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    SYNTHETIC MIXTURE OF OLIGOSACCHARIDES FOR T TREATING A MICROBIOTA OF A MAMMAL
    10.
    发明公开
    SYNTHETIC MIXTURE OF OLIGOSACCHARIDES FOR T TREATING A MICROBIOTA OF A MAMMAL 审中-公开
    SYNTHETISCHE MISCHUNG澳大利亚西伯利亚ZUR BEHANDLUNG EINERBIOZÖNOSEEINESSÄUGETIERS

    公开(公告)号：EP2999358A1

    公开(公告)日：2016-03-30

    申请号：EP14800640.6

    申请日：2014-05-22

    申请人： Glycom A/S

    发明人： DEKANY, Gyula

    IPC分类号： A23L33/00 ,  C07H3/06 ,  C07H5/04 ,  C07H15/04

    CPC分类号： A61K31/702 ,  A23L33/10 ,  A23V2002/00 ,  C07H3/06 ,  C07H5/04 ,  C07H15/04 ,  A23V2200/32 ,  A23V2250/28

    摘要： The present application discloses a synthetic mixture of oligosaccharides for treating a microbiota of a mammal, preferably a human, to reduce or eliminate the activity and/or the proportion of a microbe in the microbiota that is associated with the development or maintenance of a disease or an unhealthy condition of the mammal, e.g. wherein the microbiota is a gut microbiota, or wherein the disease is a cardiovascular disease, gastrointestinal tract disorder, obesity, diabetes, autism, or atherosclerosis, or wherein the microbiota is a skin microbiota, such as where the unhealthy condition is a chronic wound caused by diabetes, wherein the mixture comprises at least 6 oligosaccharides selected from the following: one or more GlcNAc-containing oligosaccharides, and/or one or more fucosylated oligosaccharides, and/or one or more sialylated oligosaccharides, and/or one or more mannose containing oligosaccharides, and/or one or more GalNAc-containing oligosaccharides, and/or one or more sulfated oligosaccharides.

    摘要翻译： 本申请公开了用于治疗哺乳动物（优选人）的微生物群的寡糖的合成混合物，以减少或消除与发展或维持疾病相关的微生物群中的微生物的活性和/或比例，或 哺乳动物的不健康状况，例如 其中所述微生物群是肠道微生物群，或其中所述疾病是心血管疾病，胃肠道疾病，肥胖症，糖尿病，孤独症或动脉粥样硬化，或其中所述微生物群是皮肤微生物群，例如不健康状况是慢性伤口引起的 其中所述混合物包含至少6种选自以下的寡糖：一种或多种含GlcNAc的寡糖，和/或一种或多种岩藻糖基化寡糖，和/或一种或多种唾液酸化寡糖，和/或一种或多种含有甘露糖的甘露糖 寡糖和/或一种或多种含GalNAc的寡糖，和/或一种或多种硫酸化寡糖。