ,  IIDA, Akira ,  TAKAKI, Mutsumi ,  OGAWA, Tomoyuki ,  GODA, Satoshi ,  HIROSE, Yoshikatsu ,  FUKUDA, Tomohiro

IPC分类号： C07D231/20 ,  C07C241/02 ,  C07C243/16

CPC分类号： C07D231/20 ,  C07C243/16 ,  C07D413/06 ,  C07C241/02

摘要： Disclosed is a process for producing a pyrazole carboxylic acid derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor.
A compound represented by the Formula (XI):

is useful as a significant intermediate of an 11βHSD-1 inhibitor,
wherein R 1 and R 2 are each independently hydrogen or substituted or unsubstituted alkyl, R 3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl and R 4 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl.

摘要翻译： 本发明公开了一种制备可用作11βHSD-1抑制剂的重要中间体的吡唑羧酸衍生物的方法。 由式（XI）表示的化合物可用作11βHSD-1抑制剂的重要中间体，其中R 1和R 2各自独立地为氢或取代或未取代的烷基，R 3为取代或未取代的烷基，取代或未取代的链烯基，取代 取代或未取代的环烷基，取代或未取代的环烯基，取代或未取代的芳基，取代或未取代的杂芳基或取代或未取代的杂环基，并且R4为取代或未取代的烷基，取代或未取代的烯基，取代或未取代的炔基， 取代或未取代的环烯基，取代或未取代的芳基，取代或未取代的杂芳基或取代或未取代的杂环基。

公开(公告)号：EP2054465B1

公开(公告)日：2012-07-11

申请号：EP07789289.1

申请日：2007-08-22

申请人： ISIS INNOVATION LIMITED

发明人： MOLONEY, Mark ,  GRIFFITHS, Jon-Paul

IPC分类号： C08J7/12 ,  B05D5/10 ,  C03C17/28 ,  C09C1/00 ,  D06M13/00 ,  D06M13/03 ,  D06M13/11 ,  D06M13/288 ,  D06M13/338 ,  D06M13/322 ,  D21H25/02 ,  C07C241/02 ,  C07C245/14 ,  C07C243/18 ,  C07C249/16

CPC分类号： C08J7/12 ,  C01P2004/61 ,  C01P2004/64 ,  C03C17/28 ,  C07C245/12 ,  C07C245/20 ,  C07F9/3882 ,  C09C3/08 ,  C09C3/10 ,  D06M13/03 ,  D06M13/11 ,  D06M13/288 ,  D06M13/338

摘要： A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (I): whose substituent groups are defined herein, provided that when R is aryl or heteroaryl, said aryl or heteroaryl may be substituted by one, two, three, four or five groups, which groups are independently selected from various groups including -LB-WB; and (b) either: (i) when WA or WB comprises an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, thereby yielding said substrate having an adhesive surface; or (ii) when WA or WB comprises a group which is a precursor of an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, and (c) converting said group which is a precursor into an adhesive functional group thereby yielding said substrate having an adhesive surface. The invention further relates to carbene precursor compounds for use in the process, substrates produced by the process and to processes for preparing certain precursor compounds.

公开(公告)号：EP2282990B1

公开(公告)日：2011-10-12

申请号：EP09753880.5

申请日：2009-05-26

申请人： Grindeks, a joint stock company

发明人： ZICANE, Daina ,  TURKS, Maris

IPC分类号： C07C241/02 ,  C07C243/40

CPC分类号： C07C241/02 ,  C07C243/40

摘要： The invention provides an improved, efficient method for preparing 3- (2,2,2- trimethylhydrazinium) propionate dihydrate from 3- (2,2, 2-trimethylhydrazinium) propionate methylsulphate.

公开(公告)号：EP2282989A1

公开(公告)日：2011-02-16

申请号：EP09753876.3

申请日：2009-05-26

申请人： Grindeks, a joint stock company

发明人： ZICANE, Daina ,  TURKS, Maris

IPC分类号： C07C241/02 ,  C07C243/14

CPC分类号： C07C241/02 ,  C07C243/14

摘要： The invention provides an improved, efficient method for preparing3-(2,2- dimethylhydrazino)methylpropionate.

公开(公告)号：EP2128126A1

公开(公告)日：2009-12-02

申请号：EP08156903.0

申请日：2008-05-26

申请人： Grindeks, a joint stock company

发明人： Zicane, Daina ,  Turks, Maris

IPC分类号： C07C241/02 ,  C07C243/40

CPC分类号： C07C241/02 ,  C07C243/40

摘要： The invention provides an improved, efficient method for preparing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate from 3-(2,2,2-trimethylhydrazinium)propionate methylsulfate.

摘要翻译： 本发明提供从3-（2,2,2-三甲基肼）丙酸甲酯硫酸盐制备3-（2,2,2-三甲基肼）丙酸酯二水合物的改进的有效方法。

公开(公告)号：EP2069290A1

公开(公告)日：2009-06-17

申请号：EP06793164.2

申请日：2006-09-04

申请人： Silva, Jorge

发明人： Silva, Jorge

IPC分类号： C07C241/02 ,  C07C243/40

CPC分类号： C07C1/26 ,  C07C17/10 ,  C07C2529/40 ,  C07C9/00 ,  C07C19/075

摘要： A method for producing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate by saponification of salts of 3-(2,2,2-trimethylhydrazinium)propionate esters with subsequent purification step using saturation with carbon dioxide or sulphur dioxide in alcoholic solution.