公开(公告)号：EP1632476B1

公开(公告)日：2013-01-02

申请号：EP04745313.9

申请日：2004-05-19

申请人： SEIKAGAKU CORPORATION

发明人： SUZUKI, Kiyoshi, Keyakidaidanchi 2-510 ,  IIDA, Masami ,  KANEDA, Yuji ,  KUNII, Naoko ,  SAWA, Miwa

IPC分类号： C07C215/44 ,  C07C213/08 ,  C07C249/02 ,  C07C251/04 ,  C07C277/08 ,  C07C279/16 ,  A61K31/133 ,  A61K31/155 ,  A61P3/06 ,  A61P3/10

CPC分类号： C07C215/44

公开(公告)号：EP1270549A4

公开(公告)日：2003-07-02

申请号：EP01912321

申请日：2001-03-13

申请人： JAPAN SCIENCE & TECH CORP

发明人： KOBAYASHI SHU

IPC分类号： C07C227/10 ,  C07C213/08 ,  C07C215/08 ,  C07C227/12 ,  C07C229/18 ,  C07C229/24 ,  C07C251/04 ,  C07C251/08 ,  C07D211/86 ,  C07D215/48 ,  C07D221/18 ,  C07D491/04 ,  C07D491/048 ,  C08F8/30 ,  C08F246/00 ,  C07C227/04 ,  C07C229/36 ,  C08F8/00 ,  C08F212/00

CPC分类号： C07D491/04 ,  C07B2200/11 ,  C07C251/08 ,  C07D211/86 ,  C07D215/48 ,  C07D221/18 ,  C08F8/30 ,  C08F246/00

摘要： An α-iminoester derivative capable of being stably present under ordinary conditions; and a method of synthesizing various α-aminoester derivatives from the α-iminoester derivative in high yield. The derivative is a polymer-immobilized α-iminoester represented by the following general formula (1) (wherein R1 represents an alkyl chain having 1 or more carbon atoms and R2 represents hydrogen, halogeno, or optionally substituted alkyl, aryl, or alkoxy).

公开(公告)号：EP0781763B1

公开(公告)日：2002-09-18

申请号：EP96120925.1

申请日：1996-12-27

申请人： MITSUI CHEMICALS, INC.

发明人： Karasawa, Minato ,  Abe, Takeya ,  Shimizu, Takuji ,  Iwaki, Takeshi

IPC分类号： C07C233/35 ,  C07C251/04 ,  C08G59/44

CPC分类号： C08G59/44 ,  C07C233/35 ,  C07C233/36 ,  C07C251/02 ,  C07C251/08 ,  C08G18/12 ,  C08G59/4042 ,  C08L63/00 ,  C08G18/3256 ,  C08L77/00

公开(公告)号：EP2065364B1

公开(公告)日：2012-08-01

申请号：EP08170027.0

申请日：2008-11-26

申请人： Air Products and Chemicals, Inc.

发明人： Lei, Xinjian ,  Spence, Daniel P. ,  Cheng, Hansong

IPC分类号： C07C251/04 ,  C07C251/08 ,  C23C16/00 ,  C23C16/18 ,  C23C16/40

CPC分类号： C23C16/18 ,  C07F3/003 ,  C23C16/403 ,  C23C16/404 ,  C23C16/405 ,  C23C16/406

公开(公告)号：EP1100774B1

公开(公告)日：2004-01-21

申请号：EP99937293.1

申请日：1999-07-23

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： WOLFE, John, P. ,  AHMAN, Jens ,  SADIGHI, Joseph, P. ,  SINGER, Robert, A. ,  BUCHWALD, Stephen, L.

IPC分类号： C07C249/02 ,  C07C251/04

CPC分类号： C07C227/06 ,  C07C209/10 ,  C07C209/18 ,  C07C249/02 ,  C07C211/45 ,  C07C229/52 ,  C07C251/24

摘要： The present invention provides a process for the preparation of a wide range of primary arylamines. The arylamines are prepared in two efficient, straightforward transformations: 1) an activated aryl group and an imine group are combined, in the presence of a transition metal catalyst, under conditions wherein the transition metal catalyst catalyzes the formation of a carbon-nitrogen bond between the activated carbon of the arene and the imine nitrogen; and 2) the resulting N-aryl imine is transformed, via any of a number of standard protocols, to the primary arylamine. The process of the invention may also be exploited in the preparation of vinylamines.

公开(公告)号：EP1100774A1

公开(公告)日：2001-05-23

申请号：EP99937293.1

申请日：1999-07-23

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： WOLFE, John, P. ,  AHMAN, Jens ,  SADIGHI, Joseph, P. ,  SINGER, Robert, A. ,  BUCHWALD, Stephen, L.

IPC分类号： C07C249/02 ,  C07C251/04

CPC分类号： C07C227/06 ,  C07C209/10 ,  C07C209/18 ,  C07C249/02 ,  C07C211/45 ,  C07C229/52 ,  C07C251/24

摘要： The present invention provides a process for the preparation of a wide range of primary arylamines. The arylamines are prepared in two efficient, straightforward transformations: 1) an activated aryl group and an imine group are combined, in the presence of a transition metal catalyst, under conditions wherein the transition metal catalyst catalyzes the formation of a carbon-nitrogen bond between the activated carbon of the arene and the imine nitrogen; and 2) the resulting N-aryl imine is transformed, via any of a number of standard protocols, to the primary arylamine. The process of the invention may also be exploited in the preparation of vinylamines.

公开(公告)号：EP0605726A1

公开(公告)日：1994-07-13

申请号：EP93902545.8

申请日：1993-01-28

申请人： MITSUBISHI PETROCHEMICAL CO., LTD. ,  DAICEL CHEMICAL INDUSTRIES, LTD.

发明人： HASEBE, Hirokazu ,  HAMATANI, Takeshi ,  HAYASHIZAKI, Keiichi, Tsukuba Research Centre ,  USUI, Yoshihiro, Tsukuba Research Centre ,  YASUMOTO, Chiharu, Tsukuba Research Centre ,  GO, Atsushi, Tsukuba Research Centre ,  HIKIDO, Mitsuru, Tsukuba Research Centre ,  TAMURA, Kumiko, Tsukuba Research Centre ,  JIKIHARA, Kazuo, Tsukuba Research Centre

IPC分类号： C07D265/06 ,  C07D319/06 ,  C07C251/04 ,  A01N43/86

CPC分类号： A01N43/86 ,  C07C251/04 ,  C07D265/06 ,  C07D265/10 ,  C07D319/06

摘要： A 1,3-oxazin-4-one derivative, represented by general formula (I), which is useful as a herbicide because it has a wide herbicidal spectrum and a potent herbicidal activity and is highly safe for useful crops, wherein R¹ represents lower alkyl, lower alkenyl, lower alkynyl, optionally substituted aryl or optionally substituted aralkyl; R² represents hydrogen or lower alkyl; R³ represents lower alkyl, optionally substituted aryl or optionally substituted aralkyl; and R⁴ and R⁵ represent each independently lower alkyl, or R⁴ and R⁵ are combined with each other to represent, together with the carbon atom to which they are bonded, a 3- to 8-membered carbocyclic group which may have a lower alkyl branch.

摘要翻译： 由通式（I）表示的1,3-恶嗪-4-酮衍生物，其可用作除草剂，因为它具有宽的除草谱和强的除草活性，对有用的作物是高度安全的，其中R 1 表示低级烷基，低级烯基，低级炔基，任选取代的芳基或任选取代的芳烷基; R 2表示氢或低级烷基; R 3表示低级烷基，任选取代的芳基或任选取代的芳烷基; R 4和R 5各自独立地表示低级烷基，或者R 4和R 5彼此结合，与它们所键合的碳原子一起表示3-8 可能具有低级烷基支链的碳环基团。

公开(公告)号：EP0252003A2

公开(公告)日：1988-01-07

申请号：EP87810347.2

申请日：1987-06-18

申请人： CIBA-GEIGY AG

发明人： Ravichandran, Ramanathan ,  Snead, Thomas E.

IPC分类号： C07C251/04 ,  C08K5/32

CPC分类号： C08K5/32

摘要： Die Verbindungen der Formel I,
worin R¹ und R² unabhängig voneinander C₁-C₃₆-Alkyl, C₅-C₁₂-Cyclo­alkyl, C₇-C₉-Aralkyl oder durch C₁-C₃₆-Alkyl substituiertes C₇-C₉-­Aralkyl bedeuten und R³ und R⁴ unabhängig voneinander Wasserstoff, ein Alkalimetall, C₁-C₃₆-Alkyl, Phenyl oder durch C₁-C₁₂-Alkyl substituiertes Phenyl sind, eignen sich zum Stabilisieren von organischem Material gegen thermischen, oxidativen und/oder akti­nischen Abbau.

摘要翻译： 式I的化合物，其中R 1和R 2彼此独立地C1-C36烷基，C5-C12环烷基，C7-C9芳烷基，或C1-C36烷基取代的C 7 -C 9芳烷基，R和R 是<4>独立地是氢，碱金属，C1-C36烷基，苯基或由C 1 -C 12烷基取代的苯基，是适合于稳定针对热，氧化和/或光化降解的有机材料。

公开(公告)号：EP0136702A2

公开(公告)日：1985-04-10

申请号：EP84111800.3

申请日：1984-10-03

申请人： BASF Aktiengesellschaft

发明人： Jahn, Dieter, Dr. ,  Becker, Rainer, Dr. ,  Keil, Michael, Dr. ,  Schirmer, Ulrich, Dr. ,  Richarz, Winfried, Dr. ,  Wuerzer, Bruno, Dr. Dipl.-Landwirt ,  Meyer, Norbert, Dr.

IPC分类号： C07C251/04 ,  C07D309/06 ,  C07D213/52 ,  C07D335/02 ,  C07D307/14 ,  C07D261/18 ,  C07D493/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  A01N35/10

CPC分类号： C07D213/53 ,  A01N35/10 ,  A01N37/10 ,  A01N37/38 ,  A01N39/02 ,  A01N41/04 ,  A01N43/08 ,  A01N43/16 ,  A01N43/18 ,  A01N43/40 ,  A01N43/80 ,  A01N43/90 ,  A01N53/00 ,  A01N55/00 ,  A01N57/12 ,  C07D261/18 ,  C07D307/14 ,  C07D309/06 ,  C07D309/10 ,  C07D335/02 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D493/04 ,  C07F7/1856 ,  C07F9/177 ,  C07F9/582 ,  C07F9/65515

摘要： Die Erfindung betrifft Cyclohexenol-Derivate der Formel
in der R 1 , R 2 , R 3 , X und A die in der Beschreibung genannten Bedeutungen haben, Verfahren zur Herstellung dieser Verbindungen sowie ihre Verwendung zur Bekämpfung unerwünschten Pflanzenwuchses.

摘要翻译： 本发明涉及下式的环己烯醇衍生物，其中R 1，R 2，R 3，X和A具有说明书中给出的含义，涉及制备这些化合物的方法及其用于防治不希望的植物生长的用途。

公开(公告)号：EP3102194A1

公开(公告)日：2016-12-14

申请号：EP15705866.0

申请日：2015-02-03

申请人： Quadriga Biosciences, Inc.

发明人： JANDELEIT, Bernd ,  FISCHER, Wolf-Nicolas ,  KOLLER, Kerry J.

IPC分类号： A61K31/197 ,  A61K31/41 ,  A61K31/662 ,  C07C271/46 ,  C07C309/66 ,  C07C229/42 ,  C07D257/04 ,  C07D237/30 ,  C07C239/20 ,  C07C251/04 ,  C07F9/30 ,  A61P35/00

CPC分类号： A61K31/197 ,  A61K31/41 ,  A61K31/662 ,  A61K47/542 ,  C07C229/08 ,  C07C229/42 ,  C07C237/30 ,  C07C239/18 ,  C07C239/20 ,  C07C271/46 ,  C07C309/69 ,  C07D257/04 ,  C07F9/3264 ,  C07F9/48 ,  C07F9/4816

摘要： &bgr;-Substituted γ-amino acids, &bgr;-substituted γ-amino acid derivatives, and &bgr;-substituted γ-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The &bgr;-substituted γ-amino acid derivatives and &bgr;-substituted γ-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates, capable of passing through the blood-brain barrier, and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the &bgr;-substituted γ-amino acid derivatives and &bgr;-substituted γ-amino acid analogs and (bio)isosteres and methods of using the compounds for treating tumors are also disclosed. The &bgr;-substituted γ-amino acid derivatives and &bgr;-substituted γ-amino acid analogs and (bio)isosteres exhibit an improved selectivity toward tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The &bgr;-substituted γ-amino acid derivatives and &bgr;-substituted γ-amino acid analogs and (bio)isosteres exhibit an increased efficacy on a variety of tumor types.