公开(公告)号：EP4330266A1

公开(公告)日：2024-03-06

申请号：EP22726628.5

申请日：2022-04-29

申请人： Avignon Universite ,  Centre National de la Recherche Scientifique ,  UNIVERSITE DE MONTPELLIER ,  Ecole Nationale Supérieure de Chimie de Montpellier

发明人： DURAND, Grégory ,  WEHBIE, Moheddine

IPC分类号： C07H15/06 ,  C07H15/18 ,  C11D1/00 ,  C07C19/08 ,  C07C23/02 ,  C07C25/13 ,  C07C291/04 ,  C07C309/04

公开(公告)号：EP4281466A1

公开(公告)日：2023-11-29

申请号：EP22702200.1

申请日：2022-01-20

申请人： Tfchem

发明人： DELIENCOURT GODEFROY, Géraldine ,  LEGOEDEC, Jocelyne ,  LOPES, Lénaïg

IPC分类号： C07H7/02 ,  C07H15/18 ,  A61Q19/00 ,  A61Q19/08 ,  A61K31/7028

公开(公告)号：EP4223315A3

公开(公告)日：2023-08-23

申请号：EP22204389.5

申请日：2015-05-01

申请人： Ionis Pharmaceuticals, Inc.

发明人： MIGAWA,, Michael, T. ,  YU,, Jinghua ,  WAN,, W., Brad ,  PATEL,, Satyen, P. ,  VASQUEZ,, Guillermo ,  KINBERGER,, Garth, A. ,  PRAKASH,, Thazha, P. ,  SETH,, Punit, P. ,  SWAYZE,, Eric, E.

IPC分类号： C07H1/00 ,  C07H15/18 ,  A61K47/54

摘要： Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

公开(公告)号：EP4186915A1

公开(公告)日：2023-05-31

申请号：EP21841411.8

申请日：2021-07-15

申请人： Sichuan University ,  Academy of Military Medical Sciences ,  Chengdu Aupone Pharmaceutical Co., Ltd.

发明人： QIN, Yong ,  ZHONG, Wu ,  XUE, Fei ,  LIU, Xiaoyu ,  WANG, Yu ,  ZHOU, Xiaohan ,  LIU, Bo ,  WANG, Ke ,  YANG, Likai ,  ZHOU, Ruijie ,  XIAO, Yaxin ,  XUE, Fanglin ,  ZHANG, Minjie ,  SONG, Hao ,  ZHENG, Zhibing ,  LI, Song

IPC分类号： C07H15/18 ,  C07H15/10 ,  C07H15/04 ,  C07H1/00 ,  C07F7/10

摘要： Disclosed is a method for preparing a C-nucleoside compound represented by Formula (III) or salt thereof. The present method has a high reaction yield, is simple to operate, uses a single metal reagent, has stable reaction temperature conditions, does not require frequent changes to the reaction system during the operation process, is suitable for scale-up synthesis, is suitable for large-scale production of Remdesivir, and has low costs.

公开(公告)号：EP4103576A1

公开(公告)日：2022-12-21

申请号：EP21705454.3

申请日：2021-02-10

申请人： Glycoscience, S.L.

发明人： SUTTON, Peter William

IPC分类号： C07H15/18 ,  C07H15/04 ,  C07H15/20 ,  C07H17/00 ,  C07H1/00 ,  A01N43/16 ,  A61K8/60 ,  A01P17/00

公开(公告)号：EP4036099A1

公开(公告)日：2022-08-03

申请号：EP21209687.9

申请日：2015-10-29

申请人： Gilead Sciences, Inc.

发明人： AXT, Steven Donald ,  BADALOV, Pavel Robertovich ,  BRAK, Katrien ,  CAMPAGNA, Silvio ,  CHTCHEMELININE, Andrei ,  DOERFFLER, Edward ,  FRICK, Morin Mae ,  GAO, Detian ,  HEUMANN, Lars V. ,  HOANG, Brittanie ,  LEW, Willard ,  MILBURN, Robert Ronald ,  NEVILLE, Sean Timothy ,  ROSS, Bruce ,  RUEDEN, Erick ,  SCOTT, Robert William ,  SIEGEL, Dustin ,  STEVENS, Andrew C. ,  TADEUS, Clarissa ,  VIERA, Tiago ,  WALTMAN, Andrew W. ,  WANG, Xianghong ,  WHITCOMB, Mark Charles ,  WOLFE, Lydia ,  YU, Chia-Yun

IPC分类号： C07H1/02 ,  C07H1/00 ,  C07H11/00 ,  C07H15/18 ,  A61P31/12 ,  A61P31/00 ,  A61P43/00 ,  A61K31/675 ,  A61K31/685 ,  A61K31/706 ,  A61K31/7056 ,  C07D487/04 ,  C07D519/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  A61P31/14

摘要： Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
A method preparing a compound of Formula (XI-a 2 ) is disclosed:

公开(公告)号：EP3969460A1

公开(公告)日：2022-03-23

申请号：EP20808981.3

申请日：2020-05-15

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  Holoclara, Inc.

发明人： STOLTZ, Brian, M. ,  REEVES, Corey, M. ,  MARTINEZ, Eduardo, J. ,  BAILEY, Simon

IPC分类号： C07H15/10 ,  C07H15/04 ,  C07H15/18 ,  C07H15/26 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/351 ,  A61K31/4025 ,  A61K31/4433 ,  A61K31/453 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  A61P37/08

公开(公告)号：EP3707147A1

公开(公告)日：2020-09-16

申请号：EP18808499.0

申请日：2018-11-05

申请人： Università degli Studi di Milano - Bicocca

发明人： PERI, Francesco ,  MINOTTI, Alberto

IPC分类号： C07H1/00 ,  C07H1/02 ,  C07H13/06 ,  C07H23/00 ,  C07H15/18 ,  A61K31/7024 ,  A61K31/7028 ,  A61P35/00 ,  A61P37/00 ,  A61P31/00

公开(公告)号：EP3563682A1

公开(公告)日：2019-11-06

申请号：EP19169996.6

申请日：2012-08-08

申请人： California Institute of Technology ,  Boyce Thompson Institute For Plant Research

发明人： STERNBERG, Paul Warren ,  CHOE, Andrea ,  SCHROEDER, Frank Clemens ,  VON REUSS, Stephan Heinrich

IPC分类号： A01N43/16 ,  A01N63/00 ,  A01P5/00 ,  A01P21/00 ,  A61K31/454 ,  A01N43/38 ,  C07H15/04 ,  C07H15/08 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  A01N43/90 ,  C07H19/16 ,  A01N37/36 ,  A01N63/02 ,  A61K31/7028 ,  C07D309/10

摘要： The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.

公开(公告)号：EP3502119A3

公开(公告)日：2019-10-02

申请号：EP18196575.7

申请日：2015-05-08

申请人： Immunexcite, Inc.

发明人： SIEDLECKI, James Michael ,  REZNIK, Gabriel Oscar ,  KANE, John James ,  MIAO, Hua ,  KLUGE, Arthur F. ,  RUBIN-BEJERANO, Ifat

IPC分类号： C07H3/06 ,  C07H5/04 ,  C07H13/04 ,  C07H15/04 ,  C07H15/18 ,  C07H15/203 ,  C07H15/26 ,  C07H19/044 ,  C07H19/048 ,  A61K31/716

摘要： This invention relates to modifications of β-1,6-D-glucans, e.g., structures according to Formula (I), and the ability of these compositions to modulate an immune response.