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    METHOD OF ALPHA-SELECTIVE GLYCOSYLATION
    1.
    发明授权
    METHOD OF ALPHA-SELECTIVE GLYCOSYLATION 有权
    方法选择性α糖基化

    公开(公告)号：EP1626053B1

    公开(公告)日：2011-07-06

    申请号：EP04733984.1

    申请日：2004-05-19

    申请人： Japan Science and Technology Agency

    发明人： ANDO, Hiromune ,  IMAMURA, Akihiro ,  KISO, Makoto ,  ISHIDA, Hideharu

    IPC分类号： C07H9/00 ,  C07H1/00

    CPC分类号： C07H1/00 ,  C07H9/00 ,  Y02P20/55

    摘要： A method of α-selective glycosylation comprising forming a cyclic protective group having a silyl acetal structure over hydroxyl groups at the 4- and 6-positions in a hexose or higher saccharide structure, which is a monosaccharide or the reducing end of an oligosaccharide (i.e., disaccharide or higher) or a sugar chain, and effecting a glycosylation reaction between this saccharide structure and an alcoholic hydroxyl or thiol group to thereby give glycosides of saccharide structure containing an α-glycoside at a high ratio. According to the above constitution, highly selective α-glycosylation in a saccharide structure can be carried out by an easy and convenient method.

    METHOD OF ALPHA-SELECTIVE GLYCOSYLATION
    2.
    发明公开
    METHOD OF ALPHA-SELECTIVE GLYCOSYLATION 有权
    VERFAHREN ZUR ALPHA-SELEKTIVEN GLYCOSYLIERUNG

    公开(公告)号：EP1626053A2

    公开(公告)日：2006-02-15

    申请号：EP04733984.1

    申请日：2004-05-19

    申请人： Japan Science and Technology Agency

    发明人： ANDO, Hiromune ,  IMAMURA, Akihiro ,  KISO, Makoto ,  ISHIDA, Hideharu

    IPC分类号： C07H9/00

    CPC分类号： C07H1/00 ,  C07H9/00 ,  Y02P20/55

    摘要： An α-selective glycosylation process of a glycosylation reaction between a sugar structure of hexose or an aldose having a chain with six or more carbon atoms in the molecule, which is a monosaccharide or a reducing end of an oligosaccharide with two or more monosaccharide residues connected by glycosidic or a sugar chain and alcoholic hydroxyl group or thiol group, to obtain a sugar structure glycoside containing α-glycoside at a high ratio, under the ring-shaped formation of a protective group in a silyl acetal structure over hydroxyl groups at positions 4 and 6 in the sugar structure.
    By the process, highly selective α-glycosylation of sugar structure can be progressed in a simple and efficient manner.

    摘要翻译： 在分子中具有六个或更多个碳原子的链的己糖或醛糖的糖结构之间的糖基化反应的±选择性糖基化方法，其是连接有两个或更多个单糖残基的寡糖的单糖或还原末端 通过糖苷或糖链和醇羟基或硫醇基，以在高度比例的羟基上在甲硅烷基缩醛结构中形成保护基的环状形成高糖比例的糖结构糖苷 和6在糖结构。 通过该过程，糖结构的高度选择性的 - - 糖基化可以以简单有效的方式进行。

    Saccharide mercaptals
    8.
    发明公开
    Saccharide mercaptals 失效
    糖类硫醇

    公开(公告)号：EP0516300A3

    公开(公告)日：1992-12-16

    申请号：EP92304185.9

    申请日：1992-05-08

    申请人： IMPERIAL CHEMICAL INDUSTRIES PLC

    发明人： Johnson, Trevor ,  Rennie, Robert Alan Campbell

    IPC分类号： C07H15/14 ,  C07H9/00

    CPC分类号： C07H15/14 ,  C07H9/00

    摘要： Process for the preparation of a mercaptal of an oligosaccharide which process comprises the step of reacting the oligosaccharide with a thiol in the presence of an aqueous halocarboxylic or halosulphonic acid.

    摘要翻译： 制备低聚糖巯基的方法，该方法包括在卤代羧酸或卤代磺酸水溶液存在下使低聚糖与硫醇反应的步骤。

    METHOD FOR PREPARING 3-O-BENZYL-1,2-O-ISOPROPYLIDENE- -L-FURAN IDOSE
    9.
    发明公开
    METHOD FOR PREPARING 3-O-BENZYL-1,2-O-ISOPROPYLIDENE- -L-FURAN IDOSE 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON 3-O-苄基-1,2-O-异丙基-L-呋喃糖

    公开(公告)号：EP2818476A4

    公开(公告)日：2015-09-23

    申请号：EP13751650

    申请日：2013-02-22

    申请人： ZHEJIANG HISUN PHARM CO LTD

    发明人： GUO YANGHUI ,  WEI HEGENG ,  ZHOU JUNHUI ,  WU YINGQIU ,  ZHANG YUE ,  BAI HUA ,  HE LIANG ,  DING YILI

    IPC分类号： C07H15/18 ,  C07D493/00 ,  C07D493/02 ,  C07D493/04 ,  C07H9/00 ,  C07H9/02 ,  C07H9/04 ,  C07H15/00 ,  C07H15/26

    CPC分类号： C07H1/00 ,  C07H15/18 ,  C07H19/01

    摘要： Provided is a method for preparing 3-O-benzyl-1,2-O-isopropylidene-±-L-idofuranose, which comprises: (1) protecting hydroxyl of 3-O-benzyl-1,2-O-isopropylidene-±-D-glucofuranose (III) by benzoyl and methylsulfonyl to obtain 6-O-benzoyl-3-O-benzyl-1,2-O-isopropylidene-5-O-methylsulfonyl-±-D-glucofuranose (V); (2) subjecting compound (V) to a cyclization reaction under an alkaline condition to obtain 5,6-epoxy-3-O-benzyl-1,2-O-isopropylidene-±-L-idofuranose (VI); and (3) subjecting compound (VI) to a ring-opening reaction to obtain 3-O-benzyl-1,2-O-isopropylidene-±-L-idofuranose.

    摘要翻译： 提供了一种制备3-O-苄基-1,2-邻 - 异亚丙基-L-异呋喃糖的方法，其包括：（1）保护3-O-苄基-1,2-O-异亚丙基 - D-吡喃葡萄糖（III），得到6-O-苯甲酰基-3-O-苄基-1,2-O-异亚丙基-5-O-甲基磺酰基-D-葡萄糖呋喃糖（V）; （2）在碱性条件下使化合物（V）进行环化反应，得到5,6-环氧-3-O-苄基-1,2-邻异丙叉基-L-异呋喃糖（VI）; 和（3）使化合物（VI）进行开环反应，得到3-O-苄基-1,2-O-异亚丙基-DL-阿托呋喃糖。