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1.发明公开NOUVEAUX COMPOSÉS DI-SUBSTITUÉS DE LA DIAMINO-3,4-CYCLOBUTÈNE-3-DIONE-1,2 UTILES DANS LE TRAITEMENT DE PATHOLOGIES MÉDIÉES PAR DES CHIMIOKINES 有权NEW二取代3,4-二氨基-3-环丁烯-1,2-二酮化合物FOR USE IN疾病治疗趋化因子介导的
公开(公告)号：EP2771336A1
公开(公告)日：2014-09-03
申请号：EP12791824.1
申请日：2012-10-26
发明人： MUSICKI, Branislav , AUBERT, Jérôme , ROSSIO, Patricia , SCHUPPLI-NOLLET, Marlène , CLARY, Laurence , BOITEAU, Jean-Guy
IPC分类号： C07D407/06 , C07D409/06 , A61K31/341
CPC分类号： A61K31/4525 , A61K31/351 , A61K31/382 , C07D405/06 , C07D407/06 , C07D409/06
摘要： The present invention relates to novel disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds corresponding to the following general formula (I):, to the pharmaceutical compositions containing these compounds and also to the use of these compounds and of these compositions for the treatment of chemokine-mediated diseases.
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2.发明授权N-[2-HYDROXYCARBAMOYL-2-(PIPERAZINYL)ETHYL]BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS 有权N- [2-羟基氨基甲酰基-2-（哌嗪基）乙基]苯甲酰胺化合物，其制备以及它们作为TACE抑制剂
公开(公告)号：EP2477968B1
公开(公告)日：2013-10-23
申请号：EP10754506.3
申请日：2010-09-16
IPC分类号： C07D213/30 , C07D215/14 , C07D295/26 , A61K31/495 , A61P29/00
CPC分类号： C07D295/26 , C07D209/12 , C07D211/22 , C07D213/30 , C07D215/14 , C07D231/12 , C07D233/02 , C07D307/79 , C07D401/12 , C07D471/04
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3.发明公开N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL]BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS 有权N- [2-羟基氨基甲酰基-2-（哌嗪基）乙基]苯甲酰胺化合物，其制备以及它们作为TACE抑制剂
公开(公告)号：EP2477968A1
公开(公告)日：2012-07-25
申请号：EP10754506.3
申请日：2010-09-16
IPC分类号： C07D213/30 , C07D215/14 , C07D295/26 , A61K31/495 , A61P29/00
CPC分类号： C07D295/26 , C07D209/12 , C07D211/22 , C07D213/30 , C07D215/14 , C07D231/12 , C07D233/02 , C07D307/79 , C07D401/12 , C07D471/04
摘要： The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I), and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.
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4.发明公开BIPHENYLMETHYL-THIAZOLIDINEDIONES ET ANALOGUES ET LEUR UTILISATION COMME ACTIVATEUR PPAR-GAMMA 有权BIPHENYLMETHYLTHIAZOLIDINDIONE类似物和它们作为PPAR-γ激活剂
公开(公告)号：EP1458697A1
公开(公告)日：2004-09-22
申请号：EP02805790.9
申请日：2002-12-09
IPC分类号： C07D277/34 , C07D417/12 , C07C233/87 , C07C235/78 , C07C235/66 , A61K31/426 , A61K31/427 , A61K7/48 , A61P17/00
CPC分类号： A61K8/416 , A61K8/49 , A61K8/4913 , A61K8/4986 , A61K2800/70 , A61Q19/007 , A61Q19/06 , C07D277/34 , C07D417/12
摘要： The invention concerns bi-aromatic compounds of general formula (I), wherein: R1 is (a) or (b), R5 being hydroxy or alkoxy and R6 being alkyl, OR14 or SR14 which are PPAR-gamma receptors. They are useful in pharmaceutical compositions for use in human and veterinary medicine (in dermatology, as well as for cardiovascular diseases, immune diseases and/or diseases related to lipid metabolism), or in cosmetic compositions.
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5.发明公开NOUVEAUX COMPOSÉS DI-SUBSTITUÉS DE LA DIAMINO-3,4-CYCLOBUTÈNE-3-DIONE-1,2 UTILES DANS LE TRAITEMENT DE PATHOLOGIES MÉDIÉES PAR DES CHIMIOKINES 有权NEW二取代3,4-二氨基-3-环丁烯-1,2-二酮化合物，其用在治疗疾病CHEMOKINVERMITTELTER
公开(公告)号：EP2771329A1
公开(公告)日：2014-09-03
申请号：EP12791825.8
申请日：2012-10-26
发明人： MUSICKI, Branislav , AUBERT, Jerôme , BOITEAU, Jean-Guy , CLARY, Laurence , ROSSIO, Patricia , SCHUPPLI-NOLLET, Marlène
IPC分类号： C07D307/14 , C07D407/06 , C07D409/06 , C07D409/14 , A61K31/341 , A61K31/381 , A61K31/4025 , A61P17/06 , A61P11/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/06
CPC分类号： C07D409/14 , A61K31/341 , A61K31/381 , A61K31/4025 , C07D307/14 , C07D307/16 , C07D307/54 , C07D407/06 , C07D409/06
摘要： The present invention relates to novel disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds corresponding to the following general formula (I): , to the pharmaceutical compositions containing these compounds and also to the use of these compounds and of these compositions for the treatment of chemokine-mediated diseases.
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6.发明公开
公开(公告)号：EP2448931A1
公开(公告)日：2012-05-09
申请号：EP10745347.4
申请日：2010-06-28
发明人： CLARY, Laurence , CHAMBON, Sandrine , CHANTALAT, Laurent , MAUVAIS, Pascale , ROYE, Olivier , SCHUPPLI, Marlène
IPC分类号： C07D401/12 , C07D295/15 , A61K31/40 , A61K31/4453 , A61K31/4709 , A61K31/5375 , A61K31/5377 , A61P35/00 , A61P25/00 , A61P29/00
CPC分类号： C07D295/15 , C07D401/12
摘要： The present invention relates to novel benzenesulfonamide compounds having a structure of the following general formula (I), as well as to the method for synthesizing same, and to the use thereof in pharmaceutical compositions to be used in human or veterinary medicine, as well as to the use thereof in cosmetic compositions.
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7.发明授权COMPOUNDS THAT MODULATE PPARY TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS 有权PPAR受体调节性化合物及其USE IN的化妆品或药物组合物
公开(公告)号：EP1814871B1
公开(公告)日：2011-03-02
申请号：EP05817959.9
申请日：2005-11-17
IPC分类号： C07D333/38 , A61K31/381 , A61Q19/08 , A61P17/00
CPC分类号： C07D333/22 , C07D213/55 , C07D213/75 , C07D239/26 , C07D307/46 , C07D333/20
摘要： The invention relates to novel compounds corresponding to the general formula (I) below: and also to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or alternatively in cosmetic compositions.
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8.发明公开NOUVEAUX DÉRIVÉS D'ACIDE 3-PHENYL ACRYLIQUE ACTIVATEURS DES RÉCEPTEURS DE TYPE PPAR, LEUR MÉTHODE DE PRÉPARATION ET LEUR UTILISATION DANS DES COMPOSITIONS COSMÉTIQUES OU PHARMACEUTIQUES 审中-公开激活的3苯基丙烯酸新衍生物PPAR受体，PROCESS用于生产和它们在化妆品或药物组合物
公开(公告)号：EP2164827A2
公开(公告)日：2010-03-24
申请号：EP08805937.3
申请日：2008-06-04
IPC分类号： C07C309/65 , C07C309/66 , C07C309/67 , C07C311/08 , C07C311/13 , C07C65/28 , C07C233/07 , A61K8/36 , A61K8/42 , A61K8/46 , A61K31/192 , A61P17/00 , A61P19/10
CPC分类号： C07C309/65 , A61K8/365 , A61K8/42 , A61K8/466 , A61Q5/02 , A61Q19/10 , C07C59/68 , C07C217/76 , C07C233/25 , C07C235/56 , C07C309/66 , C07C309/67 , C07C311/08 , C07C311/13
摘要： The invention relates to novel derivatives of 3-phenyl acrylic acid of the following general formula (I), to a method for preparing the same, and to the use thereof in pharmaceutical compositions used in human or veterinary medicine (in dermatology as well as in the field of cardio-vascular diseases, immune diseases and/or diseases related to lipid metabolism), or in cosmetic compositions.
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9.发明授权BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMMA TYPE RECEPTORS AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS 有权双芳香CONNECTIONS该PPAR-γ受体活化及其应用在化妆品或药物组合物
公开(公告)号：EP1575911B1
公开(公告)日：2010-01-13
申请号：EP03782482.8
申请日：2003-11-18
IPC分类号： C07C275/40 , C07C275/28 , A61K8/44 , A61K8/49 , A61Q19/00 , A61K31/17 , A61K31/198 , A61K31/223
CPC分类号： C07D207/27 , A61K8/44 , A61K8/49 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C229/36 , C07C233/47 , C07C233/54 , C07C233/55 , C07C233/65 , C07C233/81 , C07C233/87 , C07C235/52 , C07C235/60 , C07C235/74 , C07C235/84 , C07C237/20 , C07C237/40 , C07C243/28 , C07C271/22 , C07C275/42 , C07C323/60 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D207/335 , C07D211/16 , C07D211/34 , C07D211/62 , C07D213/38 , C07D213/40 , C07D263/32 , C07D265/30 , C07D271/06 , C07D271/10 , C07D295/088 , C07D295/185 , C07D295/205 , C07D307/81 , C07D333/20
摘要： The invention relates to novel biaromatic compounds which correspond to the general formula (I), and also to a process for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the field of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or alternatively in cosmetic compositions.
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10.发明公开NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE RECEPTORS OF PPAR TYPE AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS 有权新型的双芳族PPAR受体活化化合物和它们在化妆品或药物组合物
公开(公告)号：EP1781274A1
公开(公告)日：2007-05-09
申请号：EP05782445.0
申请日：2005-08-12
IPC分类号： A61K31/137 , C07C233/87 , A61P17/00
CPC分类号： C07C233/47 , C07C233/87 , C07C235/52
摘要： The invention relates to novel biaromatic compounds which correspond to the following general formula (I) and to their method of preparation and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology and in the field of cardiovascular diseases, of immune diseases and/or of diseases related to the metabolism of lipids) or alternatively in cosmetic compositions.
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