公开(公告)号：EP4436959A1

公开(公告)日：2024-10-02

申请号：EP22897852.4

申请日：2022-11-23

申请人： Allorion Therapeutics Inc.

发明人： CHENG, Dai ,  DING, Qiang ,  ZHANG, Tao

IPC分类号： C07D239/48 ,  C07D405/12 ,  A61K31/505 ,  A61P35/00

CPC分类号： C07D239/48 ,  A61P35/00 ,  Y02P20/55 ,  C07D239/47 ,  C07D405/12 ,  C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D239/42 ,  C07D401/04

公开(公告)号：EP4382514A1

公开(公告)日：2024-06-12

申请号：EP22853399.8

申请日：2022-08-01

申请人： Korea Research Institute of Chemical Technology ,  Industry-Academic Cooperation Foundation, Yonsei University

发明人： LEE, Kwangho ,  DUGGIRALA, Krishna Babu ,  CHOI, Gil Don ,  CHAE, Chong Hak ,  JUNG, Myoung Eun ,  LEE, Yujin ,  CHO, Byoung Chul

IPC分类号： C07D239/48 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/54 ,  A61K45/06 ,  A61P35/00 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D417/12

CPC分类号： A61K31/505 ,  A61K31/5377 ,  A61K31/54 ,  A61K45/06 ,  A61P35/00 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/12

摘要： The present invention relates to a pyrimidine derivative, a method for preparing same, and a pharmaceutical composition for preventing or treating cancer comprising same as an active ingredient. The pyrimidine derivative of the present invention exhibits a high inhibitory ability against EGFR mutation and HER2 mutation, and thus can be effectively used in treatment of cancer in which EGFR mutation and HER2 mutation have occurred.

公开(公告)号：EP4380924A1

公开(公告)日：2024-06-12

申请号：EP22852071.4

申请日：2022-07-29

申请人： DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

发明人： ZHENG, Jun-Cheng ,  JIANG, Jianan ,  GUO, Qinghai ,  CHANG, Shih-Ying ,  ZENG, Qingbei ,  TSUI, Honchung ,  YANG, Zhenfan ,  ZHANG, Xiaolin

IPC分类号： C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  A61P35/02 ,  A61P37/02

CPC分类号： A61P37/02 ,  A61P35/02 ,  C07D403/12 ,  C07C57/15 ,  C07B2200/1320130101

公开(公告)号：EP3712144B1

公开(公告)日：2024-02-14

申请号：EP18873029.5

申请日：2018-10-31

发明人： ZHAO, Yanping ,  WANG, Hongjun ,  LI, Gong ,  LI, Xiang ,  JIANG, Yuanyuan ,  LIU, Kai ,  WANG, Yeming ,  ZHOU, Liying ,  LIU, Yanan ,  SHAO, Ning ,  XIAO, Fengping

IPC分类号： C07D401/12 ,  C07D401/06 ,  C07D239/48 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D487/04 ,  C07D498/18 ,  C07F9/53 ,  A61P13/10 ,  A61K31/506

公开(公告)号：EP4274829A1

公开(公告)日：2023-11-15

申请号：EP22736479.1

申请日：2022-01-07

申请人： Ontario Institute for Cancer Research (OICR) ,  The Governing Council of the University of Toronto ,  Sinai Health System

发明人： AL-AWAR, Rima ,  ATTISANO, Liliana ,  ISAAC, Methvin ,  LIU, Yong ,  SMIL, David ,  UEHLING, David ,  WRANA, Jeff

IPC分类号： C07D409/14 ,  A61K31/506 ,  A61K31/551 ,  A61K31/5383 ,  A61P35/00 ,  C07D239/48 ,  C07D241/36 ,  C07D409/12 ,  C07D451/02 ,  C07D471/10 ,  C07D487/04 ,  C07D498/04

公开(公告)号：EP4242203A1

公开(公告)日：2023-09-13

申请号：EP21889635.5

申请日：2021-11-05

申请人： Pelemed Co., Ltd.

发明人： KIM, Yong Chul ,  PARK, Sung Gyoo ,  SEO, Jiwon ,  KIM, Woo Chan ,  JUNG, Jae Hoon ,  CHO, Yuri ,  KIM, Yoon Jun

IPC分类号： C07D401/12 ,  A61K31/5377 ,  A61K31/506 ,  A61P31/20 ,  A61P31/14 ,  A61P31/18 ,  C07D239/48

摘要： The present invention relates to a series of novel phenylaminopyridine derivatives and a use thereof for inhibiting capsid assembly and for preventing or treating virus infectious diseases thereby.

公开(公告)号：EP4010324B1

公开(公告)日：2023-09-06

申请号：EP20751840.8

申请日：2020-07-31

发明人： RUANO PLAZA, Sra. Gema

IPC分类号： C07D239/48 ,  A61P3/10 ,  A61P3/00 ,  A61K31/505

公开(公告)号：EP4132913A1

公开(公告)日：2023-02-15

申请号：EP21717022.4

申请日：2021-04-01

申请人： Syngenta Crop Protection AG

发明人： WAILES, Jeffrey, Steven ,  TATE, Joseph, Andrew

IPC分类号： C07D239/48 ,  C07D403/12 ,  C07D413/12 ,  A01N43/54

公开(公告)号：EP4112605A1

公开(公告)日：2023-01-04

申请号：EP22745149.9

申请日：2022-01-21

申请人： Anhui Medical University

发明人： LIU, Xinhua ,  CHEN, Xing ,  SHI, Jingbo ,  LIU, Mingming ,  YAN, Yaoyao ,  ZHANG, Zhaoyan ,  ZHANG, Famin

IPC分类号： C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D403/12 ,  A61P29/00 ,  A61P37/00 ,  A61P19/02 ,  A61P1/18 ,  A61P13/12 ,  A61P11/00 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/505 ,  A61K31/541

摘要： The present disclosure discloses a pyrimidine-2,4-diamine compound and a preparation method and application thereof, relating to the technical field of medicinal chemistry. The pyrimidine-2,4-diamine compound of the present disclosure can be used in the research of biological or pharmacological phenomena and cathepsin C-involved signal pathway transduction and the evaluation of novel cathepsin C inhibitors. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-cathepsin C activity in vitro and in vivo and proved to have strong inhibitory activity on cathepsin C. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-NSP activity in vivo and proved to have strong inhibitory activity on NSP. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-inflammatory activity in vivo and proved to have an effective therapeutic effect on inflammatory disease models. Meanwhile, the pyrimidine-2,4-diamine compound shows low toxicity and exhibits good application prospect.

公开(公告)号：EP4066838A1

公开(公告)日：2022-10-05

申请号：EP20892653.5

申请日：2020-11-26

申请人： Shenzhen Chipscreen Biosciences Co., Ltd.

发明人： WANG, Shigang ,  SHAN, Song ,  YU, Jingdi ,  LIU, Xia ,  ZHAO, Chuantong ,  ZHANG, Yu ,  DENG, Xingyu ,  HUANG, Ning ,  WANG, Xianghui ,  PAN, Desi

IPC分类号： A61K31/506 ,  A61P29/00 ,  C07D239/48

摘要： Disclosed are a composition containing an aromatic heterocyclic compound in an amorphous form, and a preparation method therefore and a use thereof. Specifically, disclosed is a composition containing a compound of Formula (1) and a carrier, wherein the compound of formula (1) is in an amorphous form. The composition shows valuable properties in terms of in vivo absorption and bioavailability, and has the advantages of rapid absorption and high bioavailability, etc.