公开(公告)号：EP0447727A1

公开(公告)日：1991-09-25

申请号：EP90400781.2

申请日：1990-03-21

申请人： MERRELL DOW PHARMACEUTICALS INC.

发明人： Hibert, Marcel ,  Petty, Margaret A. ,  Jones, C. Richard

IPC分类号： C07C311/35 ,  A61K31/18

CPC分类号： C07C311/35 ,  C07C2602/10

摘要： A compound of the formula

the enantiomeric forms thereof and pharmaceutically acceptable salts thereof wherein
R₁ and R₂ each represents hydrogen or methyl, and
R₃ is C₁₋₇ lower alkyl, for use as pharmaceutically active compound.

摘要翻译： 式其对映体形式的化合物及其药学上可接受的盐，其中R 1和R 2各自表示氢或甲基，R 3为C 1-7低级烷基，用作药物活性化合物。

公开(公告)号：EP1177169A1

公开(公告)日：2002-02-06

申请号：EP00922738.0

申请日：2000-04-25

申请人： SANOFI-SYNTHELABO

发明人： ALCOUFFE, Chantal ,  BELLEVERGUE, Patrice ,  DELLAC, Geneviève ,  LATHAM, Christopher ,  LASSALLE, Gilbert ,  MALLART, Sergio ,  MARTIN, Valérie ,  MASSON, Christine ,  MCCORT, Gary

IPC分类号： C07C257/18 ,  C07D213/40 ,  A61K31/17 ,  A61K31/18 ,  A61P7/00 ,  C07C275/26 ,  C07C275/24 ,  C07C311/27 ,  C07C311/13 ,  C07C311/04 ,  C07C279/16 ,  C07D213/34 ,  C07D215/22 ,  C07D215/08 ,  C07D277/26 ,  C07D277/24 ,  A61K31/44 ,  A61K31/425 ,  C07C311/35 ,  C07D213/79 ,  C07D277/28

CPC分类号： C07D213/40 ,  C07C311/07 ,  C07C311/09 ,  C07C311/13 ,  C07C311/27 ,  C07C311/35 ,  C07C317/28 ,  C07C323/44 ,  C07D213/34 ,  C07D213/79 ,  C07D215/08 ,  C07D215/227 ,  C07D277/24 ,  C07D277/26 ,  C07D277/28 ,  C07D295/26

摘要： The invention concerns compounds of general formula (I) wherein: R1 represents either a hydrogen atom, or an amino group, or a C1-C4 alkyl group, or a C1-C6 alkoxycarbonyl group, or a -OH group; R2 represents either a C1-C6 alkyl group, or a phenyl or benzyl group, or a -CH2Q group, wherein Q is a heterocyclic group; R3 and R5 represent independently of each other for example either a hydrogen atom, or a C1-C4 alkyl group, or a -COOH group; R4 represents either a hydrogen atom, or a C1-C4 alkyl group, or a -(CH2)p-COOR8 group; Z represents either a -CH- group, or a nitrogen atom. The invention also concerns the methods of preparation and therapeutic use of said compounds.

公开(公告)号：EP0553016B1

公开(公告)日：1997-05-07

申请号：EP93400111.6

申请日：1993-01-19

申请人： ADIR ET COMPAGNIE

发明人： Depreux, Patrick ,  Lesieur, Daniel ,  Abdellaoui, Habib ,  Guardiola, Béatrice ,  Adam, Gérard ,  Renard, Pierre ,  Pfeiffer, Bruno

IPC分类号： C07C311/35 ,  C07C237/20 ,  A61K31/18 ,  A61K31/165 ,  C07D295/08 ,  C07D209/52

CPC分类号： C07D295/096 ,  C07C311/35 ,  C07C2601/14 ,  C07D209/52 ,  C07D295/26

公开(公告)号：EP0451008B1

公开(公告)日：1995-06-28

申请号：EP91400770.3

申请日：1991-03-21

申请人： MERRELL DOW PHARMACEUTICALS INC.

发明人： Hibert, Marcel ,  Petty, Margaret A. ,  Jones, C. Richard

IPC分类号： C07C311/35 ,  A61K31/18

CPC分类号： C07C311/35 ,  C07C2602/10

公开(公告)号：EP2155662B1

公开(公告)日：2010-12-01

申请号：EP08805936.5

申请日：2008-06-04

申请人： Galderma Research & Development

发明人： BOITEAU, Jean-Guy ,  CLARY, Laurence ,  PASCAL, Jean-Claude ,  PARNET, Véronique

IPC分类号： C07C233/54 ,  C07C233/55 ,  C07C309/65 ,  C07C309/66 ,  C07C309/71 ,  C07C311/32 ,  C07C311/35 ,  C07C59/64 ,  C07C59/68 ,  C07C69/734 ,  A61P17/00 ,  A61Q19/08 ,  A61Q5/00 ,  A61Q19/00

CPC分类号： C07C309/66 ,  C07C59/68 ,  C07C69/017 ,  C07C69/734 ,  C07C233/54 ,  C07C233/55 ,  C07C309/65 ,  C07C309/71 ,  C07C311/32 ,  C07C311/35 ,  C07C2601/14

摘要： The invention relates to novel derivatives of 3-phenyl propanoic acid of the following general formula (I), to a method for preparing the same, and to the use thereof in pharmaceutical compositions used in human or veterinary medicine (in dermatology as well as in the field of cardio-vascular diseases, immune diseases and/or diseases related to lipid metabolism), or in cosmetic compositions.

摘要翻译： 本发明涉及下列通式（I）的3-苯基丙酸的新衍生物，其制备方法，及其在用于人或兽医药物的药物组合物中的用途（皮肤病学以及 心血管疾病领域，免疫疾病和/或与脂质代谢有关的疾病）或化妆品组合物中。

公开(公告)号：EP2155662A2

公开(公告)日：2010-02-24

申请号：EP08805936.5

申请日：2008-06-04

申请人： Galderma Research & Development

发明人： BOITEAU, Jean-Guy ,  CLARY, Laurence ,  PASCAL, Jean-Claude ,  PARNET, Véronique

IPC分类号： C07C233/54 ,  C07C233/55 ,  C07C309/65 ,  C07C309/66 ,  C07C309/71 ,  C07C311/32 ,  C07C311/35 ,  C07C59/64 ,  C07C59/68 ,  C07C69/734 ,  A61P17/00 ,  A61Q19/08 ,  A61Q5/00 ,  A61Q19/00

CPC分类号： C07C309/66 ,  C07C59/68 ,  C07C69/017 ,  C07C69/734 ,  C07C233/54 ,  C07C233/55 ,  C07C309/65 ,  C07C309/71 ,  C07C311/32 ,  C07C311/35 ,  C07C2601/14

摘要： The invention relates to novel derivatives of 3-phenyl propanoic acid of the following general formula (I), to a method for preparing the same, and to the use thereof in pharmaceutical compositions used in human or veterinary medicine (in dermatology as well as in the field of cardio-vascular diseases, immune diseases and/or diseases related to lipid metabolism), or in cosmetic compositions.

摘要翻译： 新的3-苯基丙酸化合物具有下述通式（I）：和配制成在人或兽医学给药的药物组合物（在皮肤科，因此，在心血管疾病，免疫疾病和/或脂质的领域代谢相关的 疾病），或者，可替代地，进化妆品组合物。

公开(公告)号：EP1226116A1

公开(公告)日：2002-07-31

申请号：EP00972875.9

申请日：2000-10-27

申请人： BASF AKTIENGESELLSCHAFT

发明人： HOLMAN, Nicholas, John ,  FRIEND, Christopher, Lyndon

IPC分类号： C07C303/40 ,  C07C311/35 ,  C07D209/14

CPC分类号： C07D209/14 ,  C07C303/40 ,  C07C311/35

摘要： The present invention relates to a process for preparing phenylhydrazines of formula (I) in which R represents CH2SO2NHCH3, CH2CH2SO2Ph, CH2CH2SO2NHMe or a group of structure (A), (B), (C), in which a diazonium salt of formula (II) in which X represents an anion derived from hydrochloric acid, sulphuric acid, acetic acid, phosphoric acid, tetrafluoroboric acid or hydrobromic acid is reduced by a dithionite salt. The resulting phenylhydrazines can be converted to the corresponding indole derivatives by the Fischer indole synthesis.

公开(公告)号：EP2238105A4

公开(公告)日：2012-02-22

申请号：EP09706694

申请日：2009-01-28

申请人： AMOREPACIFIC CORP

发明人： SHIN SONG SEOK ,  KIM JIN KWAN ,  KIM SUN-YOUNG ,  LEE KI-WHA ,  WOO BYOUNG YOUNG ,  MOH JOO-HYUN ,  JEONG YEON SU ,  LIM KYUNG MIN ,  CHOI JIN KYU ,  KOH HYUN-JU ,  PARK YOUNG-HO

IPC分类号： C07C311/45 ,  C07C311/08 ,  C07C311/13 ,  C07C311/35 ,  C07D295/145

CPC分类号： C07C311/08 ,  C07C2601/14 ,  C07D295/145

公开(公告)号：EP2238105A2

公开(公告)日：2010-10-13

申请号：EP09706694.8

申请日：2009-01-28

申请人： Amorepacific Corporation

发明人： SHIN, Song Seok ,  KIM, Jin Kwan ,  KIM, Sun-Young ,  LEE, Ki-Wha ,  WOO, Byoung young ,  MOH, Joo-Hyun ,  JEONG, Yeon Su ,  LIM, Kyung Min ,  CHOI, Jin Kyu ,  KOH, Hyun-Ju ,  PARK, Young-Ho

IPC分类号： C07C311/45 ,  C07C311/13 ,  C07C311/35

CPC分类号： C07C311/08 ,  C07C2601/14 ,  C07D295/145

摘要： This present disclosure relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present disclosure provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

公开(公告)号：EP0839799A1

公开(公告)日：1998-05-06

申请号：EP96913739.7

申请日：1996-05-14

申请人： KISSEI PHARMACEUTICAL CO., LTD.

发明人： SATOH, Fumiyasu ,  HARADA, Hiromu 8054, Oaza Nakagawa ,  KUSAMA, Hiroshi ,  IYOBE, Akira Medio-Hotaka A101 ,  KOIZUMI, Takashi Rezidensu-Chino F-202 ,  KAMATA, Koji Fureguransu-Merodi A101 ,  KATSUNO, Kenji ,  KOBAYASHI, Miho 2583, Oaza Minamihotaka

IPC分类号： C07C229/36 ,  C07C237/20 ,  C07C309/24 ,  C07C311/35 ,  C07C317/28 ,  A61K31/195 ,  A61K31/165 ,  A61K31/215

CPC分类号： C07D231/36 ,  C07B2200/07 ,  C07C229/34 ,  C07C229/36 ,  C07C237/20 ,  C07D237/20

摘要： The present invention relates to a 2-hydroxyphenyl alkylamine derivative represented by the general formula:
wherein R 1 , R 2 , R 3 and R 4 are the same or different: and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a hydroxy group, a mercapto group, a halogen atom, a nitro group, an amino group, an acylamino group, an acyl group or a hydroxy(lower alkyl) group; R 5 represents a hydrogen atom or a lower alkyl group; A represents a single bond, a lower alkylene group which may have a hydroxy group as a substituent or a lower alkenylene group; Y represents a single bond or a lower alkylene group; and Z represents a carboxyl group, a lower alkoxycarbonyl group, an aryloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl group etc. and a pharmaceutically acceptable salt thereof which have a Maillard reaction inhibiting activity.

摘要翻译： 本发明涉及由以下通式表示的2-羟基苯基烷基胺衍生物：其中R 1，R 2，R 3和R 4相同或不同，表示： 氢原子，低级烷基，低级烷氧基，羟基，巯基，卤素原子，硝基，氨基，酰氨基，酰基或羟基（低级烷基）基团; R 5表示氢原子或低级烷基; A表示单键，可以具有羟基作为取代基的低级亚烷基或低级亚烯基; Y表示单键或低级亚烷基; Z表示具有美拉德反应抑制活性的羧基，低级烷氧基羰基，芳氧基羰基，芳烷氧基羰基，氨基甲酰基等及其药学上可接受的盐。