公开(公告)号：EP3235806A1

公开(公告)日：2017-10-25

申请号：EP17000930.2

申请日：2012-02-29

申请人： Microbial Chemistry Research Foundation

发明人： Shibasaki, Masakatsu ,  Yamatsugu, Kenzo

IPC分类号： C07C227/10 ,  C07C227/16 ,  C07C227/32 ,  C07C229/30 ,  C07C229/34 ,  C07C229/48 ,  C07C229/60 ,  C07C269/04 ,  C07C269/06 ,  C07C271/24 ,  C07B53/00 ,  C07B61/00

CPC分类号： C07C229/48 ,  C07B53/00 ,  C07C229/30 ,  C07C229/34 ,  C07C229/60 ,  C07C269/06 ,  C07C271/24 ,  C07C2601/16 ,  Y02P20/55

摘要： A compound represented by the following general formula (7), a method for producing it, and its use in the preparation of oseltamivir phosphate.

摘要翻译： 由下述通式（7）表示的化合物，其制备方法及其在制备磷酸奥司他韦中的用途。

公开(公告)号：EP2684866A4

公开(公告)日：2015-05-06

申请号：EP12755315

申请日：2012-02-29

申请人： MICROBIAL CHEM RES FOUND

发明人： SHIBASAKI MASAKATSU ,  YAMATSUGU KENZO

IPC分类号： C07C227/10 ,  C07B53/00 ,  C07B61/00 ,  C07C227/16 ,  C07C227/32 ,  C07C229/30 ,  C07C229/34 ,  C07C229/48 ,  C07C229/60 ,  C07C269/04 ,  C07C269/06 ,  C07C271/24

CPC分类号： C07C229/48 ,  C07B53/00 ,  C07C229/30 ,  C07C229/34 ,  C07C229/60 ,  C07C269/06 ,  C07C271/24 ,  C07C2601/16 ,  Y02P20/55

摘要： A compound represented by the following general formula (7), a method for producing it, and its use in the preparation of oseltamivir phosphate.

公开(公告)号：EP2657222A1

公开(公告)日：2013-10-30

申请号：EP11800668.3

申请日：2011-06-22

申请人： National University Corporation Nagoya University

发明人： ISHIHARA, Kazuaki ,  HATANO, Manabu ,  HORIBE, Takahiro

IPC分类号： C07C227/10 ,  C07C229/24 ,  C07C269/06 ,  C07C271/22 ,  C07D213/55 ,  C07D307/54 ,  C07D333/24 ,  C07B53/00 ,  C07B61/00

CPC分类号： C07C209/60 ,  C07C227/10 ,  C07C269/06 ,  C07D213/55 ,  C07D307/54 ,  C07D333/24 ,  C07C229/24 ,  C07C271/22

摘要： An optically active β-aminocarbonyl compound is obtained by a Mannich reaction between an aldimine in which nitrogen is protected and a malonic acid diester, in the presence of optically active BINOL and dialkyl magnesium (in which two alkyl groups are the same or different) in an amount 1 to 2 molar times the amount of the BINOL.

摘要翻译： 在光学活性BINOL和二烷基镁（其中两个烷基相同或不同）的存在下，通过在其中保护氮的醛亚胺与丙二酸二酯之间的曼尼希反应获得光学活性的2-氨基羰基化合物 量为BINOL量的1-2摩尔倍。

公开(公告)号：EP2576499A2

公开(公告)日：2013-04-10

申请号：EP11728021.4

申请日：2011-05-31

申请人： Kemira OYJ

发明人： AKSELA, Reijo ,  RISSANEN, Jussi

IPC分类号： C07C227/10 ,  C07C229/24 ,  C07C227/06 ,  C07C227/16

CPC分类号： C07C227/10 ,  C07C227/06 ,  C07C227/16 ,  C07C229/24

摘要： The present invention relates to a process for the preparation of a mixture of aspartic acid diethoxy succinate and an amino acid derivative of the general formula (I) wherein n is 1-10, m is 0 or 1, and R is hydrogen or an alkali metal or alkaline earth metal ion, comprising reacting maleate with diethanol amine under alkaline conditions in the presence of a lanthanoid catalyst to form aspartic acid diethoxy succinate followed by adding aspartic acid which reacts with unreacted maleate to form imino disuccinic acid, i.e. an amino acid derivative of formula (I) wherein m is 0, or by adding a diamine derivative of the general formula (II) NH2(CH2)nNH2 wherein n is as defined above, which reacts with unreacted maleate to form an amino acid derivative of formula (I) wherein m is 1 and n is as defined above.

公开(公告)号：EP2550250A2

公开(公告)日：2013-01-30

申请号：EP11714076.4

申请日：2011-03-25

申请人： Sun Chemical B.V.

发明人： DAVIDSON, Robert Stephen ,  HERLIHY, Shaun Lawrence

IPC分类号： C07C227/10 ,  C07C229/18 ,  C08F2/50 ,  C09D11/10

摘要： Compounds of formula (I): wherein Ar represents an, optionally substituted, aryl or heteroaryl group, R represents an, optionally substituted, aryl or heteroaryl group, an optionally substituted straight or branched chain C1.10-alkyl, R1 is H or methyl, X is an extender group, n is 0 or an integer between 1 and 12 inclusive, A is a polyol residue wherein the unsubstituted polyol from which the residue is derived has at least y OH groups, and y is an integer>1, can easily be prepared, and are useful as synergists in radiation curing.

摘要翻译： 式（I）化合物：其中Ar表示任选取代的芳基或杂芳基，R表示任选取代的芳基或杂芳基，任选取代的直链或支链C 1-10 - 烷基，R 1是H或甲基 X为延长基团，n为0或1〜12的整数，A为多元醇残基，其中，残基来源的未取代的多元醇至少具有y OH基，y为1以上的整数， 易于制备，并且可用作辐射固化中的增效剂。

公开(公告)号：EP1101763A3

公开(公告)日：2002-04-24

申请号：EP00308971.1

申请日：2000-10-12

申请人： Pfizer Products Inc.

发明人： Tom, Norma Jacqueline

IPC分类号： C07D401/00 ,  C07D401/04 ,  C07C227/10

CPC分类号： C07D401/04

摘要： Methods of preparing NHE-1 inhibitors are disclosed. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.

公开(公告)号：EP1179530A1

公开(公告)日：2002-02-13

申请号：EP01904517.8

申请日：2001-02-16

申请人： Kaneka Corporation

发明人： SUGAWARA, Masanobu ,  FUJII, Akio ,  OKURO, Kazumi ,  SAKA, Yasuhiro ,  NAGASHIMA, Nobuo ,  INOUE, Kenji ,  TAKEDA, Toshihiro ,  KINOSHITA, Koichi ,  MOROSHIMA, Tadashi ,  FUSE, Yoshihide ,  UEDA, Yasuyoshi

IPC分类号： C07D203/08 ,  C07D203/24 ,  C07C227/04 ,  C07C227/10 ,  C07C229/26 ,  C07C311/19 ,  C07B53/00

CPC分类号： C07D203/08 ,  C07B2200/07 ,  C07C227/10 ,  C07C227/32 ,  C07C227/42 ,  C07C229/30 ,  C07C303/36 ,  C07D203/20 ,  C07D203/24 ,  C07C311/19 ,  C07C229/26

摘要： An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent.
According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

摘要翻译： 光学活性氨基酸衍生物是通过N-保护光学活性3-卤代丙氨酸衍生物进行环化，或环化该衍生物进行N-保护而得到光学活性N-保护的氮丙啶-2-羧酸衍生物 在2-和/或4-位被硝基取代的苯磺酰基保护，然后用有机金属试剂处理该产物，或通过N-保护光学活性3-卤代丙氨酸衍生物，由此得到N-保护的氮丙啶 -2-羧酸，其在2-和/或4-位被硝基取代的苯磺酰基保护，然后用有机金属试剂处理该产物。 根据该方法，可以通过简单的方法从便宜的材料制备天然和非天然旋光氨基酸。

公开(公告)号：EP1072584A4

公开(公告)日：2001-04-25

申请号：EP99907918

申请日：1999-03-12

申请人： JAPAN SCIENCE & TECH CORP

发明人： KOBAYASHI SHU ,  AOKI YOJI

IPC分类号： C07B61/00 ,  C07C227/10 ,  C07C227/16 ,  C07C229/06 ,  C07C229/28 ,  C07C229/34 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07C251/24 ,  C07C327/22 ,  C07D213/55 ,  C07D213/74 ,  C08F8/30 ,  C07C217/58 ,  C07F7/18 ,  C08G85/00

CPC分类号： C08F8/30 ,  C07B2200/11 ,  C07C227/10 ,  C07C227/16 ,  C07C229/28 ,  C07C229/34 ,  C07C251/24 ,  C07C327/22 ,  C07C2601/14 ,  C07D213/55 ,  C07D213/74 ,  C40B40/00 ,  C40B50/14

摘要： An imine fixed to a resin characterized in that it is represented by the following formula: P-Q-N=CH-R wherein P represents a main chain of a polymer constituting the resin, Q represents a hydrocarbon side chain optionally substituted with a substituent which may be bonded via a heteroatom and R represents an optionally substituted hydrocarbon group or a heterocyclic group, and a β-aminocarbonyl compound fixed to a resin represented by formula (II) are provided. The β-aminocarbonyl compound fixed to a resin is a β-aminocarbonyl compound being handled in a solid form. An amine fixed to a resin which is a key compound for a solid state synthesis of this type and represented by the following formula: P-Q1-O-Q2-NH2, wherein Q1 and Q2 are each a hydrocarbon chain selected from among an arylene group, an alkylarylene group and an arylenealkylene group, is also provided, which allows the synthesis of β-aminocarbonyl compound by application of an iminoaldol reaction in a solid phase.

公开(公告)号：EP0705815B1

公开(公告)日：1998-01-14

申请号：EP95113358.6

申请日：1995-08-25

申请人： BAYER AG

发明人： Rauchschwalbe, Günter, Dr. ,  Beitzke, Bernhard, Dr. ,  Eymann, Wolfgang, Dr. ,  Fiege, Helmut, Dr.

IPC分类号： C07C227/10 ,  C07C229/30 ,  C07D215/56

CPC分类号： C07D215/56 ,  C07C227/10 ,  C07C229/34

公开(公告)号：EP2847177A1

公开(公告)日：2015-03-18

申请号：EP13724059.4

申请日：2013-05-01

申请人： Boehringer Ingelheim International GmbH

发明人： KAPADIA, Suresh, R. ,  REEVES, Jonathan, Timothy ,  ZENG, Xingzhong ,  ERIKSSON, Magnus Carl Arne

IPC分类号： C07D305/06 ,  C07C213/02 ,  C07C215/10 ,  C07C227/10 ,  C07C229/24

CPC分类号： C07D305/06 ,  C07C213/00 ,  C07C215/10 ,  C07C215/28 ,  C07C227/10 ,  C07C229/24 ,  C07C229/34

摘要： This invention relates to methods for making oxetan-3-ylmethanamines having the formula (I) wherein R1? and R2? are as defined herein. The methods of the invention provide the compounds of formula (I) in high yields and under conditions amenable for large-scale commercial production.

摘要翻译： 本发明涉及制备具有式（I）的氧杂环丁烷-3-基甲胺的方法， 和R2？ 如本文所定义。 本发明的方法以高产率和适于大规模商业生产的条件提供式（I）化合物。