专利检索 ipc:C07D499/48 第 1 页

1.

发明公开
Isopenicillin N derivatives, their preparation and use and intermediates therefor 失效
标题翻译：异青霉素N-衍生物，它们的制造和使用以及它们的中间体。

公开(公告)号：EP0174129A1

公开(公告)日：1986-03-12

申请号：EP85305911.1

申请日：1985-08-20

申请人： NATIONAL RESEARCH DEVELOPMENT CORPORATION

发明人： Baldwin, Jack Edward

IPC分类号： C07D499/48 , C12P37/00 , A61K31/43 , C07K5/06

CPC分类号： C12N9/93 , A61K38/00 , C07C59/315 , C07C271/22 , C07D499/00 , C07K5/0215 , C12P37/00 , C12R1/465 , C12R1/75 , C12R1/82 , Y02A50/473 , Y02A50/481

摘要： A compound of formula I or a physiologically acceptable salt thereof

wherein X represents sulphur or methylene, R, represents hydrogen, amino or an acylated or carbamylated amino group, R 2 represents hydrogen or an alkyl group and R 3 represents an alkoxy group; preparation thereof by subjecting a tripeptide of formula III,
to the action of the enzyme isopenicillin N synthethase, and the tripeptide of formula III.

2.

发明公开
MOLECULES HYBRIDES QA OU Q EST UNE AMINOQUINOLEINE ET A EST UN RESIDU ANTIBIOTIQUE, LEUR SYNTHESE ET LEURS UTILISATIONS EN TANT QU'AGENT ANTIBACTERIEN 审中-公开
标题翻译： HYBRID QA分子，其中Q和A是氨基喹啉抗生素残留它们的合成及它们作为抗菌剂

公开(公告)号：EP1771456A2

公开(公告)日：2007-04-11

申请号：EP05793347.5

申请日：2005-07-26

申请人： Palumed SA , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Etablissement Public

发明人： SANCHEZ, Muriel , MEUNIER, Bernard

IPC分类号： C07D499/76 , C07D499/48 , C07D499/54 , C07D499/64 , C07D501/00 , C07D501/34 , A61P31/04 , C07D215/56 , C07D401/12 , C07D401/14 , A61K31/4709 , C07K5/00

CPC分类号： C07D215/56 , C07D401/12 , C07D413/12 , C07D499/00 , C07D501/00 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K9/008

摘要： The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q-(Y1)p-(U)p'-(Y2)p''-A; wherein Q represents an aminoquinoline, (Y1)p-(U)p'-(Y2)p'' is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.