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21 条记录 (耗时 0.016 秒)

    Cephem compounds and their production
    2.
    发明公开
    Cephem compounds and their production 失效
    头孢烯化合物及其生产

    公开(公告)号：EP0160745A3

    公开(公告)日：1986-11-05

    申请号：EP84115169

    申请日：1984-12-11

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Harada, Setsuo ,  Nozaki, Yukimasa ,  Ono, Hideo

    IPC分类号： C07D501/28 ,  C12P35/06 ,  C12P35/08

    CPC分类号： C12P35/06 ,  C12P35/08 ,  C12R1/64

    摘要： A compound of the formula:
    wherein R 1 stands for hydrogen or formylamino, R 2 is a residue of amino acid or peptide selected from the group consisting of serine and alanine or hydrogen, R 3 stands for -NH-C (=NH) -NH 2 or -CH 2 NH 2 , or its salt, which can be produced by cultivating a microorganism belonging to the genus Xanthomonas, is useful as a therapeutic agent against infectious disease caused by bacteria.

    摘要翻译： 具有下式的化合物：其中R 1代表氢或甲酰氨基，R 2代表选自丝氨酸和丙氨酸或氢的氨基酸或肽的残基，R 3代表-NH-C（= NH）-NH 2或 - 可以通过培养属于黄单胞菌属的微生物生产的CH2NH2或其盐可用作抗细菌引起的传染病的治疗剂。

    Cephalosporin compounds
    3.
    发明公开
    Cephalosporin compounds 失效
    Cephalosporinderivate。

    公开(公告)号：EP0089216A2

    公开(公告)日：1983-09-21

    申请号：EP83301392.3

    申请日：1983-03-14

    申请人： GLAXO GROUP LIMITED

    发明人： Miller, Thomas ,  Robinson, John Malcolm

    IPC分类号： C07D501/28 ,  C07D501/18 ,  C07D501/34 ,  A61K31/545

    CPC分类号： C07D501/18 ,  C07D501/26

    摘要： Novel cephalosporin compounds are described which are characterised by having a phenoxyacetoxymethyl group at the 3-position. The new compounds are particularly useful intermediates in the synthesis of cephalosporin antibiotics having a 3-methyl group carrying the residue of a nucleophile.

    摘要翻译： 描述了新的头孢菌素化合物，其特征在于在3-位具有苯氧基乙酰氧基甲基。 新化合物在具有携带亲核体残基的3-甲基的头孢菌素抗生素的合成中是特别有用的中间体。

    7-Acyl-3-(substituted carbamoyloxy) cephem compounds, use thereof and process for their preparation
    4.
    发明公开
    7-Acyl-3-(substituted carbamoyloxy) cephem compounds, use thereof and process for their preparation 失效
    7-ACYL-3-（取代的碳酰氧基）CEPHEM化合物，其制备方法及其制备方法

    公开(公告)号：EP0484966A3

    公开(公告)日：1993-03-10

    申请号：EP91119065.0

    申请日：1991-11-08

    申请人： Eisai Co., Ltd.

    发明人： Negi, Shigeto ,  Yamanaka, Motosuke ,  Katsu, Kanemasa ,  Sugiyama, Isao ,  Komatu, Yuuki ,  Kamata, Atsushi ,  Tsuruoka, Akihiko ,  Machida, Yoshimasa

    IPC分类号： C07D501/34 ,  C07D501/18 ,  C07D501/28 ,  A61K31/545

    CPC分类号： C07D501/00

    摘要： A 7-acyl-3-substituted carbamoyloxy cephem compound represented by the following formula (1):

    wherein A means a -CH= or -N= group; R¹ denotes a hydroxyl, lower alkoxyl, fluorine-substituted lower alkoxyl or protected hydroxyl group; R² and R³ are the same or different and individually represent a lower alkyl, hydroxyl-substituted lower alkyl, a carbamoyl-substituted lower alkyl group or cyano-substituted lower alkyl group, R² is a hydrogen atom and R³ is a lower alkoxyl or alkyl group optionally substituted by one or more halogen atoms, or the group

    means a 4-6 membered heterocyclic group, which contains one nitrogen atom, or a morpholino group, said heterocyclic group or morpholino group being optionally substituted by one or more lower alkyl, hydroxyl and/or hydroxyl-substituted lower alkyl groups; and R⁴ denotes a carboxyl or protected carboxyl group; or a pharmaceutically acceptable salt thereof; and a process for the preparation thereof; use thereof as well as an antibacterial composition containing the above cephem compound.