公开(公告)号：EP4397673A1

公开(公告)日：2024-07-10

申请号：EP22864578.4

申请日：2022-08-30

申请人： FUJIFILM Corporation

发明人： SHIROKANE, Kenji ,  YOSHIMITSU, Yuji ,  HAMADA, Naoka

IPC分类号： C07K2/00 ,  A61K47/54 ,  A61K47/64 ,  A61K49/00 ,  C07K1/04 ,  C07K1/107 ,  C07K16/00 ,  C09K11/06 ,  G01N33/533

CPC分类号： A61K47/54 ,  A61K47/64 ,  A61K49/00 ,  C07K1/04 ,  C07K1/107 ,  C07K2/00 ,  C07K16/00 ,  C09K11/06 ,  G01N33/533

摘要： There are provided a compound having at least two phosphor moieties and a structure represented by General Formula (I), and a labeled biological substance.

In the formula, X1 to X3 represent -O-, -S-, >NR1, or >CR2R3. R1 to R3 represent a hydrogen atom or a substituent. La and Lb represents a single bond or a divalent linking group. n is an integer of 2 or more.
However, at least one among R1 to R3, which are contained in a structure parenthesized in ( )n, La, and Lb includes -(L-O)gRE, where -(L-O)gRE in each of these groups is not bonded to at least any one of a phosphor or a biological substance.
L represents an alkylene group, RE represents a hydrogen atom or an alkyl group, and g is 1 to 24.
* represents a bonding site.

公开(公告)号：EP4378947A1

公开(公告)日：2024-06-05

申请号：EP22849383.9

申请日：2022-07-22

申请人： Providence Health & Services - Oregon ,  Shimadzu Corporation

发明人： KOGUCHI, Yoshinobu ,  IWAMOTO, Noriko ,  SHIMADA, Takashi

IPC分类号： C07K2/00

CPC分类号： C07K2/00

摘要： A method of identifying an unknown spliced peptide derived from a known parent peptide contained in a biological sample, the method comprising: (1) a first step involving performing mass spectrometry on the sample to obtain mass spectrometry data regarding a peptide contained in the sample; (2) a second step involving searching a primary library, which is a database of known amino acid sequences, for an amino acid sequence that matches the mass spectrometry data, to identify a parent peptide contained in the sample; (3) a third step involving creating a secondary library including a candidate group of spliced peptides obtainable from the identified parent peptide; and (4) a fourth step involving searching the secondary library for an amino acid sequence that matches the mass spectrometry data, to identify a spliced peptide contained in the sample.

公开(公告)号：EP4365184A1

公开(公告)日：2024-05-08

申请号：EP22833331.6

申请日：2022-07-01

申请人： Peptistar Inc. ,  Sekisui Medical Co., Ltd.

发明人： NEMOTO, Yoshitaka ,  ABE, Hitoshi ,  MORI, Toshihiro

IPC分类号： C07K1/04 ,  C07K1/16 ,  C07K2/00 ,  B01D15/32 ,  B01D15/40 ,  B01D15/42 ,  G01N30/02 ,  G01N30/26 ,  G01N30/88

CPC分类号： Y02P20/54 ,  B01D15/32 ,  B01D15/40 ,  B01D15/42 ,  C07K1/04 ,  G01N30/02 ,  G01N30/88 ,  C07K2/00 ,  C07K1/16 ,  G01N30/26

摘要： To provide a means capable of simultaneously and accurately analyzing a component derived from a carrier for liquid phase peptide synthesis with, for example, a target peptide.
A method for simultaneously analyzing a carrier for liquid phase peptide synthesis, a component derived from the carrier for liquid phase peptide synthesis, an amino acid to which the carrier for liquid phase peptide synthesis is bound, and a peptide compound to which the carrier for liquid phase peptide synthesis is bound, with a target peptide or final target peptide, the analysis method using high-performance liquid chromatography or supercritical fluid chromatography using an alcohol as an eluent.

公开(公告)号：EP4296672A1

公开(公告)日：2023-12-27

申请号：EP23180231.5

申请日：2023-06-20

申请人： SYSMEX CORPORATION

发明人： SATO, Haruya ,  NAITOH, Katsuki ,  KATAOKA, Yukiko ,  NISHIKAWA, Yochi ,  OKANO, Daiki

IPC分类号： G01N33/533 ,  C07K2/00 ,  C07K16/46 ,  G01N33/535 ,  G01N33/58

摘要： Disclosed is a labeled polypeptide that includes a glutamine residue having a side chain represented by formula (I) below:

(wherein, (C) represents an α-carbon of the glutamine residue, X represents a straight chain alkylene group, Y represents a polyethylene glycol chain, Z represents a label, L represents a spacer or an atomic bond, and the polyethylene glycol chain has a molecular weight of 1100 or larger).

公开(公告)号：EP3488007B1

公开(公告)日：2023-12-20

申请号：EP17831956.2

申请日：2017-07-21

发明人： QU, Guang ,  WRIGHT, John Fraser ,  OH, Younghoon ,  WANG, Yuhuan ,  ZHANG, Haibo ,  DUNCAN, Laura

IPC分类号： C12N15/861 ,  C12N7/00 ,  A61K48/00 ,  C07K2/00 ,  C12N15/64

公开(公告)号：EP4242220A1

公开(公告)日：2023-09-13

申请号：EP21889053.1

申请日：2021-10-22

申请人： Kagoshima University

发明人： ITO Yuji ,  NAKAYAMA Hiroshi ,  RAFIQUE Md Abdur

IPC分类号： C07K1/22 ,  A61K45/00 ,  A61K47/62 ,  A61P43/00 ,  C07C49/16 ,  C07K1/10 ,  C07K2/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C12P21/00

摘要： A crosslinking agent for a protein or a peptide is represented by the following formula (I). In the formula, A is a hydrogen atom, a C1 to 6 alkyl group optionally substituted with a phenyl group or a halogen atom, or a phenyl group.

公开(公告)号：EP4034545A1

公开(公告)日：2022-08-03

申请号：EP20775801.2

申请日：2020-09-24

申请人： Universiteit Gent

发明人： DE SPIEGELEER, Bart ,  VERBEKE, Frederick ,  BRACKE, Nathalie ,  WYNENDAELE, Evelien

IPC分类号： C07K1/12 ,  C07K2/00 ,  G01N33/00 ,  C07K14/765

公开(公告)号：EP3950703A1

公开(公告)日：2022-02-09

申请号：EP20783507.5

申请日：2020-03-26

申请人： NOF Corporation ,  Tokyo Institute of Technology

发明人： YOSHIOKA, Hiroki ,  OSAKAMA, Kazuki ,  HAMURA, Mika ,  INABA, Takanori ,  NISHIYAMA, Nobuhiro ,  MATSUI, Makoto ,  TAKEMOTO, Hiroyasu ,  NOMOTO, Takahiro ,  SUN, Xiaohang

IPC分类号： C07K2/00 ,  C07K19/00 ,  A61K47/64 ,  A61K47/65 ,  A61K38/18 ,  A61K38/23 ,  A61K38/27

摘要： A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A):

wherein each symbol is as defined in the present specification, is provided by the present invention.

公开(公告)号：EP3574922B1

公开(公告)日：2021-09-15

申请号：EP19185831.5

申请日：2014-04-09

发明人： PETERSEN, John S. ,  SHANAHAN, James

IPC分类号： A61K47/54 ,  A61K47/58 ,  A61K47/65 ,  A61K47/50 ,  A61K31/485 ,  A61K31/336 ,  A61K31/77 ,  C07D407/08 ,  C08F22/22 ,  C07K2/00 ,  A61K38/06 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  A61P5/50

公开(公告)号：EP3864024A1

公开(公告)日：2021-08-18

申请号：EP19871333.1

申请日：2019-10-10

申请人： University of Washington

发明人： TSAO, Caroline ,  LUOZHONG, Sijin ,  CORRIGAN, Trevor ,  JIANG, Shaoyi ,  LIU, Erik ,  MCMULLEN, Patrick

IPC分类号： C07K2/00 ,  C07K4/00